Zeitgebers of skeletal muscle and implications for metabolic health
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Zeitgebers of skeletal muscle and implications for metabolic health. / Gabriel, Brendan M.; Zierath, Juleen R.
In: Journal of Physiology, Vol. 600, No. 5, 2022, p. 1027-1036.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Zeitgebers of skeletal muscle and implications for metabolic health
AU - Gabriel, Brendan M.
AU - Zierath, Juleen R.
N1 - Publisher Copyright: © 2021 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society
PY - 2022
Y1 - 2022
N2 - Metabolic health is a crucial area of current research, and is an outcome of innate physiology, and interactions with the environment. Environmental cues, such as the Earth's day-night rhythm, partly regulate diurnal hormones and metabolites. Circadian physiology consists of highly conserved biological processes over ∼24-h cycles, which are influenced by external cues (Zeitgebers – ‘time-keepers’). Skeletal muscle has diurnal variations of a large magnitude, owing in part to the strong nature of physical activity throughout the day and other external Zeitgebers. The orchestration of whole-body and skeletal muscle metabolism is a complex, finely tuned process, and molecular diurnal variations are regulated by a transcription-translation feedback loop controlled by the molecular clock, as well as non-transcriptional metabolic processes. The mitochondrion may play an important role in regulating diurnal metabolites within skeletal muscle, given its central role in the regulation of NAD+/NADH, O2, reactive oxygen species and redox metabolism. These molecular pathways display diurnal variation and illustrate the complex orchestration of circadian metabolism in skeletal muscle. Probably the most robust Zeitgeber of skeletal muscle is exercise, which alters glucose metabolism and flux, in addition to a range of other diurnal metabolic pathways. Indeed, performing exercise at different times of the day may alter metabolism and health outcomes in some cohorts. The objective of this Symposium Review is to briefly cover the current literature, and to speculate regarding future areas of research. Thus, we postulate that metabolic health may be optimized by altering the timing of external cues such as diet and exercise.
AB - Metabolic health is a crucial area of current research, and is an outcome of innate physiology, and interactions with the environment. Environmental cues, such as the Earth's day-night rhythm, partly regulate diurnal hormones and metabolites. Circadian physiology consists of highly conserved biological processes over ∼24-h cycles, which are influenced by external cues (Zeitgebers – ‘time-keepers’). Skeletal muscle has diurnal variations of a large magnitude, owing in part to the strong nature of physical activity throughout the day and other external Zeitgebers. The orchestration of whole-body and skeletal muscle metabolism is a complex, finely tuned process, and molecular diurnal variations are regulated by a transcription-translation feedback loop controlled by the molecular clock, as well as non-transcriptional metabolic processes. The mitochondrion may play an important role in regulating diurnal metabolites within skeletal muscle, given its central role in the regulation of NAD+/NADH, O2, reactive oxygen species and redox metabolism. These molecular pathways display diurnal variation and illustrate the complex orchestration of circadian metabolism in skeletal muscle. Probably the most robust Zeitgeber of skeletal muscle is exercise, which alters glucose metabolism and flux, in addition to a range of other diurnal metabolic pathways. Indeed, performing exercise at different times of the day may alter metabolism and health outcomes in some cohorts. The objective of this Symposium Review is to briefly cover the current literature, and to speculate regarding future areas of research. Thus, we postulate that metabolic health may be optimized by altering the timing of external cues such as diet and exercise.
KW - circadian rhythm
KW - exercise
KW - metabolic health
KW - obesity
KW - skeletal muscle
KW - type 2 diabetes
U2 - 10.1113/JP280884
DO - 10.1113/JP280884
M3 - Journal article
C2 - 33963554
AN - SCOPUS:85107293580
VL - 600
SP - 1027
EP - 1036
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 5
ER -
ID: 272419487