The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. / Perry, Rachel J; Samuel, Varman T.; Petersen, Kitt Mia Falck; Shulmann, Gerald I.

In: Nature, Vol. 510, 05.06.2014, p. 84-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perry, RJ, Samuel, VT, Petersen, KMF & Shulmann, GI 2014, 'The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes', Nature, vol. 510, pp. 84-91. https://doi.org/10.1038/nature13478

APA

Perry, R. J., Samuel, V. T., Petersen, K. M. F., & Shulmann, G. I. (2014). The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature, 510, 84-91. https://doi.org/10.1038/nature13478

Vancouver

Perry RJ, Samuel VT, Petersen KMF, Shulmann GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 2014 Jun 5;510:84-91. https://doi.org/10.1038/nature13478

Author

Perry, Rachel J ; Samuel, Varman T. ; Petersen, Kitt Mia Falck ; Shulmann, Gerald I. / The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. In: Nature. 2014 ; Vol. 510. pp. 84-91.

Bibtex

@article{6b30ab75eaa44efd8a8999882ed8caf8,
title = "The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes",
abstract = "Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.",
author = "Perry, {Rachel J} and Samuel, {Varman T.} and Petersen, {Kitt Mia Falck} and Shulmann, {Gerald I.}",
year = "2014",
month = jun,
day = "5",
doi = "10.1038/nature13478",
language = "English",
volume = "510",
pages = "84--91",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

AU - Perry, Rachel J

AU - Samuel, Varman T.

AU - Petersen, Kitt Mia Falck

AU - Shulmann, Gerald I.

PY - 2014/6/5

Y1 - 2014/6/5

N2 - Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

AB - Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

U2 - 10.1038/nature13478

DO - 10.1038/nature13478

M3 - Journal article

C2 - 24899308

VL - 510

SP - 84

EP - 91

JO - Nature

JF - Nature

SN - 0028-0836

ER -

ID: 163099320