The genetics of obesity: from discovery to biology

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The genetics of obesity : from discovery to biology. / Loos, Ruth J.F.; Yeo, Giles S.H.

In: Nature Reviews Genetics, Vol. 23, 2021, p. 120-133.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Loos, RJF & Yeo, GSH 2021, 'The genetics of obesity: from discovery to biology', Nature Reviews Genetics, vol. 23, pp. 120-133. https://doi.org/10.1038/s41576-021-00414-z

APA

Loos, R. J. F., & Yeo, G. S. H. (2021). The genetics of obesity: from discovery to biology. Nature Reviews Genetics, 23, 120-133. https://doi.org/10.1038/s41576-021-00414-z

Vancouver

Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nature Reviews Genetics. 2021;23:120-133. https://doi.org/10.1038/s41576-021-00414-z

Author

Loos, Ruth J.F. ; Yeo, Giles S.H. / The genetics of obesity : from discovery to biology. In: Nature Reviews Genetics. 2021 ; Vol. 23. pp. 120-133.

Bibtex

@article{a03af88ff06f4b9f969cfbea727d33d1,
title = "The genetics of obesity: from discovery to biology",
abstract = "The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people{\textquoteright}s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.",
author = "Loos, {Ruth J.F.} and Yeo, {Giles S.H.}",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Nature Limited.",
year = "2021",
doi = "10.1038/s41576-021-00414-z",
language = "English",
volume = "23",
pages = "120--133",
journal = "Nature Reviews. Genetics",
issn = "1471-0056",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The genetics of obesity

T2 - from discovery to biology

AU - Loos, Ruth J.F.

AU - Yeo, Giles S.H.

N1 - Publisher Copyright: © 2021, Springer Nature Limited.

PY - 2021

Y1 - 2021

N2 - The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.

AB - The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.

U2 - 10.1038/s41576-021-00414-z

DO - 10.1038/s41576-021-00414-z

M3 - Review

C2 - 34556834

AN - SCOPUS:85115429429

VL - 23

SP - 120

EP - 133

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

ER -

ID: 281163638