Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation. / Hansen, Signe Schmidt Kjølner; Krautz, Robert; Rago, Daria; Havelund, Jesper; Stigliani, Arnaud; Færgeman, Nils J.; Prézelin, Audrey; Rivière, Julie; Couturier-Tarrade, Anne; Akimov, Vyacheslav; Blagoev, Blagoy; Elfving, Betina; Neess, Ditte; Vogel, Ulla; Khodosevich, Konstantin; Hougaard, Karin Sørig; Sandelin, Albin.

In: Nature Communications, Vol. 15, 4711, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, SSK, Krautz, R, Rago, D, Havelund, J, Stigliani, A, Færgeman, NJ, Prézelin, A, Rivière, J, Couturier-Tarrade, A, Akimov, V, Blagoev, B, Elfving, B, Neess, D, Vogel, U, Khodosevich, K, Hougaard, KS & Sandelin, A 2024, 'Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation', Nature Communications, vol. 15, 4711. https://doi.org/10.1038/s41467-024-48492-x

APA

Hansen, S. S. K., Krautz, R., Rago, D., Havelund, J., Stigliani, A., Færgeman, N. J., Prézelin, A., Rivière, J., Couturier-Tarrade, A., Akimov, V., Blagoev, B., Elfving, B., Neess, D., Vogel, U., Khodosevich, K., Hougaard, K. S., & Sandelin, A. (2024). Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation. Nature Communications, 15, [4711]. https://doi.org/10.1038/s41467-024-48492-x

Vancouver

Hansen SSK, Krautz R, Rago D, Havelund J, Stigliani A, Færgeman NJ et al. Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation. Nature Communications. 2024;15. 4711. https://doi.org/10.1038/s41467-024-48492-x

Author

Hansen, Signe Schmidt Kjølner ; Krautz, Robert ; Rago, Daria ; Havelund, Jesper ; Stigliani, Arnaud ; Færgeman, Nils J. ; Prézelin, Audrey ; Rivière, Julie ; Couturier-Tarrade, Anne ; Akimov, Vyacheslav ; Blagoev, Blagoy ; Elfving, Betina ; Neess, Ditte ; Vogel, Ulla ; Khodosevich, Konstantin ; Hougaard, Karin Sørig ; Sandelin, Albin. / Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation. In: Nature Communications. 2024 ; Vol. 15.

Bibtex

@article{bd18839a34904446af026acad2aed20f,
title = "Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation",
abstract = "The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.",
author = "Hansen, {Signe Schmidt Kj{\o}lner} and Robert Krautz and Daria Rago and Jesper Havelund and Arnaud Stigliani and F{\ae}rgeman, {Nils J.} and Audrey Pr{\'e}zelin and Julie Rivi{\`e}re and Anne Couturier-Tarrade and Vyacheslav Akimov and Blagoy Blagoev and Betina Elfving and Ditte Neess and Ulla Vogel and Konstantin Khodosevich and Hougaard, {Karin S{\o}rig} and Albin Sandelin",
note = "Publisher Copyright: {\textcopyright} 2024. The Author(s).",
year = "2024",
doi = "10.1038/s41467-024-48492-x",
language = "English",
volume = "15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

AU - Hansen, Signe Schmidt Kjølner

AU - Krautz, Robert

AU - Rago, Daria

AU - Havelund, Jesper

AU - Stigliani, Arnaud

AU - Færgeman, Nils J.

AU - Prézelin, Audrey

AU - Rivière, Julie

AU - Couturier-Tarrade, Anne

AU - Akimov, Vyacheslav

AU - Blagoev, Blagoy

AU - Elfving, Betina

AU - Neess, Ditte

AU - Vogel, Ulla

AU - Khodosevich, Konstantin

AU - Hougaard, Karin Sørig

AU - Sandelin, Albin

N1 - Publisher Copyright: © 2024. The Author(s).

PY - 2024

Y1 - 2024

N2 - The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.

AB - The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.

U2 - 10.1038/s41467-024-48492-x

DO - 10.1038/s41467-024-48492-x

M3 - Journal article

C2 - 38830841

AN - SCOPUS:85195014674

VL - 15

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 4711

ER -

ID: 394480097