Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

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Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. / Frithioff-Bojsoe, Christine; Lund, Morten A. V.; Lausten-Thomsen, Ulrik; Hedley, Paula L.; Pedersen, Oluf; Christiansen, Michael; Baker, Jennifer L.; Hansen, Torben; Holm, Jens-Christian.

In: Pediatric Diabetes, Vol. 21, No. 2, 2020, p. 194-202.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Frithioff-Bojsoe, C, Lund, MAV, Lausten-Thomsen, U, Hedley, PL, Pedersen, O, Christiansen, M, Baker, JL, Hansen, T & Holm, J-C 2020, 'Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity', Pediatric Diabetes, vol. 21, no. 2, pp. 194-202. https://doi.org/10.1111/pedi.12964

APA

Frithioff-Bojsoe, C., Lund, M. A. V., Lausten-Thomsen, U., Hedley, P. L., Pedersen, O., Christiansen, M., Baker, J. L., Hansen, T., & Holm, J-C. (2020). Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. Pediatric Diabetes, 21(2), 194-202. https://doi.org/10.1111/pedi.12964

Vancouver

Frithioff-Bojsoe C, Lund MAV, Lausten-Thomsen U, Hedley PL, Pedersen O, Christiansen M et al. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. Pediatric Diabetes. 2020;21(2):194-202. https://doi.org/10.1111/pedi.12964

Author

Frithioff-Bojsoe, Christine ; Lund, Morten A. V. ; Lausten-Thomsen, Ulrik ; Hedley, Paula L. ; Pedersen, Oluf ; Christiansen, Michael ; Baker, Jennifer L. ; Hansen, Torben ; Holm, Jens-Christian. / Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. In: Pediatric Diabetes. 2020 ; Vol. 21, No. 2. pp. 194-202.

Bibtex

@article{e27f8fd49d76490ba4b3c14958bf7afd,
title = "Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity",
abstract = "Background It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin and adiponectin are both involved in fat mass regulation and the development of obesity-related disorders; furthermore, their ratio (leptin/adiponectin ratio) is suggested to be associated with insulin resistance and cardiometabolic risk. Objective To evaluate associations between fasting serum concentrations of the adipokines (total leptin and adiponectin as well as the L/A ratio) and cardiometabolic comorbidities in children with overweight/obesity. Methods A total of 2258 children with overweight/obesity or normal weight aged 6 to 18 years were studied. Differences in anthropometrics and adipokine concentrations were tested using Wilcoxon rank-sum test. Associations between the adipokines and cardiometabolic risk were tested using Spearman's correlation and logistic regression, adjusted for age and body mass index SD score (BMI-SDS). Results Compared to normal weight children; children with overweight/obesity exhibited higher leptin concentrations, lower adiponectin concentrations, and higher L/A ratios. After adjusting for age and degree of obesity, girls with overweight/obesity in the upper quartile range for the L/A ratio, when compared with girls in the lower quartile range, were more likely to have insulin resistance (odds ratio [OR]: 7.78 [95% confidence interval [CI], 3.78-16.65]), dysglycemia (OR: 3.08 [95% CI, 1.35-7.31]), and dyslipidemia (OR: 2.53 [95% CI, 1.18-5.59]); while boys were more likely to have insulin resistance (OR: 4.45 [95% CI, 2.03-10.10]). Conclusions Independent of the degree of obesity, leptin, adiponectin, and the L/A ratio were associated with insulin resistance and other cardiometabolic comorbidities in children with overweight/obesity, but the L/A ratio exhibited stronger associations than the respective adipokines.",
keywords = "adiponectin, biomarkers, insulin resistance, leptin, pediatric obesity",
author = "Christine Frithioff-Bojsoe and Lund, {Morten A. V.} and Ulrik Lausten-Thomsen and Hedley, {Paula L.} and Oluf Pedersen and Michael Christiansen and Baker, {Jennifer L.} and Torben Hansen and Jens-Christian Holm",
year = "2020",
doi = "10.1111/pedi.12964",
language = "English",
volume = "21",
pages = "194--202",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

AU - Frithioff-Bojsoe, Christine

AU - Lund, Morten A. V.

AU - Lausten-Thomsen, Ulrik

AU - Hedley, Paula L.

AU - Pedersen, Oluf

AU - Christiansen, Michael

AU - Baker, Jennifer L.

AU - Hansen, Torben

AU - Holm, Jens-Christian

PY - 2020

Y1 - 2020

N2 - Background It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin and adiponectin are both involved in fat mass regulation and the development of obesity-related disorders; furthermore, their ratio (leptin/adiponectin ratio) is suggested to be associated with insulin resistance and cardiometabolic risk. Objective To evaluate associations between fasting serum concentrations of the adipokines (total leptin and adiponectin as well as the L/A ratio) and cardiometabolic comorbidities in children with overweight/obesity. Methods A total of 2258 children with overweight/obesity or normal weight aged 6 to 18 years were studied. Differences in anthropometrics and adipokine concentrations were tested using Wilcoxon rank-sum test. Associations between the adipokines and cardiometabolic risk were tested using Spearman's correlation and logistic regression, adjusted for age and body mass index SD score (BMI-SDS). Results Compared to normal weight children; children with overweight/obesity exhibited higher leptin concentrations, lower adiponectin concentrations, and higher L/A ratios. After adjusting for age and degree of obesity, girls with overweight/obesity in the upper quartile range for the L/A ratio, when compared with girls in the lower quartile range, were more likely to have insulin resistance (odds ratio [OR]: 7.78 [95% confidence interval [CI], 3.78-16.65]), dysglycemia (OR: 3.08 [95% CI, 1.35-7.31]), and dyslipidemia (OR: 2.53 [95% CI, 1.18-5.59]); while boys were more likely to have insulin resistance (OR: 4.45 [95% CI, 2.03-10.10]). Conclusions Independent of the degree of obesity, leptin, adiponectin, and the L/A ratio were associated with insulin resistance and other cardiometabolic comorbidities in children with overweight/obesity, but the L/A ratio exhibited stronger associations than the respective adipokines.

AB - Background It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin and adiponectin are both involved in fat mass regulation and the development of obesity-related disorders; furthermore, their ratio (leptin/adiponectin ratio) is suggested to be associated with insulin resistance and cardiometabolic risk. Objective To evaluate associations between fasting serum concentrations of the adipokines (total leptin and adiponectin as well as the L/A ratio) and cardiometabolic comorbidities in children with overweight/obesity. Methods A total of 2258 children with overweight/obesity or normal weight aged 6 to 18 years were studied. Differences in anthropometrics and adipokine concentrations were tested using Wilcoxon rank-sum test. Associations between the adipokines and cardiometabolic risk were tested using Spearman's correlation and logistic regression, adjusted for age and body mass index SD score (BMI-SDS). Results Compared to normal weight children; children with overweight/obesity exhibited higher leptin concentrations, lower adiponectin concentrations, and higher L/A ratios. After adjusting for age and degree of obesity, girls with overweight/obesity in the upper quartile range for the L/A ratio, when compared with girls in the lower quartile range, were more likely to have insulin resistance (odds ratio [OR]: 7.78 [95% confidence interval [CI], 3.78-16.65]), dysglycemia (OR: 3.08 [95% CI, 1.35-7.31]), and dyslipidemia (OR: 2.53 [95% CI, 1.18-5.59]); while boys were more likely to have insulin resistance (OR: 4.45 [95% CI, 2.03-10.10]). Conclusions Independent of the degree of obesity, leptin, adiponectin, and the L/A ratio were associated with insulin resistance and other cardiometabolic comorbidities in children with overweight/obesity, but the L/A ratio exhibited stronger associations than the respective adipokines.

KW - adiponectin

KW - biomarkers

KW - insulin resistance

KW - leptin

KW - pediatric obesity

U2 - 10.1111/pedi.12964

DO - 10.1111/pedi.12964

M3 - Journal article

C2 - 31845423

VL - 21

SP - 194

EP - 202

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 2

ER -

ID: 233585239