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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. / Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar; Luan, Jian'an; Donnelly, Louise A; Kanoni, Stavroula; Petersen, Ann-Kristin; Pihur, Vasyl; Strawbridge, Rona J; Shungin, Dmitry; Hughes, Maria F; Meirelles, Osorio; Kaakinen, Marika; Bouatia-Naji, Nabila; Kristiansson, Kati; Shah, Sonia; Kleber, Marcus E; Guo, Xiuqing; Lyytikäinen, Leo-Pekka; Fava, Cristiano; Eriksson, Niclas; Nolte, Ilja M; Magnusson, Patrik K; Salfati, Elias L; Rallidis, Loukianos S; Theusch, Elizabeth; Smith, Andrew J P; Folkersen, Lasse; Witkowska, Kate; Pers, Tune H; Joehanes, Roby; Kim, Stuart K; Lataniotis, Lazaros; Jansen, Rick; Johnson, Andrew D; Warren, Helen; Kim, Young Jin; Zhao, Wei; Wu, Ying; Tayo, Bamidele O; Bochud, Murielle; Absher, Devin; Adair, Linda S; Amin, Najaf; Njølstad, Inger; Schwarz, Peter E H; CHARGE-EchoGen Consortium.
In:
Nature Genetics, Vol. 48, No. 10, 12.09.2016, p. 1171-1184.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Ehret, GB, Ferreira, T, Chasman, DI, Jackson, AU, Schmidt, EM, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, LA, Kanoni, S, Petersen, A-K, Pihur, V, Strawbridge, RJ, Shungin, D, Hughes, MF, Meirelles, O, Kaakinen, M, Bouatia-Naji, N, Kristiansson, K, Shah, S, Kleber, ME, Guo, X, Lyytikäinen, L-P, Fava, C, Eriksson, N, Nolte, IM, Magnusson, PK, Salfati, EL, Rallidis, LS, Theusch, E, Smith, AJP, Folkersen, L, Witkowska, K
, Pers, TH, Joehanes, R, Kim, SK, Lataniotis, L, Jansen, R, Johnson, AD, Warren, H, Kim, YJ, Zhao, W, Wu, Y, Tayo, BO, Bochud, M, Absher, D, Adair, LS, Amin, N, Njølstad, I
, Schwarz, PEH & CHARGE-EchoGen Consortium 2016, '
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals',
Nature Genetics, vol. 48, no. 10, pp. 1171-1184.
https://doi.org/10.1038/ng.3667APA
Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Petersen, A-K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., ... CHARGE-EchoGen Consortium (2016).
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nature Genetics,
48(10), 1171-1184.
https://doi.org/10.1038/ng.3667Vancouver
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T et al.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nature Genetics. 2016 Sep 12;48(10):1171-1184.
https://doi.org/10.1038/ng.3667Author
Ehret, Georg B ; Ferreira, Teresa ; Chasman, Daniel I ; Jackson, Anne U ; Schmidt, Ellen M ; Johnson, Toby ; Thorleifsson, Gudmar ; Luan, Jian'an ; Donnelly, Louise A ; Kanoni, Stavroula ; Petersen, Ann-Kristin ; Pihur, Vasyl ; Strawbridge, Rona J ; Shungin, Dmitry ; Hughes, Maria F ; Meirelles, Osorio ; Kaakinen, Marika ; Bouatia-Naji, Nabila ; Kristiansson, Kati ; Shah, Sonia ; Kleber, Marcus E ; Guo, Xiuqing ; Lyytikäinen, Leo-Pekka ; Fava, Cristiano ; Eriksson, Niclas ; Nolte, Ilja M ; Magnusson, Patrik K ; Salfati, Elias L ; Rallidis, Loukianos S ; Theusch, Elizabeth ; Smith, Andrew J P ; Folkersen, Lasse ; Witkowska, Kate ; Pers, Tune H ; Joehanes, Roby ; Kim, Stuart K ; Lataniotis, Lazaros ; Jansen, Rick ; Johnson, Andrew D ; Warren, Helen ; Kim, Young Jin ; Zhao, Wei ; Wu, Ying ; Tayo, Bamidele O ; Bochud, Murielle ; Absher, Devin ; Adair, Linda S ; Amin, Najaf ; Njølstad, Inger ; Schwarz, Peter E H ; CHARGE-EchoGen Consortium. / The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. In: Nature Genetics. 2016 ; Vol. 48, No. 10. pp. 1171-1184.
Bibtex
@article{bad5956f828d4ad3b536c74344c97768,
title = "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals",
abstract = "To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.",
author = "Ehret, {Georg B} and Teresa Ferreira and Chasman, {Daniel I} and Jackson, {Anne U} and Schmidt, {Ellen M} and Toby Johnson and Gudmar Thorleifsson and Jian'an Luan and Donnelly, {Louise A} and Stavroula Kanoni and Ann-Kristin Petersen and Vasyl Pihur and Strawbridge, {Rona J} and Dmitry Shungin and Hughes, {Maria F} and Osorio Meirelles and Marika Kaakinen and Nabila Bouatia-Naji and Kati Kristiansson and Sonia Shah and Kleber, {Marcus E} and Xiuqing Guo and Leo-Pekka Lyytik{\"a}inen and Cristiano Fava and Niclas Eriksson and Nolte, {Ilja M} and Magnusson, {Patrik K} and Salfati, {Elias L} and Rallidis, {Loukianos S} and Elizabeth Theusch and Smith, {Andrew J P} and Lasse Folkersen and Kate Witkowska and Pers, {Tune H} and Roby Joehanes and Kim, {Stuart K} and Lazaros Lataniotis and Rick Jansen and Johnson, {Andrew D} and Helen Warren and Kim, {Young Jin} and Wei Zhao and Ying Wu and Tayo, {Bamidele O} and Murielle Bochud and Devin Absher and Adair, {Linda S} and Najaf Amin and Inger Nj{\o}lstad and Schwarz, {Peter E H} and {CHARGE-EchoGen Consortium}",
year = "2016",
month = sep,
day = "12",
doi = "10.1038/ng.3667",
language = "English",
volume = "48",
pages = "1171--1184",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "10",
}
RIS
TY - JOUR
T1 - The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
AU - Ehret, Georg B
AU - Ferreira, Teresa
AU - Chasman, Daniel I
AU - Jackson, Anne U
AU - Schmidt, Ellen M
AU - Johnson, Toby
AU - Thorleifsson, Gudmar
AU - Luan, Jian'an
AU - Donnelly, Louise A
AU - Kanoni, Stavroula
AU - Petersen, Ann-Kristin
AU - Pihur, Vasyl
AU - Strawbridge, Rona J
AU - Shungin, Dmitry
AU - Hughes, Maria F
AU - Meirelles, Osorio
AU - Kaakinen, Marika
AU - Bouatia-Naji, Nabila
AU - Kristiansson, Kati
AU - Shah, Sonia
AU - Kleber, Marcus E
AU - Guo, Xiuqing
AU - Lyytikäinen, Leo-Pekka
AU - Fava, Cristiano
AU - Eriksson, Niclas
AU - Nolte, Ilja M
AU - Magnusson, Patrik K
AU - Salfati, Elias L
AU - Rallidis, Loukianos S
AU - Theusch, Elizabeth
AU - Smith, Andrew J P
AU - Folkersen, Lasse
AU - Witkowska, Kate
AU - Pers, Tune H
AU - Joehanes, Roby
AU - Kim, Stuart K
AU - Lataniotis, Lazaros
AU - Jansen, Rick
AU - Johnson, Andrew D
AU - Warren, Helen
AU - Kim, Young Jin
AU - Zhao, Wei
AU - Wu, Ying
AU - Tayo, Bamidele O
AU - Bochud, Murielle
AU - Absher, Devin
AU - Adair, Linda S
AU - Amin, Najaf
AU - Njølstad, Inger
AU - Schwarz, Peter E H
AU - CHARGE-EchoGen Consortium
PY - 2016/9/12
Y1 - 2016/9/12
N2 - To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
AB - To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
U2 - 10.1038/ng.3667
DO - 10.1038/ng.3667
M3 - Journal article
C2 - 27618452
VL - 48
SP - 1171
EP - 1184
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -
