Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. / Helgason, Agnar; Pálsson, Snaebjörn; Thorleifsson, Gudmar; Grant, Struan F A; Emilsson, Valur; Gunnarsdottir, Steinunn; Adeyemo, Adebowale; Chen, Yuanxiu; Chen, Guanjie; Reynisdottir, Inga; Benediktsson, Rafn; Hinney, Anke; Hansen, Torben; Andersen, Gitte; Borch-Johnsen, Knut; Jorgensen, Torben; Schäfer, Helmut; Faruque, Mezbah; Doumatey, Ayo; Zhou, Jie; Wilensky, Robert L; Reilly, Muredach P; Rader, Daniel J; Bagger, Yu; Christiansen, Claus; Sigurdsson, Gunnar; Hebebrand, Johannes; Pedersen, Oluf; Thorsteinsdottir, Unnur; Gulcher, Jeffrey R; Kong, Augustine; Rotimi, Charles; Stefánsson, Kári.

In: Nature Genetics, Vol. 39, No. 2, 2007, p. 218-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Helgason, A, Pálsson, S, Thorleifsson, G, Grant, SFA, Emilsson, V, Gunnarsdottir, S, Adeyemo, A, Chen, Y, Chen, G, Reynisdottir, I, Benediktsson, R, Hinney, A, Hansen, T, Andersen, G, Borch-Johnsen, K, Jorgensen, T, Schäfer, H, Faruque, M, Doumatey, A, Zhou, J, Wilensky, RL, Reilly, MP, Rader, DJ, Bagger, Y, Christiansen, C, Sigurdsson, G, Hebebrand, J, Pedersen, O, Thorsteinsdottir, U, Gulcher, JR, Kong, A, Rotimi, C & Stefánsson, K 2007, 'Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution', Nature Genetics, vol. 39, no. 2, pp. 218-25. https://doi.org/10.1038/ng1960

APA

Helgason, A., Pálsson, S., Thorleifsson, G., Grant, S. F. A., Emilsson, V., Gunnarsdottir, S., Adeyemo, A., Chen, Y., Chen, G., Reynisdottir, I., Benediktsson, R., Hinney, A., Hansen, T., Andersen, G., Borch-Johnsen, K., Jorgensen, T., Schäfer, H., Faruque, M., Doumatey, A., ... Stefánsson, K. (2007). Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nature Genetics, 39(2), 218-25. https://doi.org/10.1038/ng1960

Vancouver

Helgason A, Pálsson S, Thorleifsson G, Grant SFA, Emilsson V, Gunnarsdottir S et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nature Genetics. 2007;39(2):218-25. https://doi.org/10.1038/ng1960

Author

Helgason, Agnar ; Pálsson, Snaebjörn ; Thorleifsson, Gudmar ; Grant, Struan F A ; Emilsson, Valur ; Gunnarsdottir, Steinunn ; Adeyemo, Adebowale ; Chen, Yuanxiu ; Chen, Guanjie ; Reynisdottir, Inga ; Benediktsson, Rafn ; Hinney, Anke ; Hansen, Torben ; Andersen, Gitte ; Borch-Johnsen, Knut ; Jorgensen, Torben ; Schäfer, Helmut ; Faruque, Mezbah ; Doumatey, Ayo ; Zhou, Jie ; Wilensky, Robert L ; Reilly, Muredach P ; Rader, Daniel J ; Bagger, Yu ; Christiansen, Claus ; Sigurdsson, Gunnar ; Hebebrand, Johannes ; Pedersen, Oluf ; Thorsteinsdottir, Unnur ; Gulcher, Jeffrey R ; Kong, Augustine ; Rotimi, Charles ; Stefánsson, Kári. / Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. In: Nature Genetics. 2007 ; Vol. 39, No. 2. pp. 218-25.

Bibtex

@article{ce78bd8949994ee18450d0577e9eadd7,
title = "Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution",
abstract = "We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapB(T2D), to the ancestral T allele of a SNP, rs7903146, through replication in West African and Danish type 2 diabetes case-control studies and an expanded Icelandic study. We also identify another variant of the same gene, HapA, that shows evidence of positive selection in East Asian, European and West African populations. Notably, HapA shows a suggestive association with body mass index and altered concentrations of the hunger-satiety hormones ghrelin and leptin in males, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.",
keywords = "African Continental Ancestry Group, Asian Continental Ancestry Group, Biological Evolution, Body Mass Index, Case-Control Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Haplotypes, Humans, Iceland, Male, Polymorphism, Single Nucleotide, Risk, Selection, Genetic, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein",
author = "Agnar Helgason and Snaebj{\"o}rn P{\'a}lsson and Gudmar Thorleifsson and Grant, {Struan F A} and Valur Emilsson and Steinunn Gunnarsdottir and Adebowale Adeyemo and Yuanxiu Chen and Guanjie Chen and Inga Reynisdottir and Rafn Benediktsson and Anke Hinney and Torben Hansen and Gitte Andersen and Knut Borch-Johnsen and Torben Jorgensen and Helmut Sch{\"a}fer and Mezbah Faruque and Ayo Doumatey and Jie Zhou and Wilensky, {Robert L} and Reilly, {Muredach P} and Rader, {Daniel J} and Yu Bagger and Claus Christiansen and Gunnar Sigurdsson and Johannes Hebebrand and Oluf Pedersen and Unnur Thorsteinsdottir and Gulcher, {Jeffrey R} and Augustine Kong and Charles Rotimi and K{\'a}ri Stef{\'a}nsson",
year = "2007",
doi = "10.1038/ng1960",
language = "English",
volume = "39",
pages = "218--25",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

AU - Helgason, Agnar

AU - Pálsson, Snaebjörn

AU - Thorleifsson, Gudmar

AU - Grant, Struan F A

AU - Emilsson, Valur

AU - Gunnarsdottir, Steinunn

AU - Adeyemo, Adebowale

AU - Chen, Yuanxiu

AU - Chen, Guanjie

AU - Reynisdottir, Inga

AU - Benediktsson, Rafn

AU - Hinney, Anke

AU - Hansen, Torben

AU - Andersen, Gitte

AU - Borch-Johnsen, Knut

AU - Jorgensen, Torben

AU - Schäfer, Helmut

AU - Faruque, Mezbah

AU - Doumatey, Ayo

AU - Zhou, Jie

AU - Wilensky, Robert L

AU - Reilly, Muredach P

AU - Rader, Daniel J

AU - Bagger, Yu

AU - Christiansen, Claus

AU - Sigurdsson, Gunnar

AU - Hebebrand, Johannes

AU - Pedersen, Oluf

AU - Thorsteinsdottir, Unnur

AU - Gulcher, Jeffrey R

AU - Kong, Augustine

AU - Rotimi, Charles

AU - Stefánsson, Kári

PY - 2007

Y1 - 2007

N2 - We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapB(T2D), to the ancestral T allele of a SNP, rs7903146, through replication in West African and Danish type 2 diabetes case-control studies and an expanded Icelandic study. We also identify another variant of the same gene, HapA, that shows evidence of positive selection in East Asian, European and West African populations. Notably, HapA shows a suggestive association with body mass index and altered concentrations of the hunger-satiety hormones ghrelin and leptin in males, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.

AB - We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapB(T2D), to the ancestral T allele of a SNP, rs7903146, through replication in West African and Danish type 2 diabetes case-control studies and an expanded Icelandic study. We also identify another variant of the same gene, HapA, that shows evidence of positive selection in East Asian, European and West African populations. Notably, HapA shows a suggestive association with body mass index and altered concentrations of the hunger-satiety hormones ghrelin and leptin in males, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.

KW - African Continental Ancestry Group

KW - Asian Continental Ancestry Group

KW - Biological Evolution

KW - Body Mass Index

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Haplotypes

KW - Humans

KW - Iceland

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Risk

KW - Selection, Genetic

KW - TCF Transcription Factors

KW - Transcription Factor 7-Like 2 Protein

U2 - 10.1038/ng1960

DO - 10.1038/ng1960

M3 - Journal article

C2 - 17206141

VL - 39

SP - 218

EP - 225

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

ER -

ID: 38336238