Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
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Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. / Sparsø, Thomas; Hussain, Meena Shaheen; Borch-Johnsen, Knut; Jørgensen, Torben; Madsbad, Sten; Hansen, Torben; Pedersen, Oluf; Andersen, Gitte.
In: Molecular Genetics and Metabolism, Vol. 92, No. 3, 2007, p. 278-282.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
AU - Sparsø, Thomas
AU - Hussain, Meena Shaheen
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Madsbad, Sten
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Andersen, Gitte
PY - 2007
Y1 - 2007
N2 - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.
AB - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.
KW - Blood Glucose
KW - Calcium-Binding Proteins
KW - Case-Control Studies
KW - Denmark
KW - Diabetes Mellitus, Type 2
KW - Dyslipidemias
KW - Ethnic Groups
KW - European Continental Ancestry Group
KW - Female
KW - Gene Frequency
KW - Genotype
KW - Glucose Tolerance Test
KW - Humans
KW - Insulin
KW - Male
KW - Middle Aged
KW - Mitochondrial Proteins
KW - Obesity
KW - Polymorphism, Single Nucleotide
U2 - 10.1016/j.ymgme.2007.06.011
DO - 10.1016/j.ymgme.2007.06.011
M3 - Journal article
C2 - 17681849
VL - 92
SP - 278
EP - 282
JO - Molecular Genetics and Metabolism
JF - Molecular Genetics and Metabolism
SN - 1096-7192
IS - 3
ER -
ID: 4042542