Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. / Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

In: Diabetes Care, Vol. 47, No. 6, 2024, p. 1042-1047.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium 2024, 'Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes', Diabetes Care, vol. 47, no. 6, pp. 1042-1047. https://doi.org/10.2337/dc23-2274

APA

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (2024). Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care, 47(6), 1042-1047. https://doi.org/10.2337/dc23-2274

Vancouver

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care. 2024;47(6):1042-1047. https://doi.org/10.2337/dc23-2274

Author

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. / Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. In: Diabetes Care. 2024 ; Vol. 47, No. 6. pp. 1042-1047.

Bibtex

@article{2155041bbb1d46eb811347173942418c,
title = "Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes",
abstract = "OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16). CONCLUSIONS: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.",
author = "Kwak, {Soo Heon} and Hernandez-Cancela, {Ryan B.} and DiCorpo, {Daniel A.} and Condon, {David E.} and Jordi Merino and Peitao Wu and Brody, {Jennifer A.} and Jie Yao and Xiuqing Guo and Fariba Ahmadizar and Mariah Meyer and Murat Sincan and Mercader, {Josep M.} and Sujin Lee and Jeffrey Haessler and Vy, {Ha My T.} and Zhaotong Lin and Armstrong, {Nicole D.} and Shaopeng Gu and Tsao, {Noah L.} and Lange, {Leslie A.} and Ningyuan Wang and Wiggins, {Kerri L.} and Stella Trompet and Simin Liu and Loos, {Ruth J.F.} and Renae Judy and Schroeder, {Philip H.} and Hasbani, {Natalie R.} and Bos, {Maxime M.} and Morrison, {Alanna C.} and Jackson, {Rebecca D.} and Reiner, {Alexander P.} and Manson, {Jo Ann E.} and Chaudhary, {Ninad S.} and Carmichael, {Lynn K.} and Chen, {Yii Der Ida} and Taylor, {Kent D.} and Mohsen Ghanbari and {van Meurs}, Joyce and Pitsillides, {Achilleas N.} and Psaty, {Bruce M.} and Raymond Noordam and Ron Do and Park, {Kyong Soo} and Jukema, {J. Wouter} and Maryam Kavousi and Adolfo Correa and Rich, {Stephen S.} and Damrauer, {Scott M.} and {Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium}",
note = "Publisher Copyright: {\textcopyright} 2024 by the American Diabetes Association.",
year = "2024",
doi = "10.2337/dc23-2274",
language = "English",
volume = "47",
pages = "1042--1047",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "6",

}

RIS

TY - JOUR

T1 - Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes

AU - Kwak, Soo Heon

AU - Hernandez-Cancela, Ryan B.

AU - DiCorpo, Daniel A.

AU - Condon, David E.

AU - Merino, Jordi

AU - Wu, Peitao

AU - Brody, Jennifer A.

AU - Yao, Jie

AU - Guo, Xiuqing

AU - Ahmadizar, Fariba

AU - Meyer, Mariah

AU - Sincan, Murat

AU - Mercader, Josep M.

AU - Lee, Sujin

AU - Haessler, Jeffrey

AU - Vy, Ha My T.

AU - Lin, Zhaotong

AU - Armstrong, Nicole D.

AU - Gu, Shaopeng

AU - Tsao, Noah L.

AU - Lange, Leslie A.

AU - Wang, Ningyuan

AU - Wiggins, Kerri L.

AU - Trompet, Stella

AU - Liu, Simin

AU - Loos, Ruth J.F.

AU - Judy, Renae

AU - Schroeder, Philip H.

AU - Hasbani, Natalie R.

AU - Bos, Maxime M.

AU - Morrison, Alanna C.

AU - Jackson, Rebecca D.

AU - Reiner, Alexander P.

AU - Manson, Jo Ann E.

AU - Chaudhary, Ninad S.

AU - Carmichael, Lynn K.

AU - Chen, Yii Der Ida

AU - Taylor, Kent D.

AU - Ghanbari, Mohsen

AU - van Meurs, Joyce

AU - Pitsillides, Achilleas N.

AU - Psaty, Bruce M.

AU - Noordam, Raymond

AU - Do, Ron

AU - Park, Kyong Soo

AU - Jukema, J. Wouter

AU - Kavousi, Maryam

AU - Correa, Adolfo

AU - Rich, Stephen S.

AU - Damrauer, Scott M.

AU - Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

N1 - Publisher Copyright: © 2024 by the American Diabetes Association.

PY - 2024

Y1 - 2024

N2 - OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16). CONCLUSIONS: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.

AB - OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16). CONCLUSIONS: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.

U2 - 10.2337/dc23-2274

DO - 10.2337/dc23-2274

M3 - Journal article

C2 - 38652672

AN - SCOPUS:85194013093

VL - 47

SP - 1042

EP - 1047

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 6

ER -

ID: 395627975