Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis
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Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis. / De Vadder, Filipe; Kovatcheva-Datchary, Petia; Zitoun, Carine; Duchampt, Adeline; Bäckhed, Gert Fredrik; Mithieux, Gilles.
In: Cell Metabolism, Vol. 24, No. 1, 12.07.2016, p. 151-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis
AU - De Vadder, Filipe
AU - Kovatcheva-Datchary, Petia
AU - Zitoun, Carine
AU - Duchampt, Adeline
AU - Bäckhed, Gert Fredrik
AU - Mithieux, Gilles
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/7/12
Y1 - 2016/7/12
N2 - Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
AB - Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
KW - Journal Article
U2 - 10.1016/j.cmet.2016.06.013
DO - 10.1016/j.cmet.2016.06.013
M3 - Journal article
C2 - 27411015
VL - 24
SP - 151
EP - 157
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 1
ER -
ID: 166682234