Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight
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Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. / Tyrrell, Jessica; Huikari, Ville; Christie, Jennifer T; Cavadino, Alana; Bakker, Rachel; Brion, Marie-Jo A; Geller, Frank; Paternoster, Lavinia; Myhre, Ronny; Potter, Catherine; Johnson, Paul C D; Ebrahim, Shah; Feenstra, Bjarke; Hartikainen, Anna-Liisa; Hattersley, Andrew T; Hofman, Albert; Kaakinen, Marika; Lowe, Lynn P; Magnus, Per; McConnachie, Alex; Melbye, Mads; Ng, Jane W Y; Nohr, Ellen A; Power, Chris; Ring, Susan M; Sebert, Sylvain P; Sengpiel, Verena; Taal, H Rob; Watt, Graham C M; Sattar, Naveed; Relton, Caroline L; Jacobsson, Bo; Frayling, Timothy M; Sørensen, Thorkild I A; Murray, Jeffrey C; Lawlor, Debbie A; Pennell, Craig E; Jaddoe, Vincent W V; Hypponen, Elina; Lowe, William L; Jarvelin, Marjo-Riitta; Davey Smith, George; Freathy, Rachel M; Early Growth Genetics (EGG) Consortium.
In: Human Molecular Genetics, Vol. 21, No. 24, 2012, p. 5344-58.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight
AU - Tyrrell, Jessica
AU - Huikari, Ville
AU - Christie, Jennifer T
AU - Cavadino, Alana
AU - Bakker, Rachel
AU - Brion, Marie-Jo A
AU - Geller, Frank
AU - Paternoster, Lavinia
AU - Myhre, Ronny
AU - Potter, Catherine
AU - Johnson, Paul C D
AU - Ebrahim, Shah
AU - Feenstra, Bjarke
AU - Hartikainen, Anna-Liisa
AU - Hattersley, Andrew T
AU - Hofman, Albert
AU - Kaakinen, Marika
AU - Lowe, Lynn P
AU - Magnus, Per
AU - McConnachie, Alex
AU - Melbye, Mads
AU - Ng, Jane W Y
AU - Nohr, Ellen A
AU - Power, Chris
AU - Ring, Susan M
AU - Sebert, Sylvain P
AU - Sengpiel, Verena
AU - Taal, H Rob
AU - Watt, Graham C M
AU - Sattar, Naveed
AU - Relton, Caroline L
AU - Jacobsson, Bo
AU - Frayling, Timothy M
AU - Sørensen, Thorkild I A
AU - Murray, Jeffrey C
AU - Lawlor, Debbie A
AU - Pennell, Craig E
AU - Jaddoe, Vincent W V
AU - Hypponen, Elina
AU - Lowe, William L
AU - Jarvelin, Marjo-Riitta
AU - Davey Smith, George
AU - Freathy, Rachel M
AU - Early Growth Genetics (EGG) Consortium
PY - 2012
Y1 - 2012
N2 - Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P = 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4-36 g] lower birth weight (P = 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: -4 to 14 g; P = 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight.
AB - Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P = 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4-36 g] lower birth weight (P = 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: -4 to 14 g; P = 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight.
U2 - 10.1093/hmg/dds372
DO - 10.1093/hmg/dds372
M3 - Journal article
VL - 21
SP - 5344
EP - 5358
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 24
ER -
ID: 48585213