Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. / Molinaro, Antonio; Bel Lassen, Pierre; Henricsson, Marcus; Wu, Hao; Adriouch, Solia; Belda, Eugeni; Chakaroun, Rima; Nielsen, Trine; Bergh, Per-Olof; Rouault, Christine; Andre, Sebastien; Marquet, Florian; Andreelli, Fabrizio; Salem, Joe-Elie; Assmann, Karen; Bastard, Jean-Philippe; Forslund, Sofia; Le Chatelier, Emmanuelle; Falony, Gwen; Pons, Nicolas; Prifti, Edi; Quinquis, Benoit; Roume, Hugo; Vieira-Silva, Sara; Hansen, Tue H.; Pedersen, Helle Krogh; Lewinter, Christian; Sønderskov, Nadja B.; Køber, Lars; Vestergaard, Henrik; Hansen, Torben; Zucker, Jean-Daniel; Galan, Pilar; Dumas, Marc-Emmanuel; Raes, Jeroen; Oppert, Jean-Michel; Letunic, Ivica; Nielsen, Jens; Bork, Peer; Ehrlich, S. Dusko; Stumvoll, Michael; Pedersen, Oluf; Aron-Wisneswky, Judith; Clement, Karine; Baeckhed, Fredrik; MetaCardis Consortium.

In: Nature Communications, Vol. 11, No. 1, 5881, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Molinaro, A, Bel Lassen, P, Henricsson, M, Wu, H, Adriouch, S, Belda, E, Chakaroun, R, Nielsen, T, Bergh, P-O, Rouault, C, Andre, S, Marquet, F, Andreelli, F, Salem, J-E, Assmann, K, Bastard, J-P, Forslund, S, Le Chatelier, E, Falony, G, Pons, N, Prifti, E, Quinquis, B, Roume, H, Vieira-Silva, S, Hansen, TH, Pedersen, HK, Lewinter, C, Sønderskov, NB, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Galan, P, Dumas, M-E, Raes, J, Oppert, J-M, Letunic, I, Nielsen, J, Bork, P, Ehrlich, SD, Stumvoll, M, Pedersen, O, Aron-Wisneswky, J, Clement, K, Baeckhed, F & MetaCardis Consortium 2020, 'Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology', Nature Communications, vol. 11, no. 1, 5881. https://doi.org/10.1038/s41467-020-19589-w

APA

Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P-O., Rouault, C., Andre, S., Marquet, F., Andreelli, F., Salem, J-E., Assmann, K., Bastard, J-P., Forslund, S., Le Chatelier, E., Falony, G., ... MetaCardis Consortium (2020). Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications, 11(1), [5881]. https://doi.org/10.1038/s41467-020-19589-w

Vancouver

Molinaro A, Bel Lassen P, Henricsson M, Wu H, Adriouch S, Belda E et al. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications. 2020;11(1). 5881. https://doi.org/10.1038/s41467-020-19589-w

Author

Molinaro, Antonio ; Bel Lassen, Pierre ; Henricsson, Marcus ; Wu, Hao ; Adriouch, Solia ; Belda, Eugeni ; Chakaroun, Rima ; Nielsen, Trine ; Bergh, Per-Olof ; Rouault, Christine ; Andre, Sebastien ; Marquet, Florian ; Andreelli, Fabrizio ; Salem, Joe-Elie ; Assmann, Karen ; Bastard, Jean-Philippe ; Forslund, Sofia ; Le Chatelier, Emmanuelle ; Falony, Gwen ; Pons, Nicolas ; Prifti, Edi ; Quinquis, Benoit ; Roume, Hugo ; Vieira-Silva, Sara ; Hansen, Tue H. ; Pedersen, Helle Krogh ; Lewinter, Christian ; Sønderskov, Nadja B. ; Køber, Lars ; Vestergaard, Henrik ; Hansen, Torben ; Zucker, Jean-Daniel ; Galan, Pilar ; Dumas, Marc-Emmanuel ; Raes, Jeroen ; Oppert, Jean-Michel ; Letunic, Ivica ; Nielsen, Jens ; Bork, Peer ; Ehrlich, S. Dusko ; Stumvoll, Michael ; Pedersen, Oluf ; Aron-Wisneswky, Judith ; Clement, Karine ; Baeckhed, Fredrik ; MetaCardis Consortium. / Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{7bd563c5350648babb6ce6a6970a8656,
title = "Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology",
abstract = "Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.",
keywords = "HOMEOSTASIS MODEL ASSESSMENT, INTESTINAL MICROBIOTA, INSULIN SENSITIVITY, ACCURATE METHOD, GUT MICROBIOME, GLUCOSE, INDIVIDUALS, RISK, METAGENOME, PHYSIOLOGY",
author = "Antonio Molinaro and {Bel Lassen}, Pierre and Marcus Henricsson and Hao Wu and Solia Adriouch and Eugeni Belda and Rima Chakaroun and Trine Nielsen and Per-Olof Bergh and Christine Rouault and Sebastien Andre and Florian Marquet and Fabrizio Andreelli and Joe-Elie Salem and Karen Assmann and Jean-Philippe Bastard and Sofia Forslund and {Le Chatelier}, Emmanuelle and Gwen Falony and Nicolas Pons and Edi Prifti and Benoit Quinquis and Hugo Roume and Sara Vieira-Silva and Hansen, {Tue H.} and Pedersen, {Helle Krogh} and Christian Lewinter and S{\o}nderskov, {Nadja B.} and Lars K{\o}ber and Henrik Vestergaard and Torben Hansen and Jean-Daniel Zucker and Pilar Galan and Marc-Emmanuel Dumas and Jeroen Raes and Jean-Michel Oppert and Ivica Letunic and Jens Nielsen and Peer Bork and Ehrlich, {S. Dusko} and Michael Stumvoll and Oluf Pedersen and Judith Aron-Wisneswky and Karine Clement and Fredrik Baeckhed and {MetaCardis Consortium}",
year = "2020",
doi = "10.1038/s41467-020-19589-w",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

AU - Molinaro, Antonio

AU - Bel Lassen, Pierre

AU - Henricsson, Marcus

AU - Wu, Hao

AU - Adriouch, Solia

AU - Belda, Eugeni

AU - Chakaroun, Rima

AU - Nielsen, Trine

AU - Bergh, Per-Olof

AU - Rouault, Christine

AU - Andre, Sebastien

AU - Marquet, Florian

AU - Andreelli, Fabrizio

AU - Salem, Joe-Elie

AU - Assmann, Karen

AU - Bastard, Jean-Philippe

AU - Forslund, Sofia

AU - Le Chatelier, Emmanuelle

AU - Falony, Gwen

AU - Pons, Nicolas

AU - Prifti, Edi

AU - Quinquis, Benoit

AU - Roume, Hugo

AU - Vieira-Silva, Sara

AU - Hansen, Tue H.

AU - Pedersen, Helle Krogh

AU - Lewinter, Christian

AU - Sønderskov, Nadja B.

AU - Køber, Lars

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Zucker, Jean-Daniel

AU - Galan, Pilar

AU - Dumas, Marc-Emmanuel

AU - Raes, Jeroen

AU - Oppert, Jean-Michel

AU - Letunic, Ivica

AU - Nielsen, Jens

AU - Bork, Peer

AU - Ehrlich, S. Dusko

AU - Stumvoll, Michael

AU - Pedersen, Oluf

AU - Aron-Wisneswky, Judith

AU - Clement, Karine

AU - Baeckhed, Fredrik

AU - MetaCardis Consortium

PY - 2020

Y1 - 2020

N2 - Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

AB - Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

KW - HOMEOSTASIS MODEL ASSESSMENT

KW - INTESTINAL MICROBIOTA

KW - INSULIN SENSITIVITY

KW - ACCURATE METHOD

KW - GUT MICROBIOME

KW - GLUCOSE

KW - INDIVIDUALS

KW - RISK

KW - METAGENOME

KW - PHYSIOLOGY

U2 - 10.1038/s41467-020-19589-w

DO - 10.1038/s41467-020-19589-w

M3 - Journal article

C2 - 33208748

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5881

ER -

ID: 253446485