Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation. / Kittrell, Hannah D.; DiMenna, Fred J.; Arad, Avigdor D.; Oh, Wonsuk; Hofer, Ira; Walker, Ryan W.; Loos, Ruth J.F.; Albu, Jeanine B.; Nadkarni, Girish N.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 33, No. 11, 2023, p. 2189-2198.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kittrell, HD, DiMenna, FJ, Arad, AD, Oh, W, Hofer, I, Walker, RW, Loos, RJF, Albu, JB & Nadkarni, GN 2023, 'Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation', Nutrition, Metabolism and Cardiovascular Diseases, vol. 33, no. 11, pp. 2189-2198. https://doi.org/10.1016/j.numecd.2023.07.014

APA

Kittrell, H. D., DiMenna, F. J., Arad, A. D., Oh, W., Hofer, I., Walker, R. W., Loos, R. J. F., Albu, J. B., & Nadkarni, G. N. (2023). Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation. Nutrition, Metabolism and Cardiovascular Diseases, 33(11), 2189-2198. https://doi.org/10.1016/j.numecd.2023.07.014

Vancouver

Kittrell HD, DiMenna FJ, Arad AD, Oh W, Hofer I, Walker RW et al. Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation. Nutrition, Metabolism and Cardiovascular Diseases. 2023;33(11):2189-2198. https://doi.org/10.1016/j.numecd.2023.07.014

Author

Kittrell, Hannah D. ; DiMenna, Fred J. ; Arad, Avigdor D. ; Oh, Wonsuk ; Hofer, Ira ; Walker, Ryan W. ; Loos, Ruth J.F. ; Albu, Jeanine B. ; Nadkarni, Girish N. / Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation. In: Nutrition, Metabolism and Cardiovascular Diseases. 2023 ; Vol. 33, No. 11. pp. 2189-2198.

Bibtex

@article{05b4b1a51a964165987a8e1cae2c2cf2,
title = "Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation",
abstract = "Background and aims: Ectopic lipid storage is implicated in type 2 diabetes pathogenesis; hence, exercise to deplete stores (i.e., at the intensity that allows for maximal rate of lipid oxidation; MLO) might be optimal for restoring metabolic health. This intensity (“Fatmax”) is estimated during incremental exercise (“Fatmax test”). However, in “the field” general recommendations exist regarding a range of percentages of maximal heart rate (HR) to elicit MLO. The degree to which this range is aligned with measured Fatmax has not been investigated. We compared measured HR at Fatmax, with maximal HR percentages within the typically recommended range in a sample of 26 individuals (Female: n = 11, European ancestry: n = 17). Methods and results: Subjects completed a modified Fatmax test with a 5-min warmup, followed by incremental stages starting at 15 W with work rate increased by 15 W every 5 min until termination criteria were reached. Pulmonary gas exchange was recorded and average values for V˙ o2 and V˙ co2 for the final minute of each stage were used to estimate substrate-oxidation rates. We modeled lipid-oxidation kinetics using a sinusoidal model and expressed MLO relative to peak V˙ o2 and HR. Bland-Altman analysis demonstrated lack of concordance between HR at Fatmax and at 50%, 70%, and 80% of age-predicted maximum with a mean difference of 23 b·min−1. Conclusion: Our results indicate that estimated “fat-burning” heart rate zones are inappropriate for prescribing exercise to elicit MLO and we recommend direct individual exercise lipid oxidation measurements to elicit these values.",
keywords = "Age-predicted maximum heart rate, Exercise, Insulin resistance, Lipid oxidation, Metabolic health",
author = "Kittrell, {Hannah D.} and DiMenna, {Fred J.} and Arad, {Avigdor D.} and Wonsuk Oh and Ira Hofer and Walker, {Ryan W.} and Loos, {Ruth J.F.} and Albu, {Jeanine B.} and Nadkarni, {Girish N.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University",
year = "2023",
doi = "10.1016/j.numecd.2023.07.014",
language = "English",
volume = "33",
pages = "2189--2198",
journal = "Nutrition, Metabolism & Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation

AU - Kittrell, Hannah D.

AU - DiMenna, Fred J.

AU - Arad, Avigdor D.

AU - Oh, Wonsuk

AU - Hofer, Ira

AU - Walker, Ryan W.

AU - Loos, Ruth J.F.

AU - Albu, Jeanine B.

AU - Nadkarni, Girish N.

N1 - Publisher Copyright: © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University

PY - 2023

Y1 - 2023

N2 - Background and aims: Ectopic lipid storage is implicated in type 2 diabetes pathogenesis; hence, exercise to deplete stores (i.e., at the intensity that allows for maximal rate of lipid oxidation; MLO) might be optimal for restoring metabolic health. This intensity (“Fatmax”) is estimated during incremental exercise (“Fatmax test”). However, in “the field” general recommendations exist regarding a range of percentages of maximal heart rate (HR) to elicit MLO. The degree to which this range is aligned with measured Fatmax has not been investigated. We compared measured HR at Fatmax, with maximal HR percentages within the typically recommended range in a sample of 26 individuals (Female: n = 11, European ancestry: n = 17). Methods and results: Subjects completed a modified Fatmax test with a 5-min warmup, followed by incremental stages starting at 15 W with work rate increased by 15 W every 5 min until termination criteria were reached. Pulmonary gas exchange was recorded and average values for V˙ o2 and V˙ co2 for the final minute of each stage were used to estimate substrate-oxidation rates. We modeled lipid-oxidation kinetics using a sinusoidal model and expressed MLO relative to peak V˙ o2 and HR. Bland-Altman analysis demonstrated lack of concordance between HR at Fatmax and at 50%, 70%, and 80% of age-predicted maximum with a mean difference of 23 b·min−1. Conclusion: Our results indicate that estimated “fat-burning” heart rate zones are inappropriate for prescribing exercise to elicit MLO and we recommend direct individual exercise lipid oxidation measurements to elicit these values.

AB - Background and aims: Ectopic lipid storage is implicated in type 2 diabetes pathogenesis; hence, exercise to deplete stores (i.e., at the intensity that allows for maximal rate of lipid oxidation; MLO) might be optimal for restoring metabolic health. This intensity (“Fatmax”) is estimated during incremental exercise (“Fatmax test”). However, in “the field” general recommendations exist regarding a range of percentages of maximal heart rate (HR) to elicit MLO. The degree to which this range is aligned with measured Fatmax has not been investigated. We compared measured HR at Fatmax, with maximal HR percentages within the typically recommended range in a sample of 26 individuals (Female: n = 11, European ancestry: n = 17). Methods and results: Subjects completed a modified Fatmax test with a 5-min warmup, followed by incremental stages starting at 15 W with work rate increased by 15 W every 5 min until termination criteria were reached. Pulmonary gas exchange was recorded and average values for V˙ o2 and V˙ co2 for the final minute of each stage were used to estimate substrate-oxidation rates. We modeled lipid-oxidation kinetics using a sinusoidal model and expressed MLO relative to peak V˙ o2 and HR. Bland-Altman analysis demonstrated lack of concordance between HR at Fatmax and at 50%, 70%, and 80% of age-predicted maximum with a mean difference of 23 b·min−1. Conclusion: Our results indicate that estimated “fat-burning” heart rate zones are inappropriate for prescribing exercise to elicit MLO and we recommend direct individual exercise lipid oxidation measurements to elicit these values.

KW - Age-predicted maximum heart rate

KW - Exercise

KW - Insulin resistance

KW - Lipid oxidation

KW - Metabolic health

U2 - 10.1016/j.numecd.2023.07.014

DO - 10.1016/j.numecd.2023.07.014

M3 - Journal article

C2 - 37567789

AN - SCOPUS:85168376748

VL - 33

SP - 2189

EP - 2198

JO - Nutrition, Metabolism & Cardiovascular Diseases

JF - Nutrition, Metabolism & Cardiovascular Diseases

SN - 0939-4753

IS - 11

ER -

ID: 365552220