- Published
Genetic insights into resting heart rate and its role in cardiovascular disease
van de Vegte, Y. J., Eppinga, R. N., van der Ende, M. Y., Hagemeijer, Y. P., Mahendran, Y., Salfati, E., Smith, A. V., Tan, V. Y., Arking, D. E., Ntalla, I., Appel, E. V., Schurmann, C., Brody, J. A., Rueedi, R., Polasek, O., Sveinbjornsson, G., Lecoeur, C., Ladenvall, C., Zhao, J. H., Isaacs, A. & 31 others, , 2023, In: Nature Communications. 14, 4646.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices
Suleman, Sufyan, Madsen, Anne Lundager, Ängquist, Lars, Schubert, Mikkel, Linneberg, Allan René, Loos, Ruth, Hansen, Torben & Grarup, Niels, 2024, (Accepted/In press) In: Journal of Clinical Endocrinology and Metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Mace, A., Sidore, C., Trompet, S., Mangino, M. & 266 others, , 1 Nov 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X. J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., Pei, Y. & 168 others, , 2023, In: Nature Genetics. 55, 7, p. 1091-1105 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, , 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Hughes, O., Bentley, A. R., Breeze, C. E., Aguet, F., Xu, X., Nadkarni, G., Sun, Q., Lin, B. M., Gilliland, T., Meyer, M. C., Du, J., Raffield, L. M., Kramer, H., Morton, R. W., Gouveia, M. H., Atkinson, E. G., Valladares-Salgado, A., Wacher-Rodarte, N., Dueker, N. D., Guo, X. & 54 others, , 2024, In: Cell Genomics. 4, 1, 13 p., 100468.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Disorders in CKD across the Lifespan
Verbitsky, M., Krishnamurthy, S., Krithivasan, P., Hughes, D., Khan, A., Marasà, M., Vena, N., Khosla, P., Zhang, J., Lim, T. Y., Glessner, J. T., Weng, C., Shang, N., Shen, Y., Hripcsak, G., Hakonarson, H., Ionita-Laza, I., Levy, B., Kenny, E. E., Loos, R. J. F. & 11 others, , 2023, In: Journal of the American Society of Nephrology : JASN. 34, 4, p. 607-618 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomics and phenomics of body mass index reveals a complex disease network
Huang, J., Huffman, J. E., Huang, Y., Do Valle, Í., Assimes, T. L., Raghavan, S., Voight, B. F., Liu, C., Barabási, A. L., Huang, R. D. L., Hui, Q., Nguyen, X. M. T., Ho, Y. L., Djousse, L., Lynch, J. A., Vujkovic, M., Tcheandjieu, C., Tang, H., Damrauer, S. M., Reaven, P. D. & 19 others, , 2022, In: Nature Communications. 13, 1, 10 p., 7973.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Zhou, W., Kanai, M., Wu, K. H. H., Rasheed, H., Tsuo, K., Hirbo, J. B., Wang, Y., Bhattacharya, A., Zhao, H., Namba, S., Surakka, I., Wolford, B. N., Lo Faro, V., Lopera-Maya, E. A., Läll, K., Favé, M. J., Partanen, J. J., Chapman, S. B., Karjalainen, J., Kurki, M. & 54 others, , 2022, In: Cell Genomics. 2, 10, 20 p., 100192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Wang, Y., Namba, S., Lopera-Maya, E. A., Kerminen, S., Tsuo, K., Läll, K., Kanai, M., Zhou, W., Wu, K. H. H., Favé, M. J., Bhatta, L., Awadalla, P., Brumpton, B. M., Deelen, P., Hveem, K., Lo Faro, V., Mägi, R., Murakami, Y., Sanna, S., Smoller, J. W. & 49 others, , 2023, In: Cell Genomics. 3, 1, 18 p., 100241.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD PMDI, A. P., 2023, In: Communications Medicine. 3, 17 p., 133.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, , 2022, In: Genome Biology. 23, 1, 42 p., 268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
ADA/EASD PMDI, A. P., Merino, Jordi, Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen, Clemmensen, Christoffer, Hansen, Torben, Nakabuye, Mariam, Loos, Ruth, Guasch Ferre, Marta & Vilsbøll, Tina, 2024, In: Communications Medicine. 4, 1, 8 p., 66.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
Kjerulff, B., Dowsett, J., Jacobsen, R. L., Gladov, J., Larsen, M. H., Lundgaard, A. T., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K. M., Hindhede, L., Kaspersen, K. A., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C. B., Sabel, C. E., Bundgaard, H., Nielsen, H. S. & 30 others, , 2024, In: Communications Medicine. 4, 15 p., 50.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores
Hrytsenko, Y., Shea, B., Elgart, M., Kurniansyah, N., Lyons, G., Morrison, A. C., Carson, A. P., Haring, B., Mitchel, B. D., Psaty, B. M., Jaeger, B. C., Gu, C. C., Kooperberg, C., Levy, D., Lloyd-Jones, D., Choi, E., Brody, J. A., Smith, J. A., Rotter, J. I., Moll, M. & 18 others, , 2023, medRxiv, 41 p.Research output: Working paper › Preprint › Research
- Published
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Liao, R. G., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Andrews, S. J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E. C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M. A., Wendt, F. R., Savage, J., Sloofman, L. & 41 others, , 2021, In: Nature. 600, p. 472-477Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., Pampana, A., Gibson, C. J., Griffin, G. K., Clarke, S. L., Bhattacharya, R., Assimes, T. L., Emery, L. S., Stilp, A. M., Wong, Q., Broome, J. & 32 others, , 2022, In: Science Advances. 8, 14, eabl6579.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Jakubek, Y. A., Zhou, Y., Stilp, A., Bacon, J., Wong, J. W., Ozcan, Z., Arnett, D., Barnes, K., Bis, J. C., Boerwinkle, E., Brody, J. A., Carson, A. P., Chasman, D. I., Chen, J., Cho, M., Conomos, M. P., Cox, N., Doyle, M. F., Fornage, M., Guo, X. & 31 others, , 2023, In: Nature Genetics. 55, 11, p. 1912-1919 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, , 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., McQuillin, A., Bass, N. & 58 others, , 2024, In: Nature Genetics. 56, 2, p. 222–233Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
VA Million Veteran Program, V. M. V. P., 2023, medRxiv, 39 p.Research output: Working paper › Preprint › Research
- Published
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program
Small, A. M., Peloso, G. M., Linefsky, J., Aragam, J., Galloway, A., Tanukonda, V., Wang, L. C., Yu, Z., Sunitha Selvaraj, M., Farber-Eger, E. H., Baker, M. T., Setia-Verma, S., Lee, S. S. K., Preuss, M., Ritchie, M. D., Damrauer, S. M., Rader, D. J., Wells, Q. S., Loos, R., Lubitz, S. A. & 5 others, , 2023, In: Circulation. 147, 12, p. 942-955 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium
Flanagan, E. W., Spann, R., Berry, S. E., Berthoud, H. R., Broyles, S., Foster, G. D., Krakoff, J., Loos, Ruth, Lowe, M. R., Ostendorf, D. M., Powell-Wiley, T. M., Redman, L. M., Rosenbaum, M., Schauer, P. R., Seeley, R. J., Swinburn, B. A., Hall, K. & Ravussin, E., 2023, In: Obesity. 31, 12, p. 2895-2908Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
India-Aldana, S., Yao, M., Midya, V., Colicino, E., Chatzi, L., Chu, J., Gennings, C., Jones, D. P., Loos, Ruth, Setiawan, V. W., Smith, M. R., Walker, R. W., Barupal, D., Walker, D. I. & Valvi, D., 2023, In: Current Pollution Reports. 9, p. 510-568Research output: Contribution to journal › Review › Research › peer-review
- Published
Persistent thinness and anorexia nervosa differ on a genomic level
Hübel, C., Abdulkadir, M., Herle, M., Palmos, A. B., Loos, Ruth, Breen, G., Micali, Nadia & Bulik, C. M., 2024, In: European Journal of Human Genetics. 32, 1, p. 117-124Research output: Contribution to journal › Journal article › Research › peer-review
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Developmental language disorder – a comprehensive study of more than 46,000 individuals
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A saturated map of common genetic variants associated with human height
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children
Research output: Contribution to journal › Journal article › Research › peer-review
Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
Research output: Contribution to journal › Journal article › Research › peer-review
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Research output: Contribution to journal › Journal article › Research › peer-review