The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk

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The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk. / Stinson, Sara Elizabeth; Kromann Reim, Pauline; Lund, Morten Asp Vonsild; Lausten-Thomsen, Ulrik; Aas Holm, Louise; Huang, Yun; Brøns, Charlotte; Vaag, Allan; Thiele, Maja; Krag, Aleksander; Fonvig, Cilius Esmann; Grarup, Niels; Pedersen, Oluf; Christiansen, Michael; Ängquist, Lars; Sørensen, Thorkild I.A.; Holm, Jens-Christian; Hansen, Torben.

In: EBioMedicine, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stinson, SE, Kromann Reim, P, Lund, MAV, Lausten-Thomsen, U, Aas Holm, L, Huang, Y, Brøns, C, Vaag, A, Thiele, M, Krag, A, Fonvig, CE, Grarup, N, Pedersen, O, Christiansen, M, Ängquist, L, Sørensen, TIA, Holm, J-C & Hansen, T 2024, 'The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk', EBioMedicine. https://doi.org/10.1016/j.ebiom.2024.105205

APA

Stinson, S. E., Kromann Reim, P., Lund, M. A. V., Lausten-Thomsen, U., Aas Holm, L., Huang, Y., Brøns, C., Vaag, A., Thiele, M., Krag, A., Fonvig, C. E., Grarup, N., Pedersen, O., Christiansen, M., Ängquist, L., Sørensen, T. I. A., Holm, J-C., & Hansen, T. (2024). The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk. EBioMedicine, [105205]. https://doi.org/10.1016/j.ebiom.2024.105205

Vancouver

Stinson SE, Kromann Reim P, Lund MAV, Lausten-Thomsen U, Aas Holm L, Huang Y et al. The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk. EBioMedicine. 2024. 105205. https://doi.org/10.1016/j.ebiom.2024.105205

Author

Stinson, Sara Elizabeth ; Kromann Reim, Pauline ; Lund, Morten Asp Vonsild ; Lausten-Thomsen, Ulrik ; Aas Holm, Louise ; Huang, Yun ; Brøns, Charlotte ; Vaag, Allan ; Thiele, Maja ; Krag, Aleksander ; Fonvig, Cilius Esmann ; Grarup, Niels ; Pedersen, Oluf ; Christiansen, Michael ; Ängquist, Lars ; Sørensen, Thorkild I.A. ; Holm, Jens-Christian ; Hansen, Torben. / The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk. In: EBioMedicine. 2024.

Bibtex

@article{2a5854ac045c4f398ed2127af3594028,
title = "The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk",
abstract = "BACKGROUND: Birth weight (BW) is associated with risk of cardiometabolic disease (CMD) in adulthood, which may depend on the state of obesity, in particular if developed at a young age. We hypothesised that BW and a polygenic score (PGS) for BW were associated with cardiometabolic risk and related plasma protein levels in children and adolescents. We aimed to determine the modifying effect of childhood obesity on these associations.METHODS: We used data from The cross-sectional HOLBAEK Study with 4263 participants (median [IQR] age, 11.7 [9.2, 14.3] years; 57.1% girls and 42.9% boys; 48.6% from an obesity clinic and 51.4% from a population-based group). We gathered information on BW and gestational age, anthropometrics, cardiometabolic risk factors, calculated a PGS for BW, and measured plasma proteins using Olink Inflammation and Cardiovascular II panels. We employed multiple linear regression to examine the associations with BW as a continuous variable and performed interaction analyses to assess the effect of childhood obesity on cardiometabolic risk and plasma protein levels.FINDINGS: BW and a PGS for BW associated with cardiometabolic risk and plasma protein levels in childhood and adolescence. Childhood obesity modified the associations between BW and measures of insulin resistance, including HOMA-IR (βadj [95% CI per SD] for obesity: -0.12 [-0.15, -0.08]; normal weight: -0.04 [-0.08, 0.00]; Pinteraction = 0.004), c-peptide (obesity: -0.11 [-0.14, -0.08]; normal weight: -0.02 [-0.06, 0.02]; Pinteraction = 5.05E-04), and SBP SDS (obesity: -0.12 [-0.16, -0.08]; normal weight: -0.06 [-0.11, -0.01]; Pinteraction = 0.0479). Childhood obesity also modified the associations between BW and plasma levels of 14 proteins (e.g., IL15RA, MCP1, and XCL1; Pinteraction < 0.05).INTERPRETATION: We identified associations between lower BW and adverse metabolic phenotypes, particularly insulin resistance, blood pressure, and altered plasma protein levels, which were more pronounced in children with obesity. Developing effective prevention and treatment strategies for this group is needed to reduce the risk of future CMD.FUNDING: Novo Nordisk Foundation (NNF15OC0016544, NNF0064142 to T.H., NNF15OC0016692 to T.H. and A.K., NNF18CC0033668 to S.E.S, NNF18SA0034956 to C.E.F., NNF20SA0067242 to DCA, NNF18CC0034900 to NNF CBMR), The Innovation Fund Denmark (0603-00484B to T.H.), The Danish Cardiovascular Academy (DCA) and the Danish Heart Foundation (HF) (PhD2021007-DCA to P.K.R, 18-R125-A8447-22088 (HF) and 21-R149-A10071-22193 (HF) to M.A.V.L., PhD2023009-HF to L.A.H), EU Horizon (668031, 847989, 825694, 964590 to A.K.), Innovative Health Initiative (101132901 for A.K.), A.P. M{\o}ller Foundation (19-L-0366 to T.H.), The Danish National Research Foundation, Steno Diabetes Center Sj{\ae}lland, and The Region Zealand and Southern Denmark Health Scientific Research Foundation.",
author = "Stinson, {Sara Elizabeth} and {Kromann Reim}, Pauline and Lund, {Morten Asp Vonsild} and Ulrik Lausten-Thomsen and {Aas Holm}, Louise and Yun Huang and Charlotte Br{\o}ns and Allan Vaag and Maja Thiele and Aleksander Krag and Fonvig, {Cilius Esmann} and Niels Grarup and Oluf Pedersen and Michael Christiansen and Lars {\"A}ngquist and S{\o}rensen, {Thorkild I.A.} and Jens-Christian Holm and Torben Hansen",
note = "Copyright {\textcopyright} 2024 The Author(s). Published by Elsevier B.V. All rights reserved.",
year = "2024",
doi = "10.1016/j.ebiom.2024.105205",
language = "English",
journal = "EBioMedicine",
issn = "2352-3964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk

AU - Stinson, Sara Elizabeth

AU - Kromann Reim, Pauline

AU - Lund, Morten Asp Vonsild

AU - Lausten-Thomsen, Ulrik

AU - Aas Holm, Louise

AU - Huang, Yun

AU - Brøns, Charlotte

AU - Vaag, Allan

AU - Thiele, Maja

AU - Krag, Aleksander

AU - Fonvig, Cilius Esmann

AU - Grarup, Niels

AU - Pedersen, Oluf

AU - Christiansen, Michael

AU - Ängquist, Lars

AU - Sørensen, Thorkild I.A.

AU - Holm, Jens-Christian

AU - Hansen, Torben

N1 - Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Birth weight (BW) is associated with risk of cardiometabolic disease (CMD) in adulthood, which may depend on the state of obesity, in particular if developed at a young age. We hypothesised that BW and a polygenic score (PGS) for BW were associated with cardiometabolic risk and related plasma protein levels in children and adolescents. We aimed to determine the modifying effect of childhood obesity on these associations.METHODS: We used data from The cross-sectional HOLBAEK Study with 4263 participants (median [IQR] age, 11.7 [9.2, 14.3] years; 57.1% girls and 42.9% boys; 48.6% from an obesity clinic and 51.4% from a population-based group). We gathered information on BW and gestational age, anthropometrics, cardiometabolic risk factors, calculated a PGS for BW, and measured plasma proteins using Olink Inflammation and Cardiovascular II panels. We employed multiple linear regression to examine the associations with BW as a continuous variable and performed interaction analyses to assess the effect of childhood obesity on cardiometabolic risk and plasma protein levels.FINDINGS: BW and a PGS for BW associated with cardiometabolic risk and plasma protein levels in childhood and adolescence. Childhood obesity modified the associations between BW and measures of insulin resistance, including HOMA-IR (βadj [95% CI per SD] for obesity: -0.12 [-0.15, -0.08]; normal weight: -0.04 [-0.08, 0.00]; Pinteraction = 0.004), c-peptide (obesity: -0.11 [-0.14, -0.08]; normal weight: -0.02 [-0.06, 0.02]; Pinteraction = 5.05E-04), and SBP SDS (obesity: -0.12 [-0.16, -0.08]; normal weight: -0.06 [-0.11, -0.01]; Pinteraction = 0.0479). Childhood obesity also modified the associations between BW and plasma levels of 14 proteins (e.g., IL15RA, MCP1, and XCL1; Pinteraction < 0.05).INTERPRETATION: We identified associations between lower BW and adverse metabolic phenotypes, particularly insulin resistance, blood pressure, and altered plasma protein levels, which were more pronounced in children with obesity. Developing effective prevention and treatment strategies for this group is needed to reduce the risk of future CMD.FUNDING: Novo Nordisk Foundation (NNF15OC0016544, NNF0064142 to T.H., NNF15OC0016692 to T.H. and A.K., NNF18CC0033668 to S.E.S, NNF18SA0034956 to C.E.F., NNF20SA0067242 to DCA, NNF18CC0034900 to NNF CBMR), The Innovation Fund Denmark (0603-00484B to T.H.), The Danish Cardiovascular Academy (DCA) and the Danish Heart Foundation (HF) (PhD2021007-DCA to P.K.R, 18-R125-A8447-22088 (HF) and 21-R149-A10071-22193 (HF) to M.A.V.L., PhD2023009-HF to L.A.H), EU Horizon (668031, 847989, 825694, 964590 to A.K.), Innovative Health Initiative (101132901 for A.K.), A.P. Møller Foundation (19-L-0366 to T.H.), The Danish National Research Foundation, Steno Diabetes Center Sjælland, and The Region Zealand and Southern Denmark Health Scientific Research Foundation.

AB - BACKGROUND: Birth weight (BW) is associated with risk of cardiometabolic disease (CMD) in adulthood, which may depend on the state of obesity, in particular if developed at a young age. We hypothesised that BW and a polygenic score (PGS) for BW were associated with cardiometabolic risk and related plasma protein levels in children and adolescents. We aimed to determine the modifying effect of childhood obesity on these associations.METHODS: We used data from The cross-sectional HOLBAEK Study with 4263 participants (median [IQR] age, 11.7 [9.2, 14.3] years; 57.1% girls and 42.9% boys; 48.6% from an obesity clinic and 51.4% from a population-based group). We gathered information on BW and gestational age, anthropometrics, cardiometabolic risk factors, calculated a PGS for BW, and measured plasma proteins using Olink Inflammation and Cardiovascular II panels. We employed multiple linear regression to examine the associations with BW as a continuous variable and performed interaction analyses to assess the effect of childhood obesity on cardiometabolic risk and plasma protein levels.FINDINGS: BW and a PGS for BW associated with cardiometabolic risk and plasma protein levels in childhood and adolescence. Childhood obesity modified the associations between BW and measures of insulin resistance, including HOMA-IR (βadj [95% CI per SD] for obesity: -0.12 [-0.15, -0.08]; normal weight: -0.04 [-0.08, 0.00]; Pinteraction = 0.004), c-peptide (obesity: -0.11 [-0.14, -0.08]; normal weight: -0.02 [-0.06, 0.02]; Pinteraction = 5.05E-04), and SBP SDS (obesity: -0.12 [-0.16, -0.08]; normal weight: -0.06 [-0.11, -0.01]; Pinteraction = 0.0479). Childhood obesity also modified the associations between BW and plasma levels of 14 proteins (e.g., IL15RA, MCP1, and XCL1; Pinteraction < 0.05).INTERPRETATION: We identified associations between lower BW and adverse metabolic phenotypes, particularly insulin resistance, blood pressure, and altered plasma protein levels, which were more pronounced in children with obesity. Developing effective prevention and treatment strategies for this group is needed to reduce the risk of future CMD.FUNDING: Novo Nordisk Foundation (NNF15OC0016544, NNF0064142 to T.H., NNF15OC0016692 to T.H. and A.K., NNF18CC0033668 to S.E.S, NNF18SA0034956 to C.E.F., NNF20SA0067242 to DCA, NNF18CC0034900 to NNF CBMR), The Innovation Fund Denmark (0603-00484B to T.H.), The Danish Cardiovascular Academy (DCA) and the Danish Heart Foundation (HF) (PhD2021007-DCA to P.K.R, 18-R125-A8447-22088 (HF) and 21-R149-A10071-22193 (HF) to M.A.V.L., PhD2023009-HF to L.A.H), EU Horizon (668031, 847989, 825694, 964590 to A.K.), Innovative Health Initiative (101132901 for A.K.), A.P. Møller Foundation (19-L-0366 to T.H.), The Danish National Research Foundation, Steno Diabetes Center Sjælland, and The Region Zealand and Southern Denmark Health Scientific Research Foundation.

U2 - 10.1016/j.ebiom.2024.105205

DO - 10.1016/j.ebiom.2024.105205

M3 - Journal article

C2 - 38918147

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

M1 - 105205

ER -

ID: 396644290