High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. / Clausen, Tine D; Mathiesen, Elisabeth R; Hansen, Torben; Pedersen, Oluf; Jensen, Dorte M; Lauenborg, Jeannet; Damm, Peter; Clausen, Tine Dalsgaard; Mathiesen, Elisabeth R; Hansen, Torben; Pedersen, Oluf; Jensen, Dorte; Lauenborg, Jeannet; Damm, Peter.

In: Diabetes Care, Vol. 31, No. 2, 01.02.2008, p. 340-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Clausen, TD, Mathiesen, ER, Hansen, T, Pedersen, O, Jensen, DM, Lauenborg, J, Damm, P, Clausen, TD, Mathiesen, ER, Hansen, T, Pedersen, O, Jensen, D, Lauenborg, J & Damm, P 2008, 'High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia', Diabetes Care, vol. 31, no. 2, pp. 340-6. https://doi.org/10.2337/dc07-1596, https://doi.org/10.2337/dc07-1596

APA

Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O., Jensen, D. M., Lauenborg, J., Damm, P., Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O., Jensen, D., Lauenborg, J., & Damm, P. (2008). High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. Diabetes Care, 31(2), 340-6. https://doi.org/10.2337/dc07-1596, https://doi.org/10.2337/dc07-1596

Vancouver

Clausen TD, Mathiesen ER, Hansen T, Pedersen O, Jensen DM, Lauenborg J et al. High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. Diabetes Care. 2008 Feb 1;31(2):340-6. https://doi.org/10.2337/dc07-1596, https://doi.org/10.2337/dc07-1596

Author

Clausen, Tine D ; Mathiesen, Elisabeth R ; Hansen, Torben ; Pedersen, Oluf ; Jensen, Dorte M ; Lauenborg, Jeannet ; Damm, Peter ; Clausen, Tine Dalsgaard ; Mathiesen, Elisabeth R ; Hansen, Torben ; Pedersen, Oluf ; Jensen, Dorte ; Lauenborg, Jeannet ; Damm, Peter. / High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. In: Diabetes Care. 2008 ; Vol. 31, No. 2. pp. 340-6.

Bibtex

@article{00e75e30ee2011ddbf70000ea68e967b,
title = "High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia",
abstract = "OBJECTIVE: The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated. We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account. RESEARCH DESIGN AND METHODS: The glucose tolerance status following a 2-h 75-g oral glucose tolerance test (OGTT) was evaluated in 597 subjects, primarily Caucasians, aged 18-27 years. They were subdivided into four groups according to maternal glucose metabolism during pregnancy and genetic predisposition to type 2 diabetes: 1) offspring of women with diet-treated GDM (O-GDM), 2) offspring of genetically predisposed women with a normal OGTT (O-NoGDM), 3) offspring of women with type 1 diabetes (O-type 1), and 4) offspring of women from the background population (O-BP). RESULTS: The prevalence of type 2 diabetes and pre-diabetes (impaired glucose tolerance or impaired fasting glucose) in the four groups was 21, 12, 11, and 4%, respectively. In multiple logistic regression analysis, the adjusted odds ratios (ORs) for type 2 diabetes/pre-diabetes were 7.76 (95% CI 2.58-23.39) in O-GDM and 4.02 (1.31-12.33) in O-type 1 compared with O-BP. In O-type 1, the risk of type 2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy: OR 1.41 (1.04-1.91) per mmol/l. CONCLUSIONS: A hyperglycemic intrauterine environment appears to be involved in the pathogenesis of type 2 diabetes/pre-diabetes in adult offspring of primarily Caucasian women with either diet-treated GDM or type 1 diabetes during pregnancy.",
author = "Clausen, {Tine D} and Mathiesen, {Elisabeth R} and Torben Hansen and Oluf Pedersen and Jensen, {Dorte M} and Jeannet Lauenborg and Peter Damm and Clausen, {Tine Dalsgaard} and Mathiesen, {Elisabeth R} and Torben Hansen and Oluf Pedersen and Dorte Jensen and Jeannet Lauenborg and Peter Damm",
note = "Keywords: Adult; Denmark; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Genetic Predisposition to Disease; Glucose Tolerance Test; Humans; Hyperglycemia; Overweight; Prediabetic State; Pregnancy; Pregnancy Complications; Regression Analysis; Smoking",
year = "2008",
month = feb,
day = "1",
doi = "10.2337/dc07-1596",
language = "English",
volume = "31",
pages = "340--6",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "2",

}

RIS

TY - JOUR

T1 - High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia

AU - Clausen, Tine D

AU - Mathiesen, Elisabeth R

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Jensen, Dorte M

AU - Lauenborg, Jeannet

AU - Damm, Peter

AU - Clausen, Tine Dalsgaard

AU - Mathiesen, Elisabeth R

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Jensen, Dorte

AU - Lauenborg, Jeannet

AU - Damm, Peter

N1 - Keywords: Adult; Denmark; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Genetic Predisposition to Disease; Glucose Tolerance Test; Humans; Hyperglycemia; Overweight; Prediabetic State; Pregnancy; Pregnancy Complications; Regression Analysis; Smoking

PY - 2008/2/1

Y1 - 2008/2/1

N2 - OBJECTIVE: The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated. We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account. RESEARCH DESIGN AND METHODS: The glucose tolerance status following a 2-h 75-g oral glucose tolerance test (OGTT) was evaluated in 597 subjects, primarily Caucasians, aged 18-27 years. They were subdivided into four groups according to maternal glucose metabolism during pregnancy and genetic predisposition to type 2 diabetes: 1) offspring of women with diet-treated GDM (O-GDM), 2) offspring of genetically predisposed women with a normal OGTT (O-NoGDM), 3) offspring of women with type 1 diabetes (O-type 1), and 4) offspring of women from the background population (O-BP). RESULTS: The prevalence of type 2 diabetes and pre-diabetes (impaired glucose tolerance or impaired fasting glucose) in the four groups was 21, 12, 11, and 4%, respectively. In multiple logistic regression analysis, the adjusted odds ratios (ORs) for type 2 diabetes/pre-diabetes were 7.76 (95% CI 2.58-23.39) in O-GDM and 4.02 (1.31-12.33) in O-type 1 compared with O-BP. In O-type 1, the risk of type 2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy: OR 1.41 (1.04-1.91) per mmol/l. CONCLUSIONS: A hyperglycemic intrauterine environment appears to be involved in the pathogenesis of type 2 diabetes/pre-diabetes in adult offspring of primarily Caucasian women with either diet-treated GDM or type 1 diabetes during pregnancy.

AB - OBJECTIVE: The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated. We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account. RESEARCH DESIGN AND METHODS: The glucose tolerance status following a 2-h 75-g oral glucose tolerance test (OGTT) was evaluated in 597 subjects, primarily Caucasians, aged 18-27 years. They were subdivided into four groups according to maternal glucose metabolism during pregnancy and genetic predisposition to type 2 diabetes: 1) offspring of women with diet-treated GDM (O-GDM), 2) offspring of genetically predisposed women with a normal OGTT (O-NoGDM), 3) offspring of women with type 1 diabetes (O-type 1), and 4) offspring of women from the background population (O-BP). RESULTS: The prevalence of type 2 diabetes and pre-diabetes (impaired glucose tolerance or impaired fasting glucose) in the four groups was 21, 12, 11, and 4%, respectively. In multiple logistic regression analysis, the adjusted odds ratios (ORs) for type 2 diabetes/pre-diabetes were 7.76 (95% CI 2.58-23.39) in O-GDM and 4.02 (1.31-12.33) in O-type 1 compared with O-BP. In O-type 1, the risk of type 2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy: OR 1.41 (1.04-1.91) per mmol/l. CONCLUSIONS: A hyperglycemic intrauterine environment appears to be involved in the pathogenesis of type 2 diabetes/pre-diabetes in adult offspring of primarily Caucasian women with either diet-treated GDM or type 1 diabetes during pregnancy.

U2 - 10.2337/dc07-1596

DO - 10.2337/dc07-1596

M3 - Journal article

C2 - 18000174

VL - 31

SP - 340

EP - 346

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 2

ER -

ID: 10001365