Signals from the gut microbiota to distant organs in physiology and disease

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Signals from the gut microbiota to distant organs in physiology and disease. / Schroeder, Bjoern O; Bäckhed, Gert Fredrik.

In: Nature Medicine, Vol. 22, No. 10, 06.10.2016, p. 1079-1089.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schroeder, BO & Bäckhed, GF 2016, 'Signals from the gut microbiota to distant organs in physiology and disease', Nature Medicine, vol. 22, no. 10, pp. 1079-1089. https://doi.org/10.1038/nm.4185

APA

Schroeder, B. O., & Bäckhed, G. F. (2016). Signals from the gut microbiota to distant organs in physiology and disease. Nature Medicine, 22(10), 1079-1089. https://doi.org/10.1038/nm.4185

Vancouver

Schroeder BO, Bäckhed GF. Signals from the gut microbiota to distant organs in physiology and disease. Nature Medicine. 2016 Oct 6;22(10):1079-1089. https://doi.org/10.1038/nm.4185

Author

Schroeder, Bjoern O ; Bäckhed, Gert Fredrik. / Signals from the gut microbiota to distant organs in physiology and disease. In: Nature Medicine. 2016 ; Vol. 22, No. 10. pp. 1079-1089.

Bibtex

@article{8696f44ab44e477d9fe233859af1e82f,
title = "Signals from the gut microbiota to distant organs in physiology and disease",
abstract = "The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.",
author = "Schroeder, {Bjoern O} and B{\"a}ckhed, {Gert Fredrik}",
year = "2016",
month = oct,
day = "6",
doi = "10.1038/nm.4185",
language = "English",
volume = "22",
pages = "1079--1089",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "nature publishing group",
number = "10",

}

RIS

TY - JOUR

T1 - Signals from the gut microbiota to distant organs in physiology and disease

AU - Schroeder, Bjoern O

AU - Bäckhed, Gert Fredrik

PY - 2016/10/6

Y1 - 2016/10/6

N2 - The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.

AB - The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.

U2 - 10.1038/nm.4185

DO - 10.1038/nm.4185

M3 - Journal article

C2 - 27711063

VL - 22

SP - 1079

EP - 1089

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 10

ER -

ID: 166941532