PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
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PFAS Exposures and the Human Metabolome : A Systematic Review of Epidemiological Studies. / India-Aldana, Sandra; Yao, Meizhen; Midya, Vishal; Colicino, Elena; Chatzi, Leda; Chu, Jaime; Gennings, Chris; Jones, Dean P.; Loos, Ruth J.F.; Setiawan, Veronica W.; Smith, Mathew Ryan; Walker, Ryan W.; Barupal, Dinesh; Walker, Douglas I.; Valvi, Damaskini.
In: Current Pollution Reports, Vol. 9, 2023, p. 510-568.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - PFAS Exposures and the Human Metabolome
T2 - A Systematic Review of Epidemiological Studies
AU - India-Aldana, Sandra
AU - Yao, Meizhen
AU - Midya, Vishal
AU - Colicino, Elena
AU - Chatzi, Leda
AU - Chu, Jaime
AU - Gennings, Chris
AU - Jones, Dean P.
AU - Loos, Ruth J.F.
AU - Setiawan, Veronica W.
AU - Smith, Mathew Ryan
AU - Walker, Ryan W.
AU - Barupal, Dinesh
AU - Walker, Douglas I.
AU - Valvi, Damaskini
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - Purpose of Review: There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. Recent Findings: We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics. Summary: Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.
AB - Purpose of Review: There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. Recent Findings: We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics. Summary: Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.
KW - Endocrine-disrupting chemicals
KW - Human metabolome
KW - Metabolomics
KW - PFAS
KW - Systematic review
U2 - 10.1007/s40726-023-00269-4
DO - 10.1007/s40726-023-00269-4
M3 - Review
C2 - 37753190
AN - SCOPUS:85163666017
VL - 9
SP - 510
EP - 568
JO - Current Pollution Reports
JF - Current Pollution Reports
SN - 2198-6592
ER -
ID: 360606866