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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. / Liu, Xueping; Helenius, Dorte; Skotte, Line; Beaumont, Robin N; Wielscher, Matthias; Geller, Frank; Juodakis, Julius; Mahajan, Anubha; Bradfield, Jonathan P; Lin, Frederick T J; Vogelezang, Suzanne; Bustamante, Mariona; Ahluwalia, Tarunveer S; Pitkänen, Niina; Wang, Carol A; Bacelis, Jonas; Borges, Maria C; Zhang, Ge; Bedell, Bruce A; Rossi, Robert M; Skogstrand, Kristin; Peng, Shouneng; Thompson, Wesley K; Appadurai, Vivek; Lawlor, Debbie A; Kalliala, Ilkka; Power, Christine; McCarthy, Mark I; Boyd, Heather A; Marazita, Mary L; Hakonarson, Hakon; Hayes, M Geoffrey; Scholtens, Denise M; Rivadeneira, Fernando; Jaddoe, Vincent W V; Vinding, Rebecca K; Bisgaard, Hans; Knight, Bridget A; Pahkala, Katja; Raitakari, Olli; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål R; Fadista, João; Schork, Andrew J; Nudel, Ron; Miller, Daniel E; Chen, Xiaoting; Weirauch, Matthew T; Mortensen, Preben Bo; Børglum, Anders D; Nordentoft, Merete; Mors, Ole; Hao, Ke; Ryckman, Kelli K; Hougaard, David M; Kottyan, Leah C; Pennell, Craig E; Lyytikainen, Leo-Pekka; Bønnelykke, Klaus; Vrijheid, Martine; Felix, Janine F; Lowe, William L; Grant, Struan F A; Hyppönen, Elina; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Muglia, Louis J; Murray, Jeffrey C; Freathy, Rachel M; Werge, Thomas M; Melbye, Mads; Buil, Alfonso; Feenstra, Bjarke.
In:
Nature Communications, Vol. 10, No. 1, 3927, 02.09.2019.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Liu, X, Helenius, D, Skotte, L, Beaumont, RN, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, JP, Lin, FTJ, Vogelezang, S, Bustamante, M
, Ahluwalia, TS, Pitkänen, N, Wang, CA, Bacelis, J, Borges, MC, Zhang, G, Bedell, BA, Rossi, RM, Skogstrand, K, Peng, S, Thompson, WK, Appadurai, V, Lawlor, DA, Kalliala, I, Power, C, McCarthy, MI, Boyd, HA, Marazita, ML, Hakonarson, H, Hayes, MG, Scholtens, DM, Rivadeneira, F, Jaddoe, VWV, Vinding, RK, Bisgaard, H, Knight, BA, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, PR, Fadista, J, Schork, AJ, Nudel, R, Miller, DE, Chen, X, Weirauch, MT, Mortensen, PB, Børglum, AD
, Nordentoft, M, Mors, O, Hao, K, Ryckman, KK, Hougaard, DM, Kottyan, LC, Pennell, CE, Lyytikainen, L-P
, Bønnelykke, K, Vrijheid, M, Felix, JF, Lowe, WL, Grant, SFA, Hyppönen, E, Jacobsson, B, Jarvelin, M-R, Muglia, LJ, Murray, JC, Freathy, RM
, Werge, TM, Melbye, M, Buil, A & Feenstra, B 2019, '
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration',
Nature Communications, vol. 10, no. 1, 3927.
https://doi.org/10.1038/s41467-019-11881-8APA
Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Wielscher, M., Geller, F., Juodakis, J., Mahajan, A., Bradfield, J. P., Lin, F. T. J., Vogelezang, S., Bustamante, M.
, Ahluwalia, T. S., Pitkänen, N., Wang, C. A., Bacelis, J., Borges, M. C., Zhang, G., Bedell, B. A., ... Feenstra, B. (2019).
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
Nature Communications,
10(1), [3927].
https://doi.org/10.1038/s41467-019-11881-8Vancouver
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F et al.
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
Nature Communications. 2019 Sep 2;10(1). 3927.
https://doi.org/10.1038/s41467-019-11881-8Author
Liu, Xueping ; Helenius, Dorte ; Skotte, Line ; Beaumont, Robin N ; Wielscher, Matthias ; Geller, Frank ; Juodakis, Julius ; Mahajan, Anubha ; Bradfield, Jonathan P ; Lin, Frederick T J ; Vogelezang, Suzanne ; Bustamante, Mariona ; Ahluwalia, Tarunveer S ; Pitkänen, Niina ; Wang, Carol A ; Bacelis, Jonas ; Borges, Maria C ; Zhang, Ge ; Bedell, Bruce A ; Rossi, Robert M ; Skogstrand, Kristin ; Peng, Shouneng ; Thompson, Wesley K ; Appadurai, Vivek ; Lawlor, Debbie A ; Kalliala, Ilkka ; Power, Christine ; McCarthy, Mark I ; Boyd, Heather A ; Marazita, Mary L ; Hakonarson, Hakon ; Hayes, M Geoffrey ; Scholtens, Denise M ; Rivadeneira, Fernando ; Jaddoe, Vincent W V ; Vinding, Rebecca K ; Bisgaard, Hans ; Knight, Bridget A ; Pahkala, Katja ; Raitakari, Olli ; Helgeland, Øyvind ; Johansson, Stefan ; Njølstad, Pål R ; Fadista, João ; Schork, Andrew J ; Nudel, Ron ; Miller, Daniel E ; Chen, Xiaoting ; Weirauch, Matthew T ; Mortensen, Preben Bo ; Børglum, Anders D ; Nordentoft, Merete ; Mors, Ole ; Hao, Ke ; Ryckman, Kelli K ; Hougaard, David M ; Kottyan, Leah C ; Pennell, Craig E ; Lyytikainen, Leo-Pekka ; Bønnelykke, Klaus ; Vrijheid, Martine ; Felix, Janine F ; Lowe, William L ; Grant, Struan F A ; Hyppönen, Elina ; Jacobsson, Bo ; Jarvelin, Marjo-Riitta ; Muglia, Louis J ; Murray, Jeffrey C ; Freathy, Rachel M ; Werge, Thomas M ; Melbye, Mads ; Buil, Alfonso ; Feenstra, Bjarke. / Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. In: Nature Communications. 2019 ; Vol. 10, No. 1.
Bibtex
@article{7a09561a7d6f477090e3d45e1908679a,
title = "Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration",
abstract = "The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.",
author = "Xueping Liu and Dorte Helenius and Line Skotte and Beaumont, {Robin N} and Matthias Wielscher and Frank Geller and Julius Juodakis and Anubha Mahajan and Bradfield, {Jonathan P} and Lin, {Frederick T J} and Suzanne Vogelezang and Mariona Bustamante and Ahluwalia, {Tarunveer S} and Niina Pitk{\"a}nen and Wang, {Carol A} and Jonas Bacelis and Borges, {Maria C} and Ge Zhang and Bedell, {Bruce A} and Rossi, {Robert M} and Kristin Skogstrand and Shouneng Peng and Thompson, {Wesley K} and Vivek Appadurai and Lawlor, {Debbie A} and Ilkka Kalliala and Christine Power and McCarthy, {Mark I} and Boyd, {Heather A} and Marazita, {Mary L} and Hakon Hakonarson and Hayes, {M Geoffrey} and Scholtens, {Denise M} and Fernando Rivadeneira and Jaddoe, {Vincent W V} and Vinding, {Rebecca K} and Hans Bisgaard and Knight, {Bridget A} and Katja Pahkala and Olli Raitakari and {\O}yvind Helgeland and Stefan Johansson and Nj{\o}lstad, {P{\aa}l R} and Jo{\~a}o Fadista and Schork, {Andrew J} and Ron Nudel and Miller, {Daniel E} and Xiaoting Chen and Weirauch, {Matthew T} and Mortensen, {Preben Bo} and B{\o}rglum, {Anders D} and Merete Nordentoft and Ole Mors and Ke Hao and Ryckman, {Kelli K} and Hougaard, {David M} and Kottyan, {Leah C} and Pennell, {Craig E} and Leo-Pekka Lyytikainen and Klaus B{\o}nnelykke and Martine Vrijheid and Felix, {Janine F} and Lowe, {William L} and Grant, {Struan F A} and Elina Hypp{\"o}nen and Bo Jacobsson and Marjo-Riitta Jarvelin and Muglia, {Louis J} and Murray, {Jeffrey C} and Freathy, {Rachel M} and Werge, {Thomas M} and Mads Melbye and Alfonso Buil and Bjarke Feenstra",
year = "2019",
month = sep,
day = "2",
doi = "10.1038/s41467-019-11881-8",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
AU - Liu, Xueping
AU - Helenius, Dorte
AU - Skotte, Line
AU - Beaumont, Robin N
AU - Wielscher, Matthias
AU - Geller, Frank
AU - Juodakis, Julius
AU - Mahajan, Anubha
AU - Bradfield, Jonathan P
AU - Lin, Frederick T J
AU - Vogelezang, Suzanne
AU - Bustamante, Mariona
AU - Ahluwalia, Tarunveer S
AU - Pitkänen, Niina
AU - Wang, Carol A
AU - Bacelis, Jonas
AU - Borges, Maria C
AU - Zhang, Ge
AU - Bedell, Bruce A
AU - Rossi, Robert M
AU - Skogstrand, Kristin
AU - Peng, Shouneng
AU - Thompson, Wesley K
AU - Appadurai, Vivek
AU - Lawlor, Debbie A
AU - Kalliala, Ilkka
AU - Power, Christine
AU - McCarthy, Mark I
AU - Boyd, Heather A
AU - Marazita, Mary L
AU - Hakonarson, Hakon
AU - Hayes, M Geoffrey
AU - Scholtens, Denise M
AU - Rivadeneira, Fernando
AU - Jaddoe, Vincent W V
AU - Vinding, Rebecca K
AU - Bisgaard, Hans
AU - Knight, Bridget A
AU - Pahkala, Katja
AU - Raitakari, Olli
AU - Helgeland, Øyvind
AU - Johansson, Stefan
AU - Njølstad, Pål R
AU - Fadista, João
AU - Schork, Andrew J
AU - Nudel, Ron
AU - Miller, Daniel E
AU - Chen, Xiaoting
AU - Weirauch, Matthew T
AU - Mortensen, Preben Bo
AU - Børglum, Anders D
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Hao, Ke
AU - Ryckman, Kelli K
AU - Hougaard, David M
AU - Kottyan, Leah C
AU - Pennell, Craig E
AU - Lyytikainen, Leo-Pekka
AU - Bønnelykke, Klaus
AU - Vrijheid, Martine
AU - Felix, Janine F
AU - Lowe, William L
AU - Grant, Struan F A
AU - Hyppönen, Elina
AU - Jacobsson, Bo
AU - Jarvelin, Marjo-Riitta
AU - Muglia, Louis J
AU - Murray, Jeffrey C
AU - Freathy, Rachel M
AU - Werge, Thomas M
AU - Melbye, Mads
AU - Buil, Alfonso
AU - Feenstra, Bjarke
PY - 2019/9/2
Y1 - 2019/9/2
N2 - The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.
AB - The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.
U2 - 10.1038/s41467-019-11881-8
DO - 10.1038/s41467-019-11881-8
M3 - Journal article
C2 - 31477735
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 3927
ER -
