The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System
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The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells : In Search of a Balanced Immune System. / Luo, Annie; Leach, Steven T; Barres, Romain; Hesson, Luke B; Grimm, Michael C; Simar, David.
In: Frontiers in Immunology, Vol. 8, 417, 2017.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells
T2 - In Search of a Balanced Immune System
AU - Luo, Annie
AU - Leach, Steven T
AU - Barres, Romain
AU - Hesson, Luke B
AU - Grimm, Michael C
AU - Simar, David
PY - 2017
Y1 - 2017
N2 - Immune cells not only affect tissue homeostasis at the site of inflammation but also exert systemic effects contributing to multiple chronic conditions. Recent evidence clearly supports an altered T helper 17/regulatory T cell (Th17/Treg) balance leading to the development and progression of inflammatory diseases that not only affect the gastrointestinal tract but also have whole-body manifestations, including insulin resistance. Epigenetic mechanisms are amenable to both environmental and circulating factors and contribute to determining the T cell landscape. The recently identified participation of the gut microbiota in the remodeling of the epigenome of immune cells has triggered a paradigm shift in our understanding of the etiology of various inflammatory diseases and opened new paths toward therapeutic strategies. In this review, we provide an overview of the contribution of the Th17/Treg balance in the development and progression of inflammatory bowel diseases and metabolic diseases. We discuss the involvement of epigenetic mechanisms in the regulation of T cell function in the particular context of dysbiosis. Finally, we examine the potential for nutritional interventions affecting the gut microbiota to reshape the T cell epigenome and address the inflammatory component of various diseases.
AB - Immune cells not only affect tissue homeostasis at the site of inflammation but also exert systemic effects contributing to multiple chronic conditions. Recent evidence clearly supports an altered T helper 17/regulatory T cell (Th17/Treg) balance leading to the development and progression of inflammatory diseases that not only affect the gastrointestinal tract but also have whole-body manifestations, including insulin resistance. Epigenetic mechanisms are amenable to both environmental and circulating factors and contribute to determining the T cell landscape. The recently identified participation of the gut microbiota in the remodeling of the epigenome of immune cells has triggered a paradigm shift in our understanding of the etiology of various inflammatory diseases and opened new paths toward therapeutic strategies. In this review, we provide an overview of the contribution of the Th17/Treg balance in the development and progression of inflammatory bowel diseases and metabolic diseases. We discuss the involvement of epigenetic mechanisms in the regulation of T cell function in the particular context of dysbiosis. Finally, we examine the potential for nutritional interventions affecting the gut microbiota to reshape the T cell epigenome and address the inflammatory component of various diseases.
KW - Journal Article
KW - Review
U2 - 10.3389/fimmu.2017.00417
DO - 10.3389/fimmu.2017.00417
M3 - Review
C2 - 28443096
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 417
ER -
ID: 182973038