Standard
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. / Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory; Broer, Linda; Johnson, Toby; Koller, Daniel L; Kutalik, Zoltán; Luan, Jian'an; Malkin, Ida; Ried, Janina S; Smith, Albert V; Thorleifsson, Gudmar; Vandenput, Liesbeth; Hua Zhao, Jing; Zhang, Weihua; Aghdassi, Ali; Åkesson, Kristina; Amin, Najaf; Baier, Leslie J; Barroso, Inês; Bennett, David A; Bertram, Lars; Biffar, Rainer; Bochud, Murielle; Boehnke, Michael; Borecki, Ingrid B; Buchman, Aron S; Byberg, Liisa; Campbell, Harry; Campos Obanda, Natalia; Cauley, Jane A; Cawthon, Peggy M; Cederberg, Henna; Chen, Zhao; Cho, Nam H; Jin Choi, Hyung; Claussnitzer, Melina; Collins, Francis; Cummings, Steven R; De Jager, Philip L; Demuth, Ilja; Dhonukshe-Rutten, Rosalie A M; Diatchenko, Luda; Eiriksdottir, Gudny; Enneman, Anke W; Erdos, Mike; Eriksson, Johan G; Eriksson, Joel; Estrada, Karol; Evans, Daniel S; Feitosa, Mary F; Fu, Mao; Garcia, Melissa; Gieger, Christian; Girke, Thomas; Glazer, Nicole L; Grallert, Harald; Grewal, Jagvir; Han, Bok-Ghee; Hanson, Robert L; Hayward, Caroline; Hofman, Albert; Hoffman, Eric P; Homuth, Georg; Hsueh, Wen-Chi; Hubal, Monica J; Hubbard, Alan; Huffman, Kim M; Husted, Lise B; Illig, Thomas; Ingelsson, Erik; Ittermann, Till; Jansson, John-Olov; Jordan, Joanne M; Jula, Antti; Karlsson, Magnus; Khaw, Kay-Tee; Kilpeläinen, Tuomas O; Klopp, Norman; Kloth, Jacqueline S L; Koistinen, Heikki A; Kraus, William E; Kritchevsky, Stephen; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku; Lahti, Jari; Lang, Thomas; Langdahl, Bente L; Launer, Lenore J; Lee, Jong-Young; Lerch, Markus M; Lewis, Joshua R; Lind, Lars; Lindgren, Cecilia; Liu, Yongmei; Liu, Tian; Liu, Youfang; Ljunggren, Östen; Lorentzon, Mattias; Luben, Robert N; Maixner, William; McGuigan, Fiona E; Medina-Gomez, Carolina; Meitinger, Thomas; Melhus, Håkan; Mellström, Dan; Melov, Simon; Michaëlsson, Karl; Mitchell, Braxton D; Morris, Andrew P; Mosekilde, Leif; Newman, Anne; Nielson, Carrie M; O'Connell, Jeffrey R; Oostra, Ben A; Orwoll, Eric S; Palotie, Aarno; Parker, Stephan; Peacock, Munro; Perola, Markus; Peters, Annette; Polasek, Ozren; Prince, Richard L; Räikkönen, Katri; Ralston, Stuart H; Ripatti, Samuli; Robbins, John A; Rotter, Jerome I; Rudan, Igor; Salomaa, Veikko; Satterfield, Suzanne; Schadt, Eric E; Schipf, Sabine; Scott, Laura; Sehmi, Joban; Shen, Jian; Soo Shin, Chan; Sigurdsson, Gunnar; Smith, Shad; Soranzo, Nicole; Stančáková, Alena; Steinhagen-Thiessen, Elisabeth; Streeten, Elizabeth A; Styrkarsdottir, Unnur; Swart, Karin M A; Tan, Sian-Tsung; Tarnopolsky, Mark A; Thompson, Patricia; Thomson, Cynthia A; Thorsteinsdottir, Unnur; Tikkanen, Emmi; Tranah, Gregory J; Tuomilehto, Jaakko; van Schoor, Natasja M; Verma, Arjun; Vollenweider, Peter; Völzke, Henry; Wactawski-Wende, Jean; Walker, Mark; Weedon, Michael N; Welch, Ryan; Wichmann, H-Erich; Widen, Elisabeth; Williams, Frances M K; Wilson, James F; Wright, Nicole C; Xie, Weijia; Yu, Lei; Zhou, Yanhua; Chambers, John C; Döring, Angela; van Duijn, Cornelia M; Econs, Michael J; Gudnason, Vilmundur; Kooner, Jaspal S; Psaty, Bruce M; Spector, Timothy D; Stefansson, Kari; Rivadeneira, Fernando; Uitterlinden, André G; Wareham, Nicholas J; Ossowski, Vicky; Waterworth, Dawn; Loos, Ruth J F; Karasik, David; Harris, Tamara B; Ohlsson, Claes; Kiel, Douglas P.
In:
Nature Communications, Vol. 8, 80, 19.07.2017.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Zillikens, MC, Demissie, S, Hsu, Y-H, Yerges-Armstrong, LM, Chou, W-C, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A, Åkesson, K, Amin, N, Baier, LJ, Barroso, I, Bennett, DA, Bertram, L, Biffar, R, Bochud, M, Boehnke, M, Borecki, IB, Buchman, AS, Byberg, L, Campbell, H, Campos Obanda, N, Cauley, JA, Cawthon, PM, Cederberg, H, Chen, Z, Cho, NH, Jin Choi, H, Claussnitzer, M, Collins, F, Cummings, SR, De Jager, PL, Demuth, I, Dhonukshe-Rutten, RAM, Diatchenko, L, Eiriksdottir, G, Enneman, AW, Erdos, M, Eriksson, JG, Eriksson, J, Estrada, K, Evans, DS, Feitosa, MF, Fu, M, Garcia, M, Gieger, C, Girke, T, Glazer, NL, Grallert, H, Grewal, J, Han, B-G, Hanson, RL, Hayward, C, Hofman, A, Hoffman, EP, Homuth, G, Hsueh, W-C, Hubal, MJ, Hubbard, A, Huffman, KM, Husted, LB, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Jordan, JM, Jula, A, Karlsson, M, Khaw, K-T
, Kilpeläinen, TO, Klopp, N, Kloth, JSL, Koistinen, HA, Kraus, WE, Kritchevsky, S, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, BL, Launer, LJ, Lee, J-Y, Lerch, MM, Lewis, JR, Lind, L, Lindgren, C, Liu, Y, Liu, T, Liu, Y, Ljunggren, Ö, Lorentzon, M, Luben, RN, Maixner, W, McGuigan, FE, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Melov, S, Michaëlsson, K, Mitchell, BD, Morris, AP, Mosekilde, L, Newman, A, Nielson, CM, O'Connell, JR, Oostra, BA, Orwoll, ES, Palotie, A, Parker, S, Peacock, M, Perola, M, Peters, A, Polasek, O, Prince, RL, Räikkönen, K, Ralston, SH, Ripatti, S, Robbins, JA, Rotter, JI, Rudan, I, Salomaa, V, Satterfield, S, Schadt, EE, Schipf, S, Scott, L, Sehmi, J, Shen, J, Soo Shin, C, Sigurdsson, G, Smith, S, Soranzo, N, Stančáková, A, Steinhagen-Thiessen, E, Streeten, EA, Styrkarsdottir, U, Swart, KMA, Tan, S-T, Tarnopolsky, MA, Thompson, P, Thomson, CA, Thorsteinsdottir, U, Tikkanen, E, Tranah, GJ, Tuomilehto, J, van Schoor, NM, Verma, A, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, Weedon, MN, Welch, R, Wichmann, H-E, Widen, E, Williams, FMK, Wilson, JF, Wright, NC, Xie, W, Yu, L, Zhou, Y, Chambers, JC, Döring, A, van Duijn, CM, Econs, MJ, Gudnason, V, Kooner, JS, Psaty, BM, Spector, TD, Stefansson, K, Rivadeneira, F, Uitterlinden, AG, Wareham, NJ, Ossowski, V, Waterworth, D, Loos, RJF, Karasik, D, Harris, TB, Ohlsson, C & Kiel, DP 2017, '
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass',
Nature Communications, vol. 8, 80.
https://doi.org/10.1038/s41467-017-00031-7APA
Zillikens, M. C., Demissie, S., Hsu, Y-H., Yerges-Armstrong, L. M., Chou, W-C., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D. L., Kutalik, Z., Luan, J., Malkin, I., Ried, J. S., Smith, A. V., Thorleifsson, G., Vandenput, L., Hua Zhao, J., Zhang, W., ... Kiel, D. P. (2017).
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Nature Communications,
8, [80].
https://doi.org/10.1038/s41467-017-00031-7Vancouver
Zillikens MC, Demissie S, Hsu Y-H, Yerges-Armstrong LM, Chou W-C, Stolk L et al.
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Nature Communications. 2017 Jul 19;8. 80.
https://doi.org/10.1038/s41467-017-00031-7Author
Zillikens, M Carola ; Demissie, Serkalem ; Hsu, Yi-Hsiang ; Yerges-Armstrong, Laura M ; Chou, Wen-Chi ; Stolk, Lisette ; Livshits, Gregory ; Broer, Linda ; Johnson, Toby ; Koller, Daniel L ; Kutalik, Zoltán ; Luan, Jian'an ; Malkin, Ida ; Ried, Janina S ; Smith, Albert V ; Thorleifsson, Gudmar ; Vandenput, Liesbeth ; Hua Zhao, Jing ; Zhang, Weihua ; Aghdassi, Ali ; Åkesson, Kristina ; Amin, Najaf ; Baier, Leslie J ; Barroso, Inês ; Bennett, David A ; Bertram, Lars ; Biffar, Rainer ; Bochud, Murielle ; Boehnke, Michael ; Borecki, Ingrid B ; Buchman, Aron S ; Byberg, Liisa ; Campbell, Harry ; Campos Obanda, Natalia ; Cauley, Jane A ; Cawthon, Peggy M ; Cederberg, Henna ; Chen, Zhao ; Cho, Nam H ; Jin Choi, Hyung ; Claussnitzer, Melina ; Collins, Francis ; Cummings, Steven R ; De Jager, Philip L ; Demuth, Ilja ; Dhonukshe-Rutten, Rosalie A M ; Diatchenko, Luda ; Eiriksdottir, Gudny ; Enneman, Anke W ; Erdos, Mike ; Eriksson, Johan G ; Eriksson, Joel ; Estrada, Karol ; Evans, Daniel S ; Feitosa, Mary F ; Fu, Mao ; Garcia, Melissa ; Gieger, Christian ; Girke, Thomas ; Glazer, Nicole L ; Grallert, Harald ; Grewal, Jagvir ; Han, Bok-Ghee ; Hanson, Robert L ; Hayward, Caroline ; Hofman, Albert ; Hoffman, Eric P ; Homuth, Georg ; Hsueh, Wen-Chi ; Hubal, Monica J ; Hubbard, Alan ; Huffman, Kim M ; Husted, Lise B ; Illig, Thomas ; Ingelsson, Erik ; Ittermann, Till ; Jansson, John-Olov ; Jordan, Joanne M ; Jula, Antti ; Karlsson, Magnus ; Khaw, Kay-Tee ; Kilpeläinen, Tuomas O ; Klopp, Norman ; Kloth, Jacqueline S L ; Koistinen, Heikki A ; Kraus, William E ; Kritchevsky, Stephen ; Kuulasmaa, Teemu ; Kuusisto, Johanna ; Laakso, Markku ; Lahti, Jari ; Lang, Thomas ; Langdahl, Bente L ; Launer, Lenore J ; Lee, Jong-Young ; Lerch, Markus M ; Lewis, Joshua R ; Lind, Lars ; Lindgren, Cecilia ; Liu, Yongmei ; Liu, Tian ; Liu, Youfang ; Ljunggren, Östen ; Lorentzon, Mattias ; Luben, Robert N ; Maixner, William ; McGuigan, Fiona E ; Medina-Gomez, Carolina ; Meitinger, Thomas ; Melhus, Håkan ; Mellström, Dan ; Melov, Simon ; Michaëlsson, Karl ; Mitchell, Braxton D ; Morris, Andrew P ; Mosekilde, Leif ; Newman, Anne ; Nielson, Carrie M ; O'Connell, Jeffrey R ; Oostra, Ben A ; Orwoll, Eric S ; Palotie, Aarno ; Parker, Stephan ; Peacock, Munro ; Perola, Markus ; Peters, Annette ; Polasek, Ozren ; Prince, Richard L ; Räikkönen, Katri ; Ralston, Stuart H ; Ripatti, Samuli ; Robbins, John A ; Rotter, Jerome I ; Rudan, Igor ; Salomaa, Veikko ; Satterfield, Suzanne ; Schadt, Eric E ; Schipf, Sabine ; Scott, Laura ; Sehmi, Joban ; Shen, Jian ; Soo Shin, Chan ; Sigurdsson, Gunnar ; Smith, Shad ; Soranzo, Nicole ; Stančáková, Alena ; Steinhagen-Thiessen, Elisabeth ; Streeten, Elizabeth A ; Styrkarsdottir, Unnur ; Swart, Karin M A ; Tan, Sian-Tsung ; Tarnopolsky, Mark A ; Thompson, Patricia ; Thomson, Cynthia A ; Thorsteinsdottir, Unnur ; Tikkanen, Emmi ; Tranah, Gregory J ; Tuomilehto, Jaakko ; van Schoor, Natasja M ; Verma, Arjun ; Vollenweider, Peter ; Völzke, Henry ; Wactawski-Wende, Jean ; Walker, Mark ; Weedon, Michael N ; Welch, Ryan ; Wichmann, H-Erich ; Widen, Elisabeth ; Williams, Frances M K ; Wilson, James F ; Wright, Nicole C ; Xie, Weijia ; Yu, Lei ; Zhou, Yanhua ; Chambers, John C ; Döring, Angela ; van Duijn, Cornelia M ; Econs, Michael J ; Gudnason, Vilmundur ; Kooner, Jaspal S ; Psaty, Bruce M ; Spector, Timothy D ; Stefansson, Kari ; Rivadeneira, Fernando ; Uitterlinden, André G ; Wareham, Nicholas J ; Ossowski, Vicky ; Waterworth, Dawn ; Loos, Ruth J F ; Karasik, David ; Harris, Tamara B ; Ohlsson, Claes ; Kiel, Douglas P. / Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. In: Nature Communications. 2017 ; Vol. 8.
Bibtex
@article{cda94f9e148a495c94e504b7988b10a4,
title = "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass",
abstract = "Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.",
keywords = "Journal Article",
author = "Zillikens, {M Carola} and Serkalem Demissie and Yi-Hsiang Hsu and Yerges-Armstrong, {Laura M} and Wen-Chi Chou and Lisette Stolk and Gregory Livshits and Linda Broer and Toby Johnson and Koller, {Daniel L} and Zolt{\'a}n Kutalik and Jian'an Luan and Ida Malkin and Ried, {Janina S} and Smith, {Albert V} and Gudmar Thorleifsson and Liesbeth Vandenput and {Hua Zhao}, Jing and Weihua Zhang and Ali Aghdassi and Kristina {\AA}kesson and Najaf Amin and Baier, {Leslie J} and In{\^e}s Barroso and Bennett, {David A} and Lars Bertram and Rainer Biffar and Murielle Bochud and Michael Boehnke and Borecki, {Ingrid B} and Buchman, {Aron S} and Liisa Byberg and Harry Campbell and {Campos Obanda}, Natalia and Cauley, {Jane A} and Cawthon, {Peggy M} and Henna Cederberg and Zhao Chen and Cho, {Nam H} and {Jin Choi}, Hyung and Melina Claussnitzer and Francis Collins and Cummings, {Steven R} and {De Jager}, {Philip L} and Ilja Demuth and Dhonukshe-Rutten, {Rosalie A M} and Luda Diatchenko and Gudny Eiriksdottir and Enneman, {Anke W} and Mike Erdos and Eriksson, {Johan G} and Joel Eriksson and Karol Estrada and Evans, {Daniel S} and Feitosa, {Mary F} and Mao Fu and Melissa Garcia and Christian Gieger and Thomas Girke and Glazer, {Nicole L} and Harald Grallert and Jagvir Grewal and Bok-Ghee Han and Hanson, {Robert L} and Caroline Hayward and Albert Hofman and Hoffman, {Eric P} and Georg Homuth and Wen-Chi Hsueh and Hubal, {Monica J} and Alan Hubbard and Huffman, {Kim M} and Husted, {Lise B} and Thomas Illig and Erik Ingelsson and Till Ittermann and John-Olov Jansson and Jordan, {Joanne M} and Antti Jula and Magnus Karlsson and Kay-Tee Khaw and Kilpel{\"a}inen, {Tuomas O} and Norman Klopp and Kloth, {Jacqueline S L} and Koistinen, {Heikki A} and Kraus, {William E} and Stephen Kritchevsky and Teemu Kuulasmaa and Johanna Kuusisto and Markku Laakso and Jari Lahti and Thomas Lang and Langdahl, {Bente L} and Launer, {Lenore J} and Jong-Young Lee and Lerch, {Markus M} and Lewis, {Joshua R} and Lars Lind and Cecilia Lindgren and Yongmei Liu and Tian Liu and Youfang Liu and {\"O}sten Ljunggren and Mattias Lorentzon and Luben, {Robert N} and William Maixner and McGuigan, {Fiona E} and Carolina Medina-Gomez and Thomas Meitinger and H{\aa}kan Melhus and Dan Mellstr{\"o}m and Simon Melov and Karl Micha{\"e}lsson and Mitchell, {Braxton D} and Morris, {Andrew P} and Leif Mosekilde and Anne Newman and Nielson, {Carrie M} and O'Connell, {Jeffrey R} and Oostra, {Ben A} and Orwoll, {Eric S} and Aarno Palotie and Stephan Parker and Munro Peacock and Markus Perola and Annette Peters and Ozren Polasek and Prince, {Richard L} and Katri R{\"a}ikk{\"o}nen and Ralston, {Stuart H} and Samuli Ripatti and Robbins, {John A} and Rotter, {Jerome I} and Igor Rudan and Veikko Salomaa and Suzanne Satterfield and Schadt, {Eric E} and Sabine Schipf and Laura Scott and Joban Sehmi and Jian Shen and {Soo Shin}, Chan and Gunnar Sigurdsson and Shad Smith and Nicole Soranzo and Alena Stan{\v c}{\'a}kov{\'a} and Elisabeth Steinhagen-Thiessen and Streeten, {Elizabeth A} and Unnur Styrkarsdottir and Swart, {Karin M A} and Sian-Tsung Tan and Tarnopolsky, {Mark A} and Patricia Thompson and Thomson, {Cynthia A} and Unnur Thorsteinsdottir and Emmi Tikkanen and Tranah, {Gregory J} and Jaakko Tuomilehto and {van Schoor}, {Natasja M} and Arjun Verma and Peter Vollenweider and Henry V{\"o}lzke and Jean Wactawski-Wende and Mark Walker and Weedon, {Michael N} and Ryan Welch and H-Erich Wichmann and Elisabeth Widen and Williams, {Frances M K} and Wilson, {James F} and Wright, {Nicole C} and Weijia Xie and Lei Yu and Yanhua Zhou and Chambers, {John C} and Angela D{\"o}ring and {van Duijn}, {Cornelia M} and Econs, {Michael J} and Vilmundur Gudnason and Kooner, {Jaspal S} and Psaty, {Bruce M} and Spector, {Timothy D} and Kari Stefansson and Fernando Rivadeneira and Uitterlinden, {Andr{\'e} G} and Wareham, {Nicholas J} and Vicky Ossowski and Dawn Waterworth and Loos, {Ruth J F} and David Karasik and Harris, {Tamara B} and Claes Ohlsson and Kiel, {Douglas P}",
year = "2017",
month = jul,
day = "19",
doi = "10.1038/s41467-017-00031-7",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
AU - Zillikens, M Carola
AU - Demissie, Serkalem
AU - Hsu, Yi-Hsiang
AU - Yerges-Armstrong, Laura M
AU - Chou, Wen-Chi
AU - Stolk, Lisette
AU - Livshits, Gregory
AU - Broer, Linda
AU - Johnson, Toby
AU - Koller, Daniel L
AU - Kutalik, Zoltán
AU - Luan, Jian'an
AU - Malkin, Ida
AU - Ried, Janina S
AU - Smith, Albert V
AU - Thorleifsson, Gudmar
AU - Vandenput, Liesbeth
AU - Hua Zhao, Jing
AU - Zhang, Weihua
AU - Aghdassi, Ali
AU - Åkesson, Kristina
AU - Amin, Najaf
AU - Baier, Leslie J
AU - Barroso, Inês
AU - Bennett, David A
AU - Bertram, Lars
AU - Biffar, Rainer
AU - Bochud, Murielle
AU - Boehnke, Michael
AU - Borecki, Ingrid B
AU - Buchman, Aron S
AU - Byberg, Liisa
AU - Campbell, Harry
AU - Campos Obanda, Natalia
AU - Cauley, Jane A
AU - Cawthon, Peggy M
AU - Cederberg, Henna
AU - Chen, Zhao
AU - Cho, Nam H
AU - Jin Choi, Hyung
AU - Claussnitzer, Melina
AU - Collins, Francis
AU - Cummings, Steven R
AU - De Jager, Philip L
AU - Demuth, Ilja
AU - Dhonukshe-Rutten, Rosalie A M
AU - Diatchenko, Luda
AU - Eiriksdottir, Gudny
AU - Enneman, Anke W
AU - Erdos, Mike
AU - Eriksson, Johan G
AU - Eriksson, Joel
AU - Estrada, Karol
AU - Evans, Daniel S
AU - Feitosa, Mary F
AU - Fu, Mao
AU - Garcia, Melissa
AU - Gieger, Christian
AU - Girke, Thomas
AU - Glazer, Nicole L
AU - Grallert, Harald
AU - Grewal, Jagvir
AU - Han, Bok-Ghee
AU - Hanson, Robert L
AU - Hayward, Caroline
AU - Hofman, Albert
AU - Hoffman, Eric P
AU - Homuth, Georg
AU - Hsueh, Wen-Chi
AU - Hubal, Monica J
AU - Hubbard, Alan
AU - Huffman, Kim M
AU - Husted, Lise B
AU - Illig, Thomas
AU - Ingelsson, Erik
AU - Ittermann, Till
AU - Jansson, John-Olov
AU - Jordan, Joanne M
AU - Jula, Antti
AU - Karlsson, Magnus
AU - Khaw, Kay-Tee
AU - Kilpeläinen, Tuomas O
AU - Klopp, Norman
AU - Kloth, Jacqueline S L
AU - Koistinen, Heikki A
AU - Kraus, William E
AU - Kritchevsky, Stephen
AU - Kuulasmaa, Teemu
AU - Kuusisto, Johanna
AU - Laakso, Markku
AU - Lahti, Jari
AU - Lang, Thomas
AU - Langdahl, Bente L
AU - Launer, Lenore J
AU - Lee, Jong-Young
AU - Lerch, Markus M
AU - Lewis, Joshua R
AU - Lind, Lars
AU - Lindgren, Cecilia
AU - Liu, Yongmei
AU - Liu, Tian
AU - Liu, Youfang
AU - Ljunggren, Östen
AU - Lorentzon, Mattias
AU - Luben, Robert N
AU - Maixner, William
AU - McGuigan, Fiona E
AU - Medina-Gomez, Carolina
AU - Meitinger, Thomas
AU - Melhus, Håkan
AU - Mellström, Dan
AU - Melov, Simon
AU - Michaëlsson, Karl
AU - Mitchell, Braxton D
AU - Morris, Andrew P
AU - Mosekilde, Leif
AU - Newman, Anne
AU - Nielson, Carrie M
AU - O'Connell, Jeffrey R
AU - Oostra, Ben A
AU - Orwoll, Eric S
AU - Palotie, Aarno
AU - Parker, Stephan
AU - Peacock, Munro
AU - Perola, Markus
AU - Peters, Annette
AU - Polasek, Ozren
AU - Prince, Richard L
AU - Räikkönen, Katri
AU - Ralston, Stuart H
AU - Ripatti, Samuli
AU - Robbins, John A
AU - Rotter, Jerome I
AU - Rudan, Igor
AU - Salomaa, Veikko
AU - Satterfield, Suzanne
AU - Schadt, Eric E
AU - Schipf, Sabine
AU - Scott, Laura
AU - Sehmi, Joban
AU - Shen, Jian
AU - Soo Shin, Chan
AU - Sigurdsson, Gunnar
AU - Smith, Shad
AU - Soranzo, Nicole
AU - Stančáková, Alena
AU - Steinhagen-Thiessen, Elisabeth
AU - Streeten, Elizabeth A
AU - Styrkarsdottir, Unnur
AU - Swart, Karin M A
AU - Tan, Sian-Tsung
AU - Tarnopolsky, Mark A
AU - Thompson, Patricia
AU - Thomson, Cynthia A
AU - Thorsteinsdottir, Unnur
AU - Tikkanen, Emmi
AU - Tranah, Gregory J
AU - Tuomilehto, Jaakko
AU - van Schoor, Natasja M
AU - Verma, Arjun
AU - Vollenweider, Peter
AU - Völzke, Henry
AU - Wactawski-Wende, Jean
AU - Walker, Mark
AU - Weedon, Michael N
AU - Welch, Ryan
AU - Wichmann, H-Erich
AU - Widen, Elisabeth
AU - Williams, Frances M K
AU - Wilson, James F
AU - Wright, Nicole C
AU - Xie, Weijia
AU - Yu, Lei
AU - Zhou, Yanhua
AU - Chambers, John C
AU - Döring, Angela
AU - van Duijn, Cornelia M
AU - Econs, Michael J
AU - Gudnason, Vilmundur
AU - Kooner, Jaspal S
AU - Psaty, Bruce M
AU - Spector, Timothy D
AU - Stefansson, Kari
AU - Rivadeneira, Fernando
AU - Uitterlinden, André G
AU - Wareham, Nicholas J
AU - Ossowski, Vicky
AU - Waterworth, Dawn
AU - Loos, Ruth J F
AU - Karasik, David
AU - Harris, Tamara B
AU - Ohlsson, Claes
AU - Kiel, Douglas P
PY - 2017/7/19
Y1 - 2017/7/19
N2 - Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
AB - Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
KW - Journal Article
UR - https://www.nature.com/articles/s41467-017-01008-2
U2 - 10.1038/s41467-017-00031-7
DO - 10.1038/s41467-017-00031-7
M3 - Journal article
C2 - 28724990
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 80
ER -
