IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
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IL6 gene promoter polymorphisms and type 2 diabetes : joint analysis of individual participants' data from 21 studies. / Huth, Cornelia; Heid, Iris M; Vollmert, Caren; Gieger, Christian; Grallert, Harald; Wolford, Johanna K; Langer, Birgit; Thorand, Barbara; Klopp, Norman; Hamid, Yasmin H; Pedersen, Oluf; Hansen, Torben; Lyssenko, Valeriya; Groop, Leif; Meisinger, Christa; Döring, Angela; Löwel, Hannelore; Lieb, Wolfgang; Hengstenberg, Christian; Rathmann, Wolfgang; Martin, Stephan; Stephens, Jeffrey W; Ireland, Helen; Mather, Hugh; Miller, George J; Stringham, Heather M; Boehnke, Michael; Tuomilehto, Jaakko; Boeing, Heiner; Möhlig, Matthias; Spranger, Joachim; Pfeiffer, Andreas; Wernstedt, Ingrid; Niklason, Anders; López-Bermejo, Abel; Fernández-Real, José-Manuel; Hanson, Robert L; Gallart, Luis; Vendrell, Joan; Tsiavou, Anastasia; Hatziagelaki, Erifili; Humphries, Steve E; Wichmann, H-Erich; Herder, Christian; Illig, Thomas.
In: Diabetes, Vol. 55, No. 10, 2006, p. 2915-21.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - IL6 gene promoter polymorphisms and type 2 diabetes
T2 - joint analysis of individual participants' data from 21 studies
AU - Huth, Cornelia
AU - Heid, Iris M
AU - Vollmert, Caren
AU - Gieger, Christian
AU - Grallert, Harald
AU - Wolford, Johanna K
AU - Langer, Birgit
AU - Thorand, Barbara
AU - Klopp, Norman
AU - Hamid, Yasmin H
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - Meisinger, Christa
AU - Döring, Angela
AU - Löwel, Hannelore
AU - Lieb, Wolfgang
AU - Hengstenberg, Christian
AU - Rathmann, Wolfgang
AU - Martin, Stephan
AU - Stephens, Jeffrey W
AU - Ireland, Helen
AU - Mather, Hugh
AU - Miller, George J
AU - Stringham, Heather M
AU - Boehnke, Michael
AU - Tuomilehto, Jaakko
AU - Boeing, Heiner
AU - Möhlig, Matthias
AU - Spranger, Joachim
AU - Pfeiffer, Andreas
AU - Wernstedt, Ingrid
AU - Niklason, Anders
AU - López-Bermejo, Abel
AU - Fernández-Real, José-Manuel
AU - Hanson, Robert L
AU - Gallart, Luis
AU - Vendrell, Joan
AU - Tsiavou, Anastasia
AU - Hatziagelaki, Erifili
AU - Humphries, Steve E
AU - Wichmann, H-Erich
AU - Herder, Christian
AU - Illig, Thomas
PY - 2006
Y1 - 2006
N2 - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
AB - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
KW - Case-Control Studies
KW - Diabetes Mellitus, Type 2
KW - Genetics, Population
KW - Humans
KW - Interleukin-6
KW - Odds Ratio
KW - Polymorphism, Genetic
KW - Promoter Regions, Genetic
KW - Risk
U2 - 10.2337/db06-0600
DO - 10.2337/db06-0600
M3 - Journal article
C2 - 17003362
VL - 55
SP - 2915
EP - 2921
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 10
ER -
ID: 38336462