Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

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Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. / Friedrich, Björn; Weyrich, Peter; Stancáková, Alena; Wang, Jianjung; Kuusisto, Johanna; Laakso, Markku; Sesti, Giorgio; Succurro, Elena; Smith, Ulf; Hansen, Torben; Pedersen, Oluf; Machicao, Fausto; Schäfer, Silke; Lang, Florian; Risler, Teut; Ullrich, Susanne; Stefan, Norbert; Fritsche, Andreas; Häring, Hans-Ulrich.

In: PLoS ONE, Vol. 3, No. 11, 2008, p. e3506.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Friedrich, B, Weyrich, P, Stancáková, A, Wang, J, Kuusisto, J, Laakso, M, Sesti, G, Succurro, E, Smith, U, Hansen, T, Pedersen, O, Machicao, F, Schäfer, S, Lang, F, Risler, T, Ullrich, S, Stefan, N, Fritsche, A & Häring, H-U 2008, 'Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.', PLoS ONE, vol. 3, no. 11, pp. e3506. https://doi.org/10.1371/journal.pone.0003506

APA

Friedrich, B., Weyrich, P., Stancáková, A., Wang, J., Kuusisto, J., Laakso, M., Sesti, G., Succurro, E., Smith, U., Hansen, T., Pedersen, O., Machicao, F., Schäfer, S., Lang, F., Risler, T., Ullrich, S., Stefan, N., Fritsche, A., & Häring, H-U. (2008). Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. PLoS ONE, 3(11), e3506. https://doi.org/10.1371/journal.pone.0003506

Vancouver

Friedrich B, Weyrich P, Stancáková A, Wang J, Kuusisto J, Laakso M et al. Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. PLoS ONE. 2008;3(11):e3506. https://doi.org/10.1371/journal.pone.0003506

Author

Friedrich, Björn ; Weyrich, Peter ; Stancáková, Alena ; Wang, Jianjung ; Kuusisto, Johanna ; Laakso, Markku ; Sesti, Giorgio ; Succurro, Elena ; Smith, Ulf ; Hansen, Torben ; Pedersen, Oluf ; Machicao, Fausto ; Schäfer, Silke ; Lang, Florian ; Risler, Teut ; Ullrich, Susanne ; Stefan, Norbert ; Fritsche, Andreas ; Häring, Hans-Ulrich. / Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. In: PLoS ONE. 2008 ; Vol. 3, No. 11. pp. e3506.

Bibtex

@article{95eeaa70acd911ddb538000ea68e967b,
title = "Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.",
abstract = "HYPOTHESIS: Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans. METHODS: Three independent European populations were analyzed for the association of SGK1 gene (SGK) variations and insulin secretion traits. The German TUEF project provided the screening population (N = 725), and four tagging SNPs (rs1763527, rs1743966, rs1057293, rs9402571) were investigated. EUGENE2 (N = 827) served as a replication cohort for the detected associations. Finally, the detected associations were validated in the METSIM study, providing 3798 non-diabetic and 659 diabetic (type 2) individuals. RESULTS: Carriers of the minor G allele in rs9402571 had significantly higher C-peptide levels in the 2 h OGTT (+10.8%, p = 0.04; dominant model) and higher AUC(C-Peptide)/AUC(Glc) ratios (+7.5%, p = 0.04) compared to homozygous wild type TT carriers in the screening population. As interaction analysis for BMIxrs9402571 was significant (p = 0.04) for the endpoint insulin secretion, we stratified the TUEF cohort for BMI, using a cut off point of BMI = 25. The effect on insulin secretion only remained significant in lean TUEF participants (BMI< or =25). This finding was replicated in lean EUGENE2 rs9402571 minor allele carriers, who had a significantly higher AUC(Ins)/AUC(Glc) (TT: 226+/-7, XG: 246+/-9; p = 0.019). Accordingly, the METSIM trial revealed a lower prevalence of type 2 diabetes (OR: 0.85; 95%CI: 0.71-1.01; p = 0.065, dominant model) in rs9402571 minor allele carriers. CONCLUSIONS: The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM. Our study in three independent European populations supports the conclusion that SGK variability affects diabetes risk.",
author = "Bj{\"o}rn Friedrich and Peter Weyrich and Alena Stanc{\'a}kov{\'a} and Jianjung Wang and Johanna Kuusisto and Markku Laakso and Giorgio Sesti and Elena Succurro and Ulf Smith and Torben Hansen and Oluf Pedersen and Fausto Machicao and Silke Sch{\"a}fer and Florian Lang and Teut Risler and Susanne Ullrich and Norbert Stefan and Andreas Fritsche and Hans-Ulrich H{\"a}ring",
year = "2008",
doi = "10.1371/journal.pone.0003506",
language = "English",
volume = "3",
pages = "e3506",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

AU - Friedrich, Björn

AU - Weyrich, Peter

AU - Stancáková, Alena

AU - Wang, Jianjung

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Sesti, Giorgio

AU - Succurro, Elena

AU - Smith, Ulf

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Machicao, Fausto

AU - Schäfer, Silke

AU - Lang, Florian

AU - Risler, Teut

AU - Ullrich, Susanne

AU - Stefan, Norbert

AU - Fritsche, Andreas

AU - Häring, Hans-Ulrich

PY - 2008

Y1 - 2008

N2 - HYPOTHESIS: Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans. METHODS: Three independent European populations were analyzed for the association of SGK1 gene (SGK) variations and insulin secretion traits. The German TUEF project provided the screening population (N = 725), and four tagging SNPs (rs1763527, rs1743966, rs1057293, rs9402571) were investigated. EUGENE2 (N = 827) served as a replication cohort for the detected associations. Finally, the detected associations were validated in the METSIM study, providing 3798 non-diabetic and 659 diabetic (type 2) individuals. RESULTS: Carriers of the minor G allele in rs9402571 had significantly higher C-peptide levels in the 2 h OGTT (+10.8%, p = 0.04; dominant model) and higher AUC(C-Peptide)/AUC(Glc) ratios (+7.5%, p = 0.04) compared to homozygous wild type TT carriers in the screening population. As interaction analysis for BMIxrs9402571 was significant (p = 0.04) for the endpoint insulin secretion, we stratified the TUEF cohort for BMI, using a cut off point of BMI = 25. The effect on insulin secretion only remained significant in lean TUEF participants (BMI< or =25). This finding was replicated in lean EUGENE2 rs9402571 minor allele carriers, who had a significantly higher AUC(Ins)/AUC(Glc) (TT: 226+/-7, XG: 246+/-9; p = 0.019). Accordingly, the METSIM trial revealed a lower prevalence of type 2 diabetes (OR: 0.85; 95%CI: 0.71-1.01; p = 0.065, dominant model) in rs9402571 minor allele carriers. CONCLUSIONS: The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM. Our study in three independent European populations supports the conclusion that SGK variability affects diabetes risk.

AB - HYPOTHESIS: Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans. METHODS: Three independent European populations were analyzed for the association of SGK1 gene (SGK) variations and insulin secretion traits. The German TUEF project provided the screening population (N = 725), and four tagging SNPs (rs1763527, rs1743966, rs1057293, rs9402571) were investigated. EUGENE2 (N = 827) served as a replication cohort for the detected associations. Finally, the detected associations were validated in the METSIM study, providing 3798 non-diabetic and 659 diabetic (type 2) individuals. RESULTS: Carriers of the minor G allele in rs9402571 had significantly higher C-peptide levels in the 2 h OGTT (+10.8%, p = 0.04; dominant model) and higher AUC(C-Peptide)/AUC(Glc) ratios (+7.5%, p = 0.04) compared to homozygous wild type TT carriers in the screening population. As interaction analysis for BMIxrs9402571 was significant (p = 0.04) for the endpoint insulin secretion, we stratified the TUEF cohort for BMI, using a cut off point of BMI = 25. The effect on insulin secretion only remained significant in lean TUEF participants (BMI< or =25). This finding was replicated in lean EUGENE2 rs9402571 minor allele carriers, who had a significantly higher AUC(Ins)/AUC(Glc) (TT: 226+/-7, XG: 246+/-9; p = 0.019). Accordingly, the METSIM trial revealed a lower prevalence of type 2 diabetes (OR: 0.85; 95%CI: 0.71-1.01; p = 0.065, dominant model) in rs9402571 minor allele carriers. CONCLUSIONS: The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM. Our study in three independent European populations supports the conclusion that SGK variability affects diabetes risk.

U2 - 10.1371/journal.pone.0003506

DO - 10.1371/journal.pone.0003506

M3 - Journal article

C2 - 18985156

VL - 3

SP - e3506

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 11

ER -

ID: 8466553