GHR knockout and the CNS

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GHR knockout and the CNS. / Gosney, Elahu S.; Kopchick, John J.

Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience. Springer Berlin/Heidelberg, 2011. p. 489-493.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Gosney, ES & Kopchick, JJ 2011, GHR knockout and the CNS. in Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience. Springer Berlin/Heidelberg, pp. 489-493. https://doi.org/10.1007/978-3-642-11183-9_56

APA

Gosney, E. S., & Kopchick, J. J. (2011). GHR knockout and the CNS. In Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience (pp. 489-493). Springer Berlin/Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_56

Vancouver

Gosney ES, Kopchick JJ. GHR knockout and the CNS. In Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience. Springer Berlin/Heidelberg. 2011. p. 489-493 https://doi.org/10.1007/978-3-642-11183-9_56

Author

Gosney, Elahu S. ; Kopchick, John J. / GHR knockout and the CNS. Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience. Springer Berlin/Heidelberg, 2011. pp. 489-493

Bibtex

@inbook{4e17ce74110041ebb11829de877b8c58,
title = "GHR knockout and the CNS",
abstract = "The GHR -/- mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR-/- mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues. The disruption of GH signaling alters the feedback mechanisms that control GH expression. This results in changes in expression of several hypothalamic proteins that influence GH expression and also results in structural changes in the pituitary. Several measures of motorneuron development were unaltered in the GHR-/- mouse, indicating this is a GH-independent process. An examination of the brain of GHR-/- animals shows increased neuron cell density and hypoplasia of glial cells compared to controls. The single investigation of cognition in these animals has shown protection from age-related decline in memory in the GHR-/- mice. There is a great opportunity to use these mice to facilitate further research into the role GH plays in neural development and function.",
author = "Gosney, {Elahu S.} and Kopchick, {John J.}",
year = "2011",
month = dec,
day = "1",
doi = "10.1007/978-3-642-11183-9_56",
language = "English",
isbn = "9783642111822",
pages = "489--493",
booktitle = "Laron Syndrome - From Man to Mouse",
publisher = "Springer Berlin/Heidelberg",

}

RIS

TY - CHAP

T1 - GHR knockout and the CNS

AU - Gosney, Elahu S.

AU - Kopchick, John J.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The GHR -/- mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR-/- mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues. The disruption of GH signaling alters the feedback mechanisms that control GH expression. This results in changes in expression of several hypothalamic proteins that influence GH expression and also results in structural changes in the pituitary. Several measures of motorneuron development were unaltered in the GHR-/- mouse, indicating this is a GH-independent process. An examination of the brain of GHR-/- animals shows increased neuron cell density and hypoplasia of glial cells compared to controls. The single investigation of cognition in these animals has shown protection from age-related decline in memory in the GHR-/- mice. There is a great opportunity to use these mice to facilitate further research into the role GH plays in neural development and function.

AB - The GHR -/- mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR-/- mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues. The disruption of GH signaling alters the feedback mechanisms that control GH expression. This results in changes in expression of several hypothalamic proteins that influence GH expression and also results in structural changes in the pituitary. Several measures of motorneuron development were unaltered in the GHR-/- mouse, indicating this is a GH-independent process. An examination of the brain of GHR-/- animals shows increased neuron cell density and hypoplasia of glial cells compared to controls. The single investigation of cognition in these animals has shown protection from age-related decline in memory in the GHR-/- mice. There is a great opportunity to use these mice to facilitate further research into the role GH plays in neural development and function.

UR - http://www.scopus.com/inward/record.url?scp=84895368755&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-11183-9_56

DO - 10.1007/978-3-642-11183-9_56

M3 - Book chapter

AN - SCOPUS:84895368755

SN - 9783642111822

SP - 489

EP - 493

BT - Laron Syndrome - From Man to Mouse

PB - Springer Berlin/Heidelberg

ER -

ID: 202371745