Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites

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Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits : studies in 6018 whites. / Jensen, Dorit P; Urhammer, Søren A; Eiberg, Hans; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf.

In: Molecular Genetics and Metabolism, Vol. 89, No. 4, 2006, p. 360-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, DP, Urhammer, SA, Eiberg, H, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2006, 'Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites', Molecular Genetics and Metabolism, vol. 89, no. 4, pp. 360-7. https://doi.org/10.1016/j.ymgme.2006.06.003

APA

Jensen, D. P., Urhammer, S. A., Eiberg, H., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2006). Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites. Molecular Genetics and Metabolism, 89(4), 360-7. https://doi.org/10.1016/j.ymgme.2006.06.003

Vancouver

Jensen DP, Urhammer SA, Eiberg H, Borch-Johnsen K, Jørgensen T, Hansen T et al. Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites. Molecular Genetics and Metabolism. 2006;89(4):360-7. https://doi.org/10.1016/j.ymgme.2006.06.003

Author

Jensen, Dorit P ; Urhammer, Søren A ; Eiberg, Hans ; Borch-Johnsen, Knut ; Jørgensen, Torben ; Hansen, Torben ; Pedersen, Oluf. / Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits : studies in 6018 whites. In: Molecular Genetics and Metabolism. 2006 ; Vol. 89, No. 4. pp. 360-7.

Bibtex

@article{c3e5b70d029e4616b51182fcb4f47606,
title = "Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites",
abstract = "The first type 2 diabetes (T2D) gene to be identified in a genome wide scan followed by positional cloning was CAPN10 encoding the cysteine protease calpain-10. Subsequently, a large number of studies have investigated variation in CAPN10 in relation to T2D. Two CAPN10 single nucleotide polymorphisms (SNPs), the SNP43 (rs3792267) and the SNP44 (rs2975760), have been associated with T2D in some, but not all studies conducted in a wide range of ethnicities. We investigated the two SNPs for association with T2D in a relatively large, homogenous population of Danish whites (n = 1359 T2D cases, n = 4659 normoglycemic and glucose-tolerant control subjects), however, no significant associations of the SNP43 or the SNP44 variant with T2D were found. Neither were the two variants associated with obesity, and no association of either variant with diabetes-related quantitative traits was found in a study involving a population-based sample of 5698 middle-aged subjects. Meta-analyses, however, of the present and previously published studies involving 15,368 (SNP43) or 13,628 (SNP44) subjects yielded odds ratios of 1.09 (95% CI 1.02-1.16, p = 0.007) and 1.15 (1.07-1.23, p = 0.0002), respectively, for association with T2D. In conclusion, in a relatively large study sample of whites we found no consistent evidence of association of the CAPN10 SNP43 or SNP44 with T2D, obesity, or related quantitative traits, although meta-analyses of these two CAPN10 SNPs demonstrated an association with T2D.",
keywords = "Blood Glucose, Body Mass Index, Calpain, Case-Control Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Humans, Insulin, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide",
author = "Jensen, {Dorit P} and Urhammer, {S{\o}ren A} and Hans Eiberg and Knut Borch-Johnsen and Torben J{\o}rgensen and Torben Hansen and Oluf Pedersen",
year = "2006",
doi = "10.1016/j.ymgme.2006.06.003",
language = "English",
volume = "89",
pages = "360--7",
journal = "Molecular Genetics and Metabolism",
issn = "1096-7192",
publisher = "Academic Press",
number = "4",

}

RIS

TY - JOUR

T1 - Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits

T2 - studies in 6018 whites

AU - Jensen, Dorit P

AU - Urhammer, Søren A

AU - Eiberg, Hans

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2006

Y1 - 2006

N2 - The first type 2 diabetes (T2D) gene to be identified in a genome wide scan followed by positional cloning was CAPN10 encoding the cysteine protease calpain-10. Subsequently, a large number of studies have investigated variation in CAPN10 in relation to T2D. Two CAPN10 single nucleotide polymorphisms (SNPs), the SNP43 (rs3792267) and the SNP44 (rs2975760), have been associated with T2D in some, but not all studies conducted in a wide range of ethnicities. We investigated the two SNPs for association with T2D in a relatively large, homogenous population of Danish whites (n = 1359 T2D cases, n = 4659 normoglycemic and glucose-tolerant control subjects), however, no significant associations of the SNP43 or the SNP44 variant with T2D were found. Neither were the two variants associated with obesity, and no association of either variant with diabetes-related quantitative traits was found in a study involving a population-based sample of 5698 middle-aged subjects. Meta-analyses, however, of the present and previously published studies involving 15,368 (SNP43) or 13,628 (SNP44) subjects yielded odds ratios of 1.09 (95% CI 1.02-1.16, p = 0.007) and 1.15 (1.07-1.23, p = 0.0002), respectively, for association with T2D. In conclusion, in a relatively large study sample of whites we found no consistent evidence of association of the CAPN10 SNP43 or SNP44 with T2D, obesity, or related quantitative traits, although meta-analyses of these two CAPN10 SNPs demonstrated an association with T2D.

AB - The first type 2 diabetes (T2D) gene to be identified in a genome wide scan followed by positional cloning was CAPN10 encoding the cysteine protease calpain-10. Subsequently, a large number of studies have investigated variation in CAPN10 in relation to T2D. Two CAPN10 single nucleotide polymorphisms (SNPs), the SNP43 (rs3792267) and the SNP44 (rs2975760), have been associated with T2D in some, but not all studies conducted in a wide range of ethnicities. We investigated the two SNPs for association with T2D in a relatively large, homogenous population of Danish whites (n = 1359 T2D cases, n = 4659 normoglycemic and glucose-tolerant control subjects), however, no significant associations of the SNP43 or the SNP44 variant with T2D were found. Neither were the two variants associated with obesity, and no association of either variant with diabetes-related quantitative traits was found in a study involving a population-based sample of 5698 middle-aged subjects. Meta-analyses, however, of the present and previously published studies involving 15,368 (SNP43) or 13,628 (SNP44) subjects yielded odds ratios of 1.09 (95% CI 1.02-1.16, p = 0.007) and 1.15 (1.07-1.23, p = 0.0002), respectively, for association with T2D. In conclusion, in a relatively large study sample of whites we found no consistent evidence of association of the CAPN10 SNP43 or SNP44 with T2D, obesity, or related quantitative traits, although meta-analyses of these two CAPN10 SNPs demonstrated an association with T2D.

KW - Blood Glucose

KW - Body Mass Index

KW - Calpain

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.ymgme.2006.06.003

DO - 10.1016/j.ymgme.2006.06.003

M3 - Journal article

C2 - 16857402

VL - 89

SP - 360

EP - 367

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

SN - 1096-7192

IS - 4

ER -

ID: 38455302