TY - JOUR

T1 - Nonalcoholic Fatty Liver Disease and Cardiovascular Disease

T2 - Overlapping Mechanisms

AU - Møller, Søren

AU - Kimer, Nina

AU - Kronborg, Thit

AU - Grandt, Josephine

AU - Hove, Jens Dahlgaard

AU - Barlose, Mads

AU - Gluud, Lise Lotte

N1 - Publisher Copyright: © 2021 Georg Thieme Verlag. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: Nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. NAFLD is associated with obesity, type 2 diabetes, and the metabolic syndrome and represents a considerable and increasing health burden. In the near future, NAFLD cirrhosis is expected to be the most common cause for liver transplantation. NAFLD patients have an increased risk of developing cardiovascular disease as well as liver-related morbidity. In addition, hepatic steatosis itself appears to represent an independent cardiovascular risk factor. In the present review, we provide an overview of the overlapping mechanisms and prevalence of NAFLD and cardiovascular disease.

AB - Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: Nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. NAFLD is associated with obesity, type 2 diabetes, and the metabolic syndrome and represents a considerable and increasing health burden. In the near future, NAFLD cirrhosis is expected to be the most common cause for liver transplantation. NAFLD patients have an increased risk of developing cardiovascular disease as well as liver-related morbidity. In addition, hepatic steatosis itself appears to represent an independent cardiovascular risk factor. In the present review, we provide an overview of the overlapping mechanisms and prevalence of NAFLD and cardiovascular disease.

KW - atherosclerosis

KW - chronic liver diseases

KW - cirrhosis

KW - coronary artery disease

KW - diabetes

KW - nonalcoholic steatohepatitis

KW - obesity

U2 - 10.1055/s-0041-1725022

DO - 10.1055/s-0041-1725022

M3 - Journal article

C2 - 33992031

AN - SCOPUS:85106496991

VL - 41

SP - 235

EP - 247

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 03

ER -