Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy

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Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy. / Qian, Kui; Di Lieto, Antonio; Corander, Jukka; Auvinen, Petri; Greco, Dario.

In: Advances in Experimental Medicine and Biology, Vol. 736, 2012, p. 563-77.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Qian, K, Di Lieto, A, Corander, J, Auvinen, P & Greco, D 2012, 'Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy', Advances in Experimental Medicine and Biology, vol. 736, pp. 563-77. https://doi.org/10.1007/978-1-4419-7210-1_33

APA

Qian, K., Di Lieto, A., Corander, J., Auvinen, P., & Greco, D. (2012). Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy. Advances in Experimental Medicine and Biology, 736, 563-77. https://doi.org/10.1007/978-1-4419-7210-1_33

Vancouver

Qian K, Di Lieto A, Corander J, Auvinen P, Greco D. Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy. Advances in Experimental Medicine and Biology. 2012;736:563-77. https://doi.org/10.1007/978-1-4419-7210-1_33

Author

Qian, Kui ; Di Lieto, Antonio ; Corander, Jukka ; Auvinen, Petri ; Greco, Dario. / Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy. In: Advances in Experimental Medicine and Biology. 2012 ; Vol. 736. pp. 563-77.

Bibtex

@article{2defa9c651134ea1a152bb33125e8b49,
title = "Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy",
abstract = "The differential diagnosis of schizophrenia (SZ) and bipolar disorder (BD) is based solely on clinical features and upon a subset of overlapping symptoms. Within the last years, an increasing amount of clinical, epidemiological and genetic data suggested inconsistent with the Kraepelinian dichotomy. We performed re-analysis of genome-wide gene expression data obtained from postmortem prefrontal cortex (PEC) of both BD and SZ patients with matched controls from four independent microarray experiments. We found 2,577 and 477 genes specifically altered in BD and SZ, respectively. Of these, 164 genes were shared between the syndromes. We identified genes of the transcriptional and post-transcriptional machineries altered in BD and genes of the development changed in SZ. Our results showed that the genomic expression profile of BD and SZ had some similarity but still could be well-distinguished by suitable statistical test.",
keywords = "Bipolar Disorder, Computational Biology, Female, Gene Expression Profiling, Humans, Male, Oligonucleotide Array Sequence Analysis, Postmortem Changes, Prefrontal Cortex, Reproducibility of Results, Schizophrenia",
author = "Kui Qian and {Di Lieto}, Antonio and Jukka Corander and Petri Auvinen and Dario Greco",
year = "2012",
doi = "10.1007/978-1-4419-7210-1_33",
language = "English",
volume = "736",
pages = "563--77",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy

AU - Qian, Kui

AU - Di Lieto, Antonio

AU - Corander, Jukka

AU - Auvinen, Petri

AU - Greco, Dario

PY - 2012

Y1 - 2012

N2 - The differential diagnosis of schizophrenia (SZ) and bipolar disorder (BD) is based solely on clinical features and upon a subset of overlapping symptoms. Within the last years, an increasing amount of clinical, epidemiological and genetic data suggested inconsistent with the Kraepelinian dichotomy. We performed re-analysis of genome-wide gene expression data obtained from postmortem prefrontal cortex (PEC) of both BD and SZ patients with matched controls from four independent microarray experiments. We found 2,577 and 477 genes specifically altered in BD and SZ, respectively. Of these, 164 genes were shared between the syndromes. We identified genes of the transcriptional and post-transcriptional machineries altered in BD and genes of the development changed in SZ. Our results showed that the genomic expression profile of BD and SZ had some similarity but still could be well-distinguished by suitable statistical test.

AB - The differential diagnosis of schizophrenia (SZ) and bipolar disorder (BD) is based solely on clinical features and upon a subset of overlapping symptoms. Within the last years, an increasing amount of clinical, epidemiological and genetic data suggested inconsistent with the Kraepelinian dichotomy. We performed re-analysis of genome-wide gene expression data obtained from postmortem prefrontal cortex (PEC) of both BD and SZ patients with matched controls from four independent microarray experiments. We found 2,577 and 477 genes specifically altered in BD and SZ, respectively. Of these, 164 genes were shared between the syndromes. We identified genes of the transcriptional and post-transcriptional machineries altered in BD and genes of the development changed in SZ. Our results showed that the genomic expression profile of BD and SZ had some similarity but still could be well-distinguished by suitable statistical test.

KW - Bipolar Disorder

KW - Computational Biology

KW - Female

KW - Gene Expression Profiling

KW - Humans

KW - Male

KW - Oligonucleotide Array Sequence Analysis

KW - Postmortem Changes

KW - Prefrontal Cortex

KW - Reproducibility of Results

KW - Schizophrenia

U2 - 10.1007/978-1-4419-7210-1_33

DO - 10.1007/978-1-4419-7210-1_33

M3 - Journal article

C2 - 22161352

VL - 736

SP - 563

EP - 577

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -

ID: 95706811