Loos Group

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  1. 2024
  2. Published

    Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop

    Aagaard, K. M., Barkin, S. L., Burant, C. F., Carnell, S., Demerath, E., Donovan, S. M., Eneli, I., Francis, L. A., Gilbert-Diamond, D., Hivert, M. F., LeBourgeois, M. K., Loos, R. J. F., Lumeng, J. C., Miller, A. L., Okely, A. D., Osganian, S. K., Ramirez, A. G., Trasande, L., Van Horn, L. V., Wake, M. & 2 others, Wright, R. J. & Yanovski, S. Z., 2024, In: Obesity Reviews. 25, 4, 21 p., e13690.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort

    Bjørnsbo, K. S., Brøns, C., Aadahl, M., Kampmann, F. B., Friis Bryde Nielsen, C., Lundbergh, B., Christensen, R. W., Kårhus, L. L., Madsen, A. L., Hansen, C. S., Nørgaard, K., Jørgensen, N. R., Suetta, C., Kjaer, M., Grarup, N., Kanters, J., Larsen, M., Køber, L., Kofoed, K. F., Loos, R. & 3 others, Hansen, Torben, Linneberg, Allan René & Vaag, Allan, 2024, In: BMJ Open. 14, 1, 10 p., e078501.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

    Carrasquilla, Germán D., Ängquist, Lars, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Loos, Ruth, 2024, In: Diabetologia. 67, p. 864–873 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A genomic mutational constraint map using variation in 76,156 human genomes

    Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y., Banks, E., Donnelly, S. & 18 others, Gabriel, S., Gupta, N., Ferriera, S., Tolonen, C., Novod, S., Bergelson, L., Roazen, D., Ruano-Rubio, V., Covarrubias, M., Llanwarne, C., Petrillo, N., Wade, G., Jeandet, T., Munshi, R., Tibbetts, K., Loos, Ruth, Karczewski, K. J. & Genome Aggregation Database Consortium, G. A. D. C., 2024, In: Nature. 625, 7993, p. 92-100 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

    ADA/EASD PMDI, A. P., Merino, Jordi, Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen, Clemmensen, Christoffer, Hansen, Torben, Nakabuye, Mariam, Loos, Ruth, Guasch Ferre, Marta & Vilsbøll, Tina, 2024, In: Communications Medicine. 4, 1, 8 p., 66.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability (FOREVER)—A cohort study in a Danish high street optician setting: Design and methodology

    Freiberg, J., Rovelt, J., Gazzard, G., Cour, M. L., Kolko, M., Torp‐Pedersen, C., Benn, M., Brunak, S., Cour, M. L., Tolstrup, J., Toft‐Petersen, A. P., Burgdorf, K. S., Banasik, K., Chmura, P. J., Freiberg, J., Rovelt, J., Thornit, D. N., Foster, P., Gazzard, G., Crabb, D. P. & 4 others, Viswanathan, A., Barman, Sarah, Owen, C. G. & Rudnicka, A. R., 2024, In: Acta Ophthalmologica. 102, 1, p. 80-90 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

    Hughes, O., Bentley, A. R., Breeze, C. E., Aguet, F., Xu, X., Nadkarni, G., Sun, Q., Lin, B. M., Gilliland, T., Meyer, M. C., Du, J., Raffield, L. M., Kramer, H., Morton, R. W., Gouveia, M. H., Atkinson, E. G., Valladares-Salgado, A., Wacher-Rodarte, N., Dueker, N. D., Guo, X. & 54 others, Hai, Y., Adeyemo, A., Best, L. G., Cai, J., Chen, G., Chong, M., Doumatey, A., Eales, J., Goodarzi, M. O., Ipp, E., Irvin, M. R., Jiang, M., Jones, A. C., Kooperberg, C., Krieger, J. E., Lange, E. M., Lanktree, M. B., Lash, J. P., Lotufo, P. A., Loos, Ruth, Ha My, V. T., Peralta-Romero, J., Qi, L., Raffel, L. J., Rich, S. S., Rodriquez, E. J., Tarazona-Santos, E., Taylor, K. D., Umans, J. G., Wen, J., Young, B. A., Yu, Z., Zhang, Y., Ida Chen, Y. D., Rundek, T., Rotter, J. I., Cruz, M., Fornage, M., Lima-Costa, M. F., Pereira, A. C., Paré, G., Natarajan, P., Cole, S. A., Carson, A. P., Lange, L. A., Li, Y., Perez-Stable, E. J., Do, R., Charchar, F. J., Tomaszewski, M., Mychaleckyj, J. C., Rotimi, C., Morris, A. P. & Franceschini, N., 2024, In: Cell Genomics. 4, 1, 13 p., 100468.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Persistent thinness and anorexia nervosa differ on a genomic level

    Hübel, C., Abdulkadir, M., Herle, M., Palmos, A. B., Loos, Ruth, Breen, G., Micali, Nadia & Bulik, C. M., 2024, In: European Journal of Human Genetics. 32, 1, p. 117-124

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

    Kjerulff, B., Dowsett, J., Jacobsen, R. L., Gladov, J., Larsen, M. H., Lundgaard, A. T., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K. M., Hindhede, L., Kaspersen, K. A., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C. B., Sabel, C. E., Bundgaard, H., Nielsen, H. S. & 30 others, Møller, J. A., Boldsen, J. K., Burgdorf, Kristoffer Sølvsten, Kessing, Lars Vedel, Handgaard, L. J., Thørner, L. W., Didriksen, Maria, Nyegaard, Mette, Grarup, Niels, Ødum, Niels, Johansson, P. I., Jennum, Poul, Frikke-Schmidt, Ruth, Berger, S. S., Brunak, Søren, Jacobsen, Søren, Hansen, Thomas Folkmann, Lundquist, T. K., Hansen, Torben, Sørensen, Torben Lykke, Sigsgaard, T., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Ullum, H., Rostgaard, K., Sørensen, E., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye & Erikstrup, C., 2024, In: Communications Medicine. 4, 15 p., 50.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

    Lennon, N. J., Kottyan, L. C., Kachulis, C., Abul-Husn, N. S., Arias, J., Belbin, G., Below, J. E., Berndt, S. I., Chung, W. K., Cimino, J. J., Clayton, E. W., Connolly, J. J., Crosslin, D. R., Dikilitas, O., Velez Edwards, D. R., Feng, Q. P., Fisher, M., Freimuth, R. R., Ge, T., Glessner, J. T. & 59 others, Gordon, A. S., Patterson, C., Hakonarson, H., Harden, M., Harr, M., Hirschhorn, J., Hoggart, C., Hsu, L., Irvin, M. R., Jarvik, G. P., Karlson, E. W., Khan, A., Khera, A., Kiryluk, K., Kullo, I., Larkin, K., Limdi, N., Linder, J. E., Loos, Ruth, Luo, Y., Malolepsza, E., Manolio, T. A., Martin, L. J., McCarthy, L., McNally, E. M., Meigs, J. B., Mersha, T. B., Mosley, J. D., Musick, A., Namjou, B., Pai, N., Pesce, L. L., Peters, U., Peterson, J. F., Prows, C. A., Puckelwartz, M. J., Rehm, H. L., Roden, D. M., Rosenthal, E. A., Rowley, R., Sawicki, K. T., Schaid, D. J., Smit, Roelof Adriaan Johan, Smith, J. L., Smoller, J. W., Thomas, M., Tiwari, H., Toledo, D. M., Vaitinadin, N. S., Veenstra, D., Walunas, T. L., Wang, Z., Wei, W. Q., Weng, C., Wiesner, G. L., Yin, X., Kenny, E. E., Berndt, S. & Hirschhorn, J., 2024, In: Nature Medicine. 30, 2, p. 480-487 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Genetic Variation and Obesity

    Loos, Ruth, 2024, Handbook of Obesity: Epidemiology, Etiology, and Physiopathology. Bray, G. A. & Bouchard, C. (eds.). 4 ed. CRC Press, Vol. 1. p. 113-122 10 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  13. Published

    Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

    Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., McQuillin, A., Bass, N. & 58 others, Chundru, V. K., Martin, H. C., Huang, Q. Q., Valkovskaya, M., Chu, C. Y., Kanjira, S., Kuo, P. H., Chen, H. C., Tsai, S. J., Liu, Y. L., Kendler, K. S., Peterson, R. E., Cai, N., Fang, Y., Sen, S., Scott, L. J., Burmeister, M., Loos, Ruth, Preuss, M. H., Actkins, K. E. V., Davis, L. K., Uddin, M., Wani, A. H., Wildman, D. E., Aiello, A. E., Ursano, R. J., Kessler, R. C., Kanai, M., Okada, Y., Sakaue, S., Rabinowitz, J. A., Maher, B. S., Uhl, G., Eaton, W., Cruz-Fuentes, C. S., Martinez-Levy, G. A., Campos, A. I., Millwood, I. Y., Chen, Z., Li, L., Wassertheil-Smoller, S., Jiang, Y., Tian, C., Martin, N. G., Mitchell, B. L., Byrne, E. M., Awasthi, S., Coleman, J. R. I., Ripke, S., Sofer, T., Walters, R. G., McIntosh, A. M., Polimanti, R., Dunn, E. C., Stein, M. B., Gelernter, J., Lewis, C. M. & Kuchenbaecker, K., 2024, In: Nature Genetics. 56, 2, p. 222–233

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children

    Renier, T. J., Yeum, D., Emond, J. A., Lansigan, R. K., Ballarino, G. A., Carlson, D. D., Loos, Ruth & Gilbert-Diamond, D., 2024, In: International Journal of Obesity. 48, p. 71-77

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Accepted/In press

    Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices

    Suleman, Sufyan, Madsen, Anne Lundager, Ängquist, Lars, Schubert, Mikkel, Linneberg, Allan René, Loos, Ruth, Hansen, Torben & Grarup, Niels, 2024, (Accepted/In press) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

    Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., Schroeder, P., Vanderwerff, B. & 31 others, Kals, M., Bragg, F., Lin, K., Guo, X., Zhang, W., Yao, J., Kim, Y. J., Graff, M., Takeuchi, F., Nano, J., Lamri, A., Nakatochi, M., Moon, S., Scott, R. A., Cook, J. P., Lee, J., Pan, I., Taliun, D., Parra, E. J., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Hansen, Torben, Pedersen, Oluf Borbye, Loos, Ruth & VA Million Veteran Program, V. M. V. P., 2024, In: Nature. 627, 8003, p. 347-357 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2023
  18. Published

    A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

    Aglago, E. K., Kim, A., Lin, Y., Qu, C., Evangelou, M., Ren, Y., Morrison, J., Albanes, D., Arndt, V., Barry, E. L., Baurley, J. W., Berndt, S. I., Bien, S. A., Bishop, D. T., Bouras, E., Brenner, H., Buchanan, D. D., Budiarto, A., Carreras-Torres, R., Casey, G. & 80 others, Cenggoro, T. W., Chan, A. T., Chang-Claude, J., Chen, X., Conti, D. V., Devall, M., Díez Obrero, Virginia, Dimou, N., Drew, D., Figueiredo, J. C., Gallinger, S., Giles, G. G., Gruber, S. B., Gsur, A., Gunter, M. J., Hampel, H., Harlid, S., Hidaka, A., Harrison, T. A., Hoffmeister, M., Huyghe, J. R., Jenkins, M. A., Jordahl, K., Joshi, A. D., Kawaguchi, E. S., Keku, T. O., Kundaje, A., Larsson, S. C., Marchand, L. L., Lewinger, J. P., Li, L., Lynch, B. M., Mahesworo, B., Mandic, M., Obón-Santacana, M., Moreno, V., Murphy, N., Nan, H., Nassir, R., Newcomb, P. A., Ogino, S., Ose, J., Pai, R. K., Palmer, J. R., Papadimitriou, N., Pardamean, B., Peoples, A. R., Platz, E. A., Potter, J. D., Prentice, R. L., Rennert, G., Ruiz-Narvaez, E., Sakoda, L. C., Scacheri, P. C., Schmit, S. L., Schoen, R. E., Shcherbina, A., Slattery, M. L., Stern, M. C., Su, Y. R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Tian, Y., Ulrich, C. M., van Duijnhoven, F. J., Van Guelpen, B., Visvanathan, K., Vodicka, P., Wang, J., White, E., Wolk, A., Woods, M. O., Wu, A. H., Zemlianskaia, N., Hsu, L., Gauderman, W. J., Peters, U., Tsilidis, K. K. & Campbell, P. T., 2023, In: Cancer Research. 83, 15, p. 2572-2583 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Approaches to addressing the rise in obesity levels

    Apovian, C. M., Guo, X. R., Hawley, J. A., Karmali, S., Loos, Ruth & Waterlander, W. E., 2023, In: Nature Reviews Endocrinology. 19, p. 76-81

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

    Bjornsdottir, G., Chalmer, M. A., Stefansdottir, L., Skuladottir, A. T., Einarsson, G., Andresdottir, M., Beyter, D., Ferkingstad, E., Gretarsdottir, S., Halldorsson, B. V., Halldorsson, G. H., Helgadottir, A., Helgason, H., Hjorleifsson Eldjarn, G., Jonasdottir, A., Jonasdottir, A., Jonsdottir, I., Knowlton, K. U., Nadauld, L. D., Lund, S. H. & 30 others, Magnusson, O. T., Melsted, P., Moore, K. H. S., Oddsson, A., Olason, P. I., Sigurdsson, A., Banasik, Karina, Brunak, Søren, Didriksen, Maria, Kogelman, L. J. A., Nielsen, K. R., Sørensen, E., Pedersen, Ole Birger Vesterager, Ullum, H., Bay, J., Burgdorf, Kristoffer Sølvsten, Dowsett, J., Hjalgrim, Henrik, Jacobsen, R. L., Louloudis, Ioannis, Lundgaard, Agnete Troen, Mikkelsen, Christina, Nyegaard, Mette, Henriksen, Alexander Pil, Werge, Thomas, Westergaard, David, Olesen, Jes, Ostrowski, Sisse Rye, Hansen, Thomas Folkmann & DBDS Genetic Consortium, D. G. C., 2023, In: Nature Genetics. 55, 11, p. 1843-1853

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

    Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD PMDI, A. P., 2023, In: Communications Medicine. 3, 17 p., 133.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review

    Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD Precision Medicine in Diabetes Initiative, A. P. M. I. D. I., 2023, medRxiv.

    Research output: Working paper › Preprint › Research

  23. Published

    Polygenic Scores Help Reduce Racial Disparities in Predictive Accuracy of Automated Type 1 Diabetes Classification Algorithms

    Deutsch, A. J., Stalbow, L., Majarian, T. D., Mercader, J. M., Manning, A. K., Florez, J. C., Loos, Ruth & Udler, M. S., 2023, In: Diabetes Care. 46, 4, p. 794-800 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins

    Figaroa, M. N. S., Gielen, M., Casas, L., Loos, Ruth, Derom, C., Weyers, S., Nawrot, T. S., Zeegers, M. P. & Bijnens, E. M., 2023, In: Environmental Health. 22, 13 p., 18.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium

    Flanagan, E. W., Spann, R., Berry, S. E., Berthoud, H. R., Broyles, S., Foster, G. D., Krakoff, J., Loos, Ruth, Lowe, M. R., Ostendorf, D. M., Powell-Wiley, T. M., Redman, L. M., Rosenbaum, M., Schauer, P. R., Seeley, R. J., Swinburn, B. A., Hall, K. & Ravussin, E., 2023, In: Obesity. 31, 12, p. 2895-2908

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations

    Gerhart-Hines, Zach & Loos, Ruth, 2023, In: Current Opinion in Genetics and Development. 83, 102117.

    Research output: Contribution to journal › Editorial › Research

  27. Published

    Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

    Gupta, Y., Friedman, D. J., McNulty, M. T., Khan, A., Lane, B., Wang, C., Ke, J., Jin, G., Wooden, B., Knob, A. L., Lim, T. Y., Appel, G. B., Huggins, K., Liu, L., Mitrotti, A., Stangl, M. C., Bomback, A., Westland, R., Bodria, M., Marasa, M. & 60 others, Shang, N., Cohen, D. J., Crew, R. J., Morello, W., Canetta, P., Radhakrishnan, J., Martino, J., Liu, Q., Chung, W. K., Espinoza, A., Luo, Y., Wei, W., Feng, Q., Weng, C., Fang, Y., Kullo, I. J., Naderian, M., Limdi, N., Irvin, M. R., Tiwari, H., Mohan, S., Rao, M., Dube, G. K., Chaudhary, N. S., Gutiérrez, O. M., Judd, S. E., Cushman, M., Lange, L. A., Lange, E. M., Bivona, D. L., Verbitsky, M., Winkler, C. A., Kopp, J. B., Santoriello, D., Batal, I., Pinheiro, S. V. B., Oliveira, E. A., Simoes e Silva, A. C., Pisani, I., Fiaccadori, E., Lin, F., Gesualdo, L., Amoroso, A., Ghiggeri, G. M., D’Agati, V. D., Magistroni, R., Kenny, E. E., Loos, Ruth, Montini, G., Hildebrandt, F., Paul, D. S., Petrovski, S., Goldstein, D. B., Kretzler, M., Gbadegesin, R., Gharavi, A. G., Kiryluk, K., Sampson, M. G., Pollak, M. R. & Sanna-Cherchi, S., 2023, In: Nature Communications. 14, 8 p., 7836.

    Research output: Contribution to journal › Journal article › Research › peer-review

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