Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice. / Zhang, Xue Song; Yin, Yue Sandra; Wang, Jincheng; Battaglia, Thomas; Krautkramer, Kimberly; Li, Wei Vivian; Li, Jackie; Brown, Mark; Zhang, Meifan; Badri, Michelle H.; Armstrong, Abigail J.S.; Strauch, Christopher M.; Wang, Zeneng; Nemet, Ina; Altomare, Nicole; Devlin, Joseph C.; He, Linchen; Morton, Jamie T.; Chalk, John Alex; Needles, Kelly; Liao, Viviane; Mount, Julia; Li, Huilin; Ruggles, Kelly V.; Bonneau, Richard A.; Dominguez-Bello, Maria Gloria; Bäckhed, Fredrik; Hazen, Stanley L.; Blaser, Martin J.

In: Cell Host and Microbe, Vol. 29, No. 8, 2021, p. 1249-1265.e9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, XS, Yin, YS, Wang, J, Battaglia, T, Krautkramer, K, Li, WV, Li, J, Brown, M, Zhang, M, Badri, MH, Armstrong, AJS, Strauch, CM, Wang, Z, Nemet, I, Altomare, N, Devlin, JC, He, L, Morton, JT, Chalk, JA, Needles, K, Liao, V, Mount, J, Li, H, Ruggles, KV, Bonneau, RA, Dominguez-Bello, MG, Bäckhed, F, Hazen, SL & Blaser, MJ 2021, 'Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice', Cell Host and Microbe, vol. 29, no. 8, pp. 1249-1265.e9. https://doi.org/10.1016/j.chom.2021.06.014

APA

Zhang, X. S., Yin, Y. S., Wang, J., Battaglia, T., Krautkramer, K., Li, W. V., Li, J., Brown, M., Zhang, M., Badri, M. H., Armstrong, A. J. S., Strauch, C. M., Wang, Z., Nemet, I., Altomare, N., Devlin, J. C., He, L., Morton, J. T., Chalk, J. A., ... Blaser, M. J. (2021). Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice. Cell Host and Microbe, 29(8), 1249-1265.e9. https://doi.org/10.1016/j.chom.2021.06.014

Vancouver

Zhang XS, Yin YS, Wang J, Battaglia T, Krautkramer K, Li WV et al. Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice. Cell Host and Microbe. 2021;29(8):1249-1265.e9. https://doi.org/10.1016/j.chom.2021.06.014

Author

Zhang, Xue Song ; Yin, Yue Sandra ; Wang, Jincheng ; Battaglia, Thomas ; Krautkramer, Kimberly ; Li, Wei Vivian ; Li, Jackie ; Brown, Mark ; Zhang, Meifan ; Badri, Michelle H. ; Armstrong, Abigail J.S. ; Strauch, Christopher M. ; Wang, Zeneng ; Nemet, Ina ; Altomare, Nicole ; Devlin, Joseph C. ; He, Linchen ; Morton, Jamie T. ; Chalk, John Alex ; Needles, Kelly ; Liao, Viviane ; Mount, Julia ; Li, Huilin ; Ruggles, Kelly V. ; Bonneau, Richard A. ; Dominguez-Bello, Maria Gloria ; Bäckhed, Fredrik ; Hazen, Stanley L. ; Blaser, Martin J. / Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice. In: Cell Host and Microbe. 2021 ; Vol. 29, No. 8. pp. 1249-1265.e9.

Bibtex

@article{1df7131f05be4e0aaa409b4c13755f85,
title = "Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice",
abstract = "Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury.",
keywords = "animal models, autoimmune, cecal material transfer, gene expression, histone modification, innate immune, microbiome, microRNA, NOD mice, type 1 diabetes",
author = "Zhang, {Xue Song} and Yin, {Yue Sandra} and Jincheng Wang and Thomas Battaglia and Kimberly Krautkramer and Li, {Wei Vivian} and Jackie Li and Mark Brown and Meifan Zhang and Badri, {Michelle H.} and Armstrong, {Abigail J.S.} and Strauch, {Christopher M.} and Zeneng Wang and Ina Nemet and Nicole Altomare and Devlin, {Joseph C.} and Linchen He and Morton, {Jamie T.} and Chalk, {John Alex} and Kelly Needles and Viviane Liao and Julia Mount and Huilin Li and Ruggles, {Kelly V.} and Bonneau, {Richard A.} and Dominguez-Bello, {Maria Gloria} and Fredrik B{\"a}ckhed and Hazen, {Stanley L.} and Blaser, {Martin J.}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
doi = "10.1016/j.chom.2021.06.014",
language = "English",
volume = "29",
pages = "1249--1265.e9",
journal = "Cell Host & Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "8",

}

RIS

TY - JOUR

T1 - Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice

AU - Zhang, Xue Song

AU - Yin, Yue Sandra

AU - Wang, Jincheng

AU - Battaglia, Thomas

AU - Krautkramer, Kimberly

AU - Li, Wei Vivian

AU - Li, Jackie

AU - Brown, Mark

AU - Zhang, Meifan

AU - Badri, Michelle H.

AU - Armstrong, Abigail J.S.

AU - Strauch, Christopher M.

AU - Wang, Zeneng

AU - Nemet, Ina

AU - Altomare, Nicole

AU - Devlin, Joseph C.

AU - He, Linchen

AU - Morton, Jamie T.

AU - Chalk, John Alex

AU - Needles, Kelly

AU - Liao, Viviane

AU - Mount, Julia

AU - Li, Huilin

AU - Ruggles, Kelly V.

AU - Bonneau, Richard A.

AU - Dominguez-Bello, Maria Gloria

AU - Bäckhed, Fredrik

AU - Hazen, Stanley L.

AU - Blaser, Martin J.

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021

Y1 - 2021

N2 - Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury.

AB - Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury.

KW - animal models

KW - autoimmune

KW - cecal material transfer

KW - gene expression

KW - histone modification

KW - innate immune

KW - microbiome

KW - microRNA

KW - NOD mice

KW - type 1 diabetes

U2 - 10.1016/j.chom.2021.06.014

DO - 10.1016/j.chom.2021.06.014

M3 - Journal article

C2 - 34289377

AN - SCOPUS:85112011795

VL - 29

SP - 1249-1265.e9

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 8

ER -

ID: 276952280