Reference values for serum total adiponectin in healthy non-obese children and adolescents
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Reference values for serum total adiponectin in healthy non-obese children and adolescents. / Lausten-Thomsen, Ulrik; Christiansen, Michael; Fonvig, Cilius Esmann; Trier, Cæcilie; Pedersen, Oluf; Hansen, Torben; Holm, Jens-Christian.
In: Clinica Chimica Acta, Vol. 450, 23.10.2015, p. 11-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reference values for serum total adiponectin in healthy non-obese children and adolescents
AU - Lausten-Thomsen, Ulrik
AU - Christiansen, Michael
AU - Fonvig, Cilius Esmann
AU - Trier, Cæcilie
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Holm, Jens-Christian
N1 - Copyright © 2015. Published by Elsevier B.V.
PY - 2015/10/23
Y1 - 2015/10/23
N2 - BACKGROUND: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels.METHODS: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization.RESULTS: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p<0.0001) and boys (p=<0.0001) and for both sexes combined (p<0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y=-0.1478∗X+6.046; 2.5th percentile: Y=-0.06256∗X+2.34; 97.5th percentile: Y=-0.4086∗X+22.39, where Y=adiponectin in μg/mL and X=years of age (from 6 to 18years).CONCLUSION: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.
AB - BACKGROUND: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels.METHODS: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization.RESULTS: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p<0.0001) and boys (p=<0.0001) and for both sexes combined (p<0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y=-0.1478∗X+6.046; 2.5th percentile: Y=-0.06256∗X+2.34; 97.5th percentile: Y=-0.4086∗X+22.39, where Y=adiponectin in μg/mL and X=years of age (from 6 to 18years).CONCLUSION: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.
U2 - 10.1016/j.cca.2015.07.012
DO - 10.1016/j.cca.2015.07.012
M3 - Journal article
C2 - 26169157
VL - 450
SP - 11
EP - 14
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -
ID: 150709195