Rev-erbα and the circadian transcriptional regulation of metabolism.
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Rev-erbα and the circadian transcriptional regulation of metabolism. / Gerhart-Hines, Z.; Lazar, M. A.
In: Diabetes, Obesity and Metabolism Online, Vol. 17, No. S1, 2015, p. 12-16.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Rev-erbα and the circadian transcriptional regulation of metabolism.
AU - Gerhart-Hines, Z.
AU - Lazar, M. A.
N1 - M1 - Copyright (C) 2015 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2015:1474260(Journal; General Review; Online Computer File)
PY - 2015
Y1 - 2015
N2 - The circadian clock orchestrates the coordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiol. function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biol. networks and its relevance to organismal physiology.
AB - The circadian clock orchestrates the coordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiol. function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biol. networks and its relevance to organismal physiology.
KW - review Reverb alpha circadian rhythm metab transcriptional regulation
U2 - 10.1111/dom.12510
DO - 10.1111/dom.12510
M3 - Journal article
VL - 17
SP - 12
EP - 16
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - S1
ER -
ID: 150702520