Time trends in epigenetic signatures and population health risks
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Time trends in epigenetic signatures and population health risks. / Sørensen, Thorkild I.A.; Barrès, Romain.
Twin and Family Studies of Epigenetics. ed. / Shuai Li; John L. Hopper. Elsevier Ltd. Academic Press, 2021. p. 285-298 (Translational Epigenetics, Vol. 27).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Time trends in epigenetic signatures and population health risks
AU - Sørensen, Thorkild I.A.
AU - Barrès, Romain
N1 - Publisher Copyright: © 2021 Elsevier Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Time trends in population health risks, whether manifest in risk factors or morbidity and mortality, are an essential challenge to manage in public health. This chapter discusses the assessment and prediction of time trends in health risks, environmental factors driving the time trends, early life environmental exposures with lag time effects, epigenetics as biological memory of early life environmental exposures, birth cohorts, age, and period effects in time trends in health risks, early life epigenetic signatures as predictors of later time trends in health risks, time trends among twin pairs characterizing the time trends, investigative requirements for the twin studies, gene-environment interactions possibly implicating epigenetics, current feasibility limitations in investigations and modifications of epigenetic. While time trend studies in epigenetics have not been carried out yet, the potentials and the challenges are emerging and should inspire future research elucidating causes, correlates, and consequences of epigenetically related traits.
AB - Time trends in population health risks, whether manifest in risk factors or morbidity and mortality, are an essential challenge to manage in public health. This chapter discusses the assessment and prediction of time trends in health risks, environmental factors driving the time trends, early life environmental exposures with lag time effects, epigenetics as biological memory of early life environmental exposures, birth cohorts, age, and period effects in time trends in health risks, early life epigenetic signatures as predictors of later time trends in health risks, time trends among twin pairs characterizing the time trends, investigative requirements for the twin studies, gene-environment interactions possibly implicating epigenetics, current feasibility limitations in investigations and modifications of epigenetic. While time trend studies in epigenetics have not been carried out yet, the potentials and the challenges are emerging and should inspire future research elucidating causes, correlates, and consequences of epigenetically related traits.
KW - Biological memory
KW - Early life environmental factors
KW - Epigenetics
KW - Gene-environment interactions
KW - Lag time effects
KW - Population health risks
KW - Public health
KW - Time trends
KW - Twin studies of time trends
U2 - 10.1016/B978-0-12-820951-6.00006-5
DO - 10.1016/B978-0-12-820951-6.00006-5
M3 - Book chapter
AN - SCOPUS:85129121929
T3 - Translational Epigenetics
SP - 285
EP - 298
BT - Twin and Family Studies of Epigenetics
A2 - Li, Shuai
A2 - Hopper, John L.
PB - Elsevier Ltd. Academic Press
ER -
ID: 306971477