The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
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The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites. / Jensen, Dorit P; Andersen, Mette K; Hansen, Lars; Eiberg, Hans; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf; Andreasen, Camilla H.
In: Journal of Molecular Medicine, Vol. 85, No. 5, 2007, p. 445-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
AU - Jensen, Dorit P
AU - Andersen, Mette K
AU - Hansen, Lars
AU - Eiberg, Hans
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Andreasen, Camilla H
PY - 2007
Y1 - 2007
N2 - Food intake and weight gain are influenced by endocannabinoids whose actions are regulated by the fatty acid amide hydrolase (FAAH) enzyme. The homozygous Thr/Thr genotype of the functional Pro129Thr variant (rs324420) in the gene encoding FAAH was recently reported to associate with overweight and obesity in white and black populations. We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801). In case-control studies of obesity, a borderline association with the major Pro allele was identified; however, after correction for multiple testing, no association was found. Furthermore, a possible association between the major Pro allele and obesity was not supported by studies of obesity-related quantitative traits. In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites.
AB - Food intake and weight gain are influenced by endocannabinoids whose actions are regulated by the fatty acid amide hydrolase (FAAH) enzyme. The homozygous Thr/Thr genotype of the functional Pro129Thr variant (rs324420) in the gene encoding FAAH was recently reported to associate with overweight and obesity in white and black populations. We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801). In case-control studies of obesity, a borderline association with the major Pro allele was identified; however, after correction for multiple testing, no association was found. Furthermore, a possible association between the major Pro allele and obesity was not supported by studies of obesity-related quantitative traits. In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites.
KW - Adult
KW - Amidohydrolases
KW - Body Mass Index
KW - Case-Control Studies
KW - Cohort Studies
KW - Denmark
KW - European Continental Ancestry Group
KW - Female
KW - Gene Frequency
KW - Genotype
KW - Humans
KW - Male
KW - Middle Aged
KW - Mutation
KW - Obesity
KW - Phenotype
KW - Population Surveillance
KW - Proline
KW - Threonine
U2 - 10.1007/s00109-006-0139-0
DO - 10.1007/s00109-006-0139-0
M3 - Journal article
C2 - 17216208
VL - 85
SP - 445
EP - 449
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
SN - 0946-2716
IS - 5
ER -
ID: 4037150