Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology

Research output: Contribution to journal › Review › Research › peer-review

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Know your neighbor : Microbiota and host epithelial cells interact locally to control intestinal function and physiology. / Sommer, Felix; Bäckhed, Gert Fredrik.

In: BioEssays, Vol. 38, No. 5, 18.03.2016, p. 455-464.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Sommer, F & Bäckhed, GF 2016, 'Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology', BioEssays, vol. 38, no. 5, pp. 455-464. https://doi.org/10.1002/bies.201500151

APA

Sommer, F., & Bäckhed, G. F. (2016). Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. BioEssays, 38(5), 455-464. https://doi.org/10.1002/bies.201500151

Vancouver

Sommer F, Bäckhed GF. Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. BioEssays. 2016 Mar 18;38(5):455-464. https://doi.org/10.1002/bies.201500151

Author

Sommer, Felix ; Bäckhed, Gert Fredrik. / Know your neighbor : Microbiota and host epithelial cells interact locally to control intestinal function and physiology. In: BioEssays. 2016 ; Vol. 38, No. 5. pp. 455-464.

Bibtex

@article{176f7294b4e746b3aade8b28548c0b6b,
title = "Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology",
abstract = "Interactions between the host and its associated microbiota differ spatially and the local cross talk determines organ function and physiology. Animals and their organs are not uniform but contain several functional and cellular compartments and gradients. In the intestinal tract, different parts of the gut carry out different functions, tissue structure varies accordingly, epithelial cells are differentially distributed and gradients exist for several physicochemical parameters such as nutrients, pH, or oxygen. Consequently, the microbiota composition also differs along the length of the gut, but also between lumen and mucosa of the same intestinal segment, and even along the crypt-villus axis in the epithelium. Thus, host-microbiota interactions are highly site-specific and the local cross talk determines intestinal function and physiology. Here we review recent advances in our understanding of site-specific host-microbiota interactions and discuss their functional relevance for host physiology.",
author = "Felix Sommer and B{\"a}ckhed, {Gert Fredrik}",
note = "{\textcopyright} 2016 WILEY Periodicals, Inc.",
year = "2016",
month = mar,
day = "18",
doi = "10.1002/bies.201500151",
language = "English",
volume = "38",
pages = "455--464",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Know your neighbor

T2 - Microbiota and host epithelial cells interact locally to control intestinal function and physiology

AU - Sommer, Felix

AU - Bäckhed, Gert Fredrik

N1 - © 2016 WILEY Periodicals, Inc.

PY - 2016/3/18

Y1 - 2016/3/18

N2 - Interactions between the host and its associated microbiota differ spatially and the local cross talk determines organ function and physiology. Animals and their organs are not uniform but contain several functional and cellular compartments and gradients. In the intestinal tract, different parts of the gut carry out different functions, tissue structure varies accordingly, epithelial cells are differentially distributed and gradients exist for several physicochemical parameters such as nutrients, pH, or oxygen. Consequently, the microbiota composition also differs along the length of the gut, but also between lumen and mucosa of the same intestinal segment, and even along the crypt-villus axis in the epithelium. Thus, host-microbiota interactions are highly site-specific and the local cross talk determines intestinal function and physiology. Here we review recent advances in our understanding of site-specific host-microbiota interactions and discuss their functional relevance for host physiology.

AB - Interactions between the host and its associated microbiota differ spatially and the local cross talk determines organ function and physiology. Animals and their organs are not uniform but contain several functional and cellular compartments and gradients. In the intestinal tract, different parts of the gut carry out different functions, tissue structure varies accordingly, epithelial cells are differentially distributed and gradients exist for several physicochemical parameters such as nutrients, pH, or oxygen. Consequently, the microbiota composition also differs along the length of the gut, but also between lumen and mucosa of the same intestinal segment, and even along the crypt-villus axis in the epithelium. Thus, host-microbiota interactions are highly site-specific and the local cross talk determines intestinal function and physiology. Here we review recent advances in our understanding of site-specific host-microbiota interactions and discuss their functional relevance for host physiology.

U2 - 10.1002/bies.201500151

DO - 10.1002/bies.201500151

M3 - Review

C2 - 26990415

VL - 38

SP - 455

EP - 464

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 5

ER -

ID: 159743462