Genome sequencing reveals insights into physiology and longevity of the naked mole rat
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Genome sequencing reveals insights into physiology and longevity of the naked mole rat. / Kim, Eun Bae; Fang, Xiaodong; Fushan, Alexey A; Huang, Zhiyong; Lobanov, Alexei V; Han, Lijuan; Marino, Stefano M; Sun, Xiaoqing; Turanov, Anton A; Yang, Pengcheng; Yim, Sun Hee; Zhao, Xiang; Kasaikina, Marina V; Stoletzki, Nina; Peng, Chunfang; Polak, Paz; Xiong, Zhiqiang; Kiezun, Adam; Zhu, Yabing; Chen, Yuanxin; Kryukov, Gregory V; Zhang, Qiang; Peshkin, Leonid; Yang, Lan; Bronson, Roderick T; Buffenstein, Rochelle; Wang, Bo; Han, Changlei; Li, Qiye; Chen, Li; Zhao, Wei; Sunyaev, Shamil R; Park, Thomas J; Zhang, Guojie; Wang, Jun; Gladyshev, Vadim N.
In: Nature Photographer, Vol. 479, No. 7372, 2011, p. 223-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genome sequencing reveals insights into physiology and longevity of the naked mole rat
AU - Kim, Eun Bae
AU - Fang, Xiaodong
AU - Fushan, Alexey A
AU - Huang, Zhiyong
AU - Lobanov, Alexei V
AU - Han, Lijuan
AU - Marino, Stefano M
AU - Sun, Xiaoqing
AU - Turanov, Anton A
AU - Yang, Pengcheng
AU - Yim, Sun Hee
AU - Zhao, Xiang
AU - Kasaikina, Marina V
AU - Stoletzki, Nina
AU - Peng, Chunfang
AU - Polak, Paz
AU - Xiong, Zhiqiang
AU - Kiezun, Adam
AU - Zhu, Yabing
AU - Chen, Yuanxin
AU - Kryukov, Gregory V
AU - Zhang, Qiang
AU - Peshkin, Leonid
AU - Yang, Lan
AU - Bronson, Roderick T
AU - Buffenstein, Rochelle
AU - Wang, Bo
AU - Han, Changlei
AU - Li, Qiye
AU - Chen, Li
AU - Zhao, Wei
AU - Sunyaev, Shamil R
AU - Park, Thomas J
AU - Zhang, Guojie
AU - Wang, Jun
AU - Gladyshev, Vadim N
PY - 2011
Y1 - 2011
N2 - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.
AB - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.
KW - Adaptation, Physiological
KW - Aging
KW - Amino Acid Sequence
KW - Animals
KW - Body Temperature Regulation
KW - Carbon Dioxide
KW - Circadian Rhythm
KW - Darkness
KW - Genes
KW - Genome
KW - Genomic Instability
KW - Genomics
KW - Humans
KW - Ion Channels
KW - Longevity
KW - Male
KW - Mitochondrial Proteins
KW - Mole Rats
KW - Molecular Sequence Data
KW - Mutagenesis
KW - Oxygen
KW - Taste
KW - Transcriptome
KW - Visual Perception
U2 - 10.1038/nature10533
DO - 10.1038/nature10533
M3 - Journal article
C2 - 21993625
VL - 479
SP - 223
EP - 227
JO - Nature Photographer
JF - Nature Photographer
SN - 1049-6602
IS - 7372
ER -
ID: 43544411