Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity. / Castellanos-Jankiewicz, Ashley; Guzman-Quevedo, Omar; Fenelon, Valerie S.; Zizzari, Philippe; Quarta, Carmelo; Bellocchio, Luigi; Tailleux, Anne; Charton, Julie; Fernandois, Daniela; Henricsson, Marcus; Piveteau, Catherine; Simon, Vincent; Allard, Camille; Quemener, Sandrine; Guinot, Valentine; Hennuyer, Nathalie; Perino, Alessia; Duveau, Alexia; Maitre, Marlene; Leste-Lasserre, Thierry; Clark, Samantha; Dupuy, Nathalie; Cannich, Astrid; Gonzales, Delphine; Deprez, Benoit; Mithieux, Gilles; Dombrowicz, David; Backhed, Fredrik; Prevot, Vincent; Marsicano, Giovanni; Staels, Bart; Schoonjans, Kristina; Cota, Daniela.

In: Cell Metabolism, Vol. 33, No. 7, 2021, p. 1483-1492.e1-e10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Castellanos-Jankiewicz, A, Guzman-Quevedo, O, Fenelon, VS, Zizzari, P, Quarta, C, Bellocchio, L, Tailleux, A, Charton, J, Fernandois, D, Henricsson, M, Piveteau, C, Simon, V, Allard, C, Quemener, S, Guinot, V, Hennuyer, N, Perino, A, Duveau, A, Maitre, M, Leste-Lasserre, T, Clark, S, Dupuy, N, Cannich, A, Gonzales, D, Deprez, B, Mithieux, G, Dombrowicz, D, Backhed, F, Prevot, V, Marsicano, G, Staels, B, Schoonjans, K & Cota, D 2021, 'Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity', Cell Metabolism, vol. 33, no. 7, pp. 1483-1492.e1-e10. https://doi.org/10.1016/j.cmet.2021.04.009

APA

Castellanos-Jankiewicz, A., Guzman-Quevedo, O., Fenelon, V. S., Zizzari, P., Quarta, C., Bellocchio, L., Tailleux, A., Charton, J., Fernandois, D., Henricsson, M., Piveteau, C., Simon, V., Allard, C., Quemener, S., Guinot, V., Hennuyer, N., Perino, A., Duveau, A., Maitre, M., ... Cota, D. (2021). Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metabolism, 33(7), 1483-1492.e1-e10. https://doi.org/10.1016/j.cmet.2021.04.009

Vancouver

Castellanos-Jankiewicz A, Guzman-Quevedo O, Fenelon VS, Zizzari P, Quarta C, Bellocchio L et al. Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metabolism. 2021;33(7):1483-1492.e1-e10. https://doi.org/10.1016/j.cmet.2021.04.009

Author

Castellanos-Jankiewicz, Ashley ; Guzman-Quevedo, Omar ; Fenelon, Valerie S. ; Zizzari, Philippe ; Quarta, Carmelo ; Bellocchio, Luigi ; Tailleux, Anne ; Charton, Julie ; Fernandois, Daniela ; Henricsson, Marcus ; Piveteau, Catherine ; Simon, Vincent ; Allard, Camille ; Quemener, Sandrine ; Guinot, Valentine ; Hennuyer, Nathalie ; Perino, Alessia ; Duveau, Alexia ; Maitre, Marlene ; Leste-Lasserre, Thierry ; Clark, Samantha ; Dupuy, Nathalie ; Cannich, Astrid ; Gonzales, Delphine ; Deprez, Benoit ; Mithieux, Gilles ; Dombrowicz, David ; Backhed, Fredrik ; Prevot, Vincent ; Marsicano, Giovanni ; Staels, Bart ; Schoonjans, Kristina ; Cota, Daniela. / Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity. In: Cell Metabolism. 2021 ; Vol. 33, No. 7. pp. 1483-1492.e1-e10.

Bibtex

@article{fe018b5b1e4c4307abad03947b0ad236,
title = "Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity",
abstract = "Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet induced obesity.",
keywords = "ACID RECEPTOR TGR5, ENERGY-EXPENDITURE, GASTRIC BYPASS, GLUCOSE, ACTIVATION, SERUM, THERMOGENESIS, SECRETION, NEURONS, MOUSE",
author = "Ashley Castellanos-Jankiewicz and Omar Guzman-Quevedo and Fenelon, {Valerie S.} and Philippe Zizzari and Carmelo Quarta and Luigi Bellocchio and Anne Tailleux and Julie Charton and Daniela Fernandois and Marcus Henricsson and Catherine Piveteau and Vincent Simon and Camille Allard and Sandrine Quemener and Valentine Guinot and Nathalie Hennuyer and Alessia Perino and Alexia Duveau and Marlene Maitre and Thierry Leste-Lasserre and Samantha Clark and Nathalie Dupuy and Astrid Cannich and Delphine Gonzales and Benoit Deprez and Gilles Mithieux and David Dombrowicz and Fredrik Backhed and Vincent Prevot and Giovanni Marsicano and Bart Staels and Kristina Schoonjans and Daniela Cota",
year = "2021",
doi = "10.1016/j.cmet.2021.04.009",
language = "English",
volume = "33",
pages = "1483--1492.e1--e10",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

AU - Castellanos-Jankiewicz, Ashley

AU - Guzman-Quevedo, Omar

AU - Fenelon, Valerie S.

AU - Zizzari, Philippe

AU - Quarta, Carmelo

AU - Bellocchio, Luigi

AU - Tailleux, Anne

AU - Charton, Julie

AU - Fernandois, Daniela

AU - Henricsson, Marcus

AU - Piveteau, Catherine

AU - Simon, Vincent

AU - Allard, Camille

AU - Quemener, Sandrine

AU - Guinot, Valentine

AU - Hennuyer, Nathalie

AU - Perino, Alessia

AU - Duveau, Alexia

AU - Maitre, Marlene

AU - Leste-Lasserre, Thierry

AU - Clark, Samantha

AU - Dupuy, Nathalie

AU - Cannich, Astrid

AU - Gonzales, Delphine

AU - Deprez, Benoit

AU - Mithieux, Gilles

AU - Dombrowicz, David

AU - Backhed, Fredrik

AU - Prevot, Vincent

AU - Marsicano, Giovanni

AU - Staels, Bart

AU - Schoonjans, Kristina

AU - Cota, Daniela

PY - 2021

Y1 - 2021

N2 - Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet induced obesity.

AB - Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet induced obesity.

KW - ACID RECEPTOR TGR5

KW - ENERGY-EXPENDITURE

KW - GASTRIC BYPASS

KW - GLUCOSE

KW - ACTIVATION

KW - SERUM

KW - THERMOGENESIS

KW - SECRETION

KW - NEURONS

KW - MOUSE

U2 - 10.1016/j.cmet.2021.04.009

DO - 10.1016/j.cmet.2021.04.009

M3 - Journal article

C2 - 33887197

VL - 33

SP - 1483-1492.e1-e10

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 7

ER -

ID: 275484590