Pathophysiological-based treatments of complications of cirrhosis

Research output: Contribution to journal › Review › Research › peer-review

Standard

Pathophysiological-based treatments of complications of cirrhosis. / Møller, Søren; Kimer, Nina; Barlose, Mads; Bendtsen, Flemming.

In: Scandinavian Journal of Gastroenterology, Vol. 55, No. 4, 2020, p. 383-394.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Møller, S, Kimer, N, Barlose, M & Bendtsen, F 2020, 'Pathophysiological-based treatments of complications of cirrhosis', Scandinavian Journal of Gastroenterology, vol. 55, no. 4, pp. 383-394. https://doi.org/10.1080/00365521.2020.1744709

APA

Møller, S., Kimer, N., Barlose, M., & Bendtsen, F. (2020). Pathophysiological-based treatments of complications of cirrhosis. Scandinavian Journal of Gastroenterology, 55(4), 383-394. https://doi.org/10.1080/00365521.2020.1744709

Vancouver

Møller S, Kimer N, Barlose M, Bendtsen F. Pathophysiological-based treatments of complications of cirrhosis. Scandinavian Journal of Gastroenterology. 2020;55(4):383-394. https://doi.org/10.1080/00365521.2020.1744709

Author

Møller, Søren ; Kimer, Nina ; Barlose, Mads ; Bendtsen, Flemming. / Pathophysiological-based treatments of complications of cirrhosis. In: Scandinavian Journal of Gastroenterology. 2020 ; Vol. 55, No. 4. pp. 383-394.

Bibtex

@article{fed6c3a503704626bc46fc1b191da0c1,
title = "Pathophysiological-based treatments of complications of cirrhosis",
abstract = "Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.",
keywords = "Portal hypertension, ascites, oesophageal varices, hyperdynamic circulation, hepatorenal syndrome, hepatopulmonary syndrome, NITRIC-OXIDE SYNTHASE, PORTAL-HYPERTENSION RELATION, HEPATIC STELLATE CELLS, ARGININE METHYL-ESTER, CHRONIC LIVER-FAILURE, NECROSIS-FACTOR-ALPHA, PORTOPULMONARY HYPERTENSION, HEPATOPULMONARY SYNDROME, BETA-BLOCKERS, HYPERDYNAMIC CIRCULATION",
author = "S{\o}ren M{\o}ller and Nina Kimer and Mads Barlose and Flemming Bendtsen",
year = "2020",
doi = "10.1080/00365521.2020.1744709",
language = "English",
volume = "55",
pages = "383--394",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Pathophysiological-based treatments of complications of cirrhosis

AU - Møller, Søren

AU - Kimer, Nina

AU - Barlose, Mads

AU - Bendtsen, Flemming

PY - 2020

Y1 - 2020

N2 - Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

AB - Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

KW - Portal hypertension

KW - ascites

KW - oesophageal varices

KW - hyperdynamic circulation

KW - hepatorenal syndrome

KW - hepatopulmonary syndrome

KW - NITRIC-OXIDE SYNTHASE

KW - PORTAL-HYPERTENSION RELATION

KW - HEPATIC STELLATE CELLS

KW - ARGININE METHYL-ESTER

KW - CHRONIC LIVER-FAILURE

KW - NECROSIS-FACTOR-ALPHA

KW - PORTOPULMONARY HYPERTENSION

KW - HEPATOPULMONARY SYNDROME

KW - BETA-BLOCKERS

KW - HYPERDYNAMIC CIRCULATION

U2 - 10.1080/00365521.2020.1744709

DO - 10.1080/00365521.2020.1744709

M3 - Review

C2 - 32233873

VL - 55

SP - 383

EP - 394

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 4

ER -

ID: 250546555