Parsing the Potential Neuroendocrine Actions of FGF21 in Primates

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Parsing the Potential Neuroendocrine Actions of FGF21 in Primates. / Gillum, Matthew P.

In: Endocrinology, Vol. 159, No. 5, 2018, p. 1966-1970.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gillum, MP 2018, 'Parsing the Potential Neuroendocrine Actions of FGF21 in Primates', Endocrinology, vol. 159, no. 5, pp. 1966-1970. https://doi.org/10.1210/en.2018-00208

APA

Gillum, M. P. (2018). Parsing the Potential Neuroendocrine Actions of FGF21 in Primates. Endocrinology, 159(5), 1966-1970. https://doi.org/10.1210/en.2018-00208

Vancouver

Gillum MP. Parsing the Potential Neuroendocrine Actions of FGF21 in Primates. Endocrinology. 2018;159(5):1966-1970. https://doi.org/10.1210/en.2018-00208

Author

Gillum, Matthew P. / Parsing the Potential Neuroendocrine Actions of FGF21 in Primates. In: Endocrinology. 2018 ; Vol. 159, No. 5. pp. 1966-1970.

Bibtex

@article{ec709652e53744a7ac2a4c5d73eb14dc,
title = "Parsing the Potential Neuroendocrine Actions of FGF21 in Primates",
abstract = "Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alcohol and sugar intake and also after several days of overfeeding, suggesting another role in states of positive energy balance. Recent studies suggest that in the postingestive state, FGF21 may regulate energy intake and discourage consumption of alcohol and sugars, most likely through effector circuits in the central nervous system. FGF21 also increases fat oxidation in the liver, improves markers of insulin sensitivity, and stimulates adiponectin production. Thus, in primates, FGF21 may defend against hepatic nutrient overload by promoting adaptations that reduce ectopic lipid storage, including inhibiting sugar and alcohol appetite and promoting lipid sequestration in adipose tissue.",
author = "Gillum, {Matthew P.}",
year = "2018",
doi = "10.1210/en.2018-00208",
language = "English",
volume = "159",
pages = "1966--1970",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0013-7227",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Parsing the Potential Neuroendocrine Actions of FGF21 in Primates

AU - Gillum, Matthew P.

PY - 2018

Y1 - 2018

N2 - Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alcohol and sugar intake and also after several days of overfeeding, suggesting another role in states of positive energy balance. Recent studies suggest that in the postingestive state, FGF21 may regulate energy intake and discourage consumption of alcohol and sugars, most likely through effector circuits in the central nervous system. FGF21 also increases fat oxidation in the liver, improves markers of insulin sensitivity, and stimulates adiponectin production. Thus, in primates, FGF21 may defend against hepatic nutrient overload by promoting adaptations that reduce ectopic lipid storage, including inhibiting sugar and alcohol appetite and promoting lipid sequestration in adipose tissue.

AB - Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alcohol and sugar intake and also after several days of overfeeding, suggesting another role in states of positive energy balance. Recent studies suggest that in the postingestive state, FGF21 may regulate energy intake and discourage consumption of alcohol and sugars, most likely through effector circuits in the central nervous system. FGF21 also increases fat oxidation in the liver, improves markers of insulin sensitivity, and stimulates adiponectin production. Thus, in primates, FGF21 may defend against hepatic nutrient overload by promoting adaptations that reduce ectopic lipid storage, including inhibiting sugar and alcohol appetite and promoting lipid sequestration in adipose tissue.

U2 - 10.1210/en.2018-00208

DO - 10.1210/en.2018-00208

M3 - Journal article

C2 - 29608670

VL - 159

SP - 1966

EP - 1970

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0013-7227

IS - 5

ER -

ID: 209357784