Standard
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. / Kiryluk, Krzysztof; Sanchez-Rodriguez, Elena; Zhou, Xu Jie; Zanoni, Francesca; Liu, Lili; Mladkova, Nikol; Khan, Atlas; Marasa, Maddalena; Zhang, Jun Y.; Balderes, Olivia; Sanna-Cherchi, Simone; Bomback, Andrew S.; Canetta, Pietro A.; Appel, Gerald B.; Radhakrishnan, Jai; Trimarchi, Hernan; Sprangers, Ben; Cattran, Daniel C.; Reich, Heather; Pei, York; Ravani, Pietro; Galesic, Kresimir; Maixnerova, Dita; Tesar, Vladimir; Stengel, Benedicte; Metzger, Marie; Canaud, Guillaume; Maillard, Nicolas; Berthoux, Francois; Berthelot, Laureline; Pillebout, Evangeline; Monteiro, Renato; Nelson, Raoul; Wyatt, Robert J.; Smoyer, William; Mahan, John; Samhar, Al Akash; Hidalgo, Guillermo; Quiroga, Alejandro; Weng, Patricia; Sreedharan, Raji; Selewski, David; Davis, Keefe; Kallash, Mahmoud; Vasylyeva, Tetyana L.; Rheault, Michelle; Chishti, Aftab; Ranch, Daniel; Wenderfer, Scott E.; Samsonov, Dmitry; Claes, Donna J.; Akchurin, Oleh; Goumenos, Dimitrios; Stangou, Maria; Nagy, Judit; Kovacs, Tibor; Fiaccadori, Enrico; Amoroso, Antonio; Barlassina, Cristina; Cusi, Daniele; Del Vecchio, Lucia; Battaglia, Giovanni Giorgio; Bodria, Monica; Boer, Emanuela; Bono, Luisa; Boscutti, Giuliano; Caridi, Gianluca; Lugani, Francesca; Ghiggeri, Gian Marco; Coppo, Rosanna; Peruzzi, Licia; Esposito, Vittoria; Esposito, Ciro; Feriozzi, Sandro; Polci, Rosaria; Frasca, Giovanni; Galliani, Marco; Garozzo, Maurizio; Mitrotti, Adele; Gesualdo, Loreto; Granata, Simona; Zaza, Gianluigi; Londrino, Francesco; Magistroni, Riccardo; Pisani, Isabella; Magnano, Andrea; Marcantoni, Carmelita; Messa, Piergiorgio; Mignani, Renzo; Pani, Antonello; Ponticelli, Claudio; Roccatello, Dario; Salvadori, Maurizio; Salvi, Erica; Santoro, Domenico; Gembillo, Guido; Savoldi, Silvana; Spotti, Donatella; Zamboli, Pasquale; Izzi, Claudia; Alberici, Federico; Delbarba, Elisa; Florczak, Michał; Krata, Natalia; Mucha, Krzysztof; Pączek, Leszek; Niemczyk, Stanisław; Moszczuk, Barbara; Pańczyk-Tomaszewska, Malgorzata; Mizerska-Wasiak, Malgorzata; Perkowska-Ptasińska, Agnieszka; Bączkowska, Teresa; Durlik, Magdalena; Pawlaczyk, Krzysztof; Sikora, Przemyslaw; Zaniew, Marcin; Kaminska, Dorota; Krajewska, Magdalena; Kuzmiuk-Glembin, Izabella; Heleniak, Zbigniew; Bullo-Piontecka, Barbara; Liberek, Tomasz; Dębska-Slizien, Alicja; Hryszko, Tomasz; Materna-Kiryluk, Anna; Miklaszewska, Monika; Szczepańska, Maria; Dyga, Katarzyna; Machura, Edyta; Siniewicz-Luzeńczyk, Katarzyna; Pawlak-Bratkowska, Monika; Tkaczyk, Marcin; Runowski, Dariusz; Kwella, Norbert; Drożdż, Dorota; Habura, Ireneusz; Kronenberg, Florian; Prikhodina, Larisa; van Heel, David; Fontaine, Bertrand; Cotsapas, Chris; Wijmenga, Cisca; Franke, Andre; Annese, Vito; Gregersen, Peter K.; Parameswaran, Sreeja; Weirauch, Matthew; Kottyan, Leah; Harley, John B.; Suzuki, Hitoshi; Narita, Ichiei; Goto, Shin; Lee, Hajeong; Kim, Dong Ki; Kim, Yon Su; Park, Jin Ho; Cho, Be Long; Choi, Murim; Van Wijk, Ans; Huerta, Ana; Ars, Elisabet; Ballarin, Jose; Lundberg, Sigrid; Vogt, Bruno; Mani, Laila Yasmin; Caliskan, Yasar; Barratt, Jonathan; Abeygunaratne, Thilini; Kalra, Philip A.; Gale, Daniel P.; Panzer, Ulf; Rauen, Thomas; Floege, Jürgen; Schlosser, Pascal; Ekici, Arif B.; Eckardt, Kai Uwe; Chen, Nan; Xie, Jingyuan; Lifton, Richard P.; Loos, Ruth J.F.; Kenny, Eimear E.; Ionita-Laza, Iuliana; Köttgen, Anna; Julian, Bruce A.; Novak, Jan; Scolari, Francesco; Zhang, Hong; Gharavi, Ali G.
In:
Nature Genetics, Vol. 55, No. 7, 2023, p. 1091-1105.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Kiryluk, K, Sanchez-Rodriguez, E, Zhou, XJ, Zanoni, F, Liu, L, Mladkova, N, Khan, A, Marasa, M, Zhang, JY, Balderes, O, Sanna-Cherchi, S, Bomback, AS, Canetta, PA, Appel, GB, Radhakrishnan, J, Trimarchi, H, Sprangers, B, Cattran, DC, Reich, H, Pei, Y, Ravani, P, Galesic, K, Maixnerova, D, Tesar, V, Stengel, B, Metzger, M, Canaud, G, Maillard, N, Berthoux, F, Berthelot, L, Pillebout, E, Monteiro, R, Nelson, R, Wyatt, RJ, Smoyer, W, Mahan, J, Samhar, AA, Hidalgo, G, Quiroga, A, Weng, P, Sreedharan, R, Selewski, D, Davis, K, Kallash, M, Vasylyeva, TL, Rheault, M, Chishti, A, Ranch, D, Wenderfer, SE, Samsonov, D, Claes, DJ, Akchurin, O, Goumenos, D, Stangou, M, Nagy, J, Kovacs, T, Fiaccadori, E, Amoroso, A, Barlassina, C, Cusi, D, Del Vecchio, L, Battaglia, GG, Bodria, M, Boer, E, Bono, L, Boscutti, G, Caridi, G, Lugani, F, Ghiggeri, GM, Coppo, R, Peruzzi, L, Esposito, V, Esposito, C, Feriozzi, S, Polci, R, Frasca, G, Galliani, M, Garozzo, M, Mitrotti, A, Gesualdo, L, Granata, S, Zaza, G, Londrino, F, Magistroni, R, Pisani, I, Magnano, A, Marcantoni, C, Messa, P, Mignani, R, Pani, A, Ponticelli, C, Roccatello, D, Salvadori, M, Salvi, E, Santoro, D, Gembillo, G, Savoldi, S, Spotti, D, Zamboli, P, Izzi, C, Alberici, F, Delbarba, E, Florczak, M, Krata, N, Mucha, K, Pączek, L, Niemczyk, S, Moszczuk, B, Pańczyk-Tomaszewska, M, Mizerska-Wasiak, M, Perkowska-Ptasińska, A, Bączkowska, T, Durlik, M, Pawlaczyk, K, Sikora, P, Zaniew, M, Kaminska, D, Krajewska, M, Kuzmiuk-Glembin, I, Heleniak, Z, Bullo-Piontecka, B, Liberek, T, Dębska-Slizien, A, Hryszko, T, Materna-Kiryluk, A, Miklaszewska, M, Szczepańska, M, Dyga, K, Machura, E, Siniewicz-Luzeńczyk, K, Pawlak-Bratkowska, M, Tkaczyk, M, Runowski, D, Kwella, N, Drożdż, D, Habura, I, Kronenberg, F, Prikhodina, L, van Heel, D, Fontaine, B, Cotsapas, C, Wijmenga, C, Franke, A, Annese, V, Gregersen, PK, Parameswaran, S, Weirauch, M, Kottyan, L, Harley, JB, Suzuki, H, Narita, I, Goto, S, Lee, H, Kim, DK, Kim, YS, Park, JH, Cho, BL, Choi, M, Van Wijk, A, Huerta, A, Ars, E, Ballarin, J, Lundberg, S, Vogt, B, Mani, LY, Caliskan, Y, Barratt, J, Abeygunaratne, T, Kalra, PA, Gale, DP, Panzer, U, Rauen, T, Floege, J, Schlosser, P, Ekici, AB, Eckardt, KU, Chen, N, Xie, J, Lifton, RP
, Loos, RJF, Kenny, EE, Ionita-Laza, I, Köttgen, A, Julian, BA, Novak, J, Scolari, F, Zhang, H & Gharavi, AG 2023, '
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy',
Nature Genetics, vol. 55, no. 7, pp. 1091-1105.
https://doi.org/10.1038/s41588-023-01422-xAPA
Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X. J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., ... Gharavi, A. G. (2023).
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.
Nature Genetics,
55(7), 1091-1105.
https://doi.org/10.1038/s41588-023-01422-xVancouver
Kiryluk K, Sanchez-Rodriguez E, Zhou XJ, Zanoni F, Liu L, Mladkova N et al.
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.
Nature Genetics. 2023;55(7):1091-1105.
https://doi.org/10.1038/s41588-023-01422-xAuthor
Kiryluk, Krzysztof ; Sanchez-Rodriguez, Elena ; Zhou, Xu Jie ; Zanoni, Francesca ; Liu, Lili ; Mladkova, Nikol ; Khan, Atlas ; Marasa, Maddalena ; Zhang, Jun Y. ; Balderes, Olivia ; Sanna-Cherchi, Simone ; Bomback, Andrew S. ; Canetta, Pietro A. ; Appel, Gerald B. ; Radhakrishnan, Jai ; Trimarchi, Hernan ; Sprangers, Ben ; Cattran, Daniel C. ; Reich, Heather ; Pei, York ; Ravani, Pietro ; Galesic, Kresimir ; Maixnerova, Dita ; Tesar, Vladimir ; Stengel, Benedicte ; Metzger, Marie ; Canaud, Guillaume ; Maillard, Nicolas ; Berthoux, Francois ; Berthelot, Laureline ; Pillebout, Evangeline ; Monteiro, Renato ; Nelson, Raoul ; Wyatt, Robert J. ; Smoyer, William ; Mahan, John ; Samhar, Al Akash ; Hidalgo, Guillermo ; Quiroga, Alejandro ; Weng, Patricia ; Sreedharan, Raji ; Selewski, David ; Davis, Keefe ; Kallash, Mahmoud ; Vasylyeva, Tetyana L. ; Rheault, Michelle ; Chishti, Aftab ; Ranch, Daniel ; Wenderfer, Scott E. ; Samsonov, Dmitry ; Claes, Donna J. ; Akchurin, Oleh ; Goumenos, Dimitrios ; Stangou, Maria ; Nagy, Judit ; Kovacs, Tibor ; Fiaccadori, Enrico ; Amoroso, Antonio ; Barlassina, Cristina ; Cusi, Daniele ; Del Vecchio, Lucia ; Battaglia, Giovanni Giorgio ; Bodria, Monica ; Boer, Emanuela ; Bono, Luisa ; Boscutti, Giuliano ; Caridi, Gianluca ; Lugani, Francesca ; Ghiggeri, Gian Marco ; Coppo, Rosanna ; Peruzzi, Licia ; Esposito, Vittoria ; Esposito, Ciro ; Feriozzi, Sandro ; Polci, Rosaria ; Frasca, Giovanni ; Galliani, Marco ; Garozzo, Maurizio ; Mitrotti, Adele ; Gesualdo, Loreto ; Granata, Simona ; Zaza, Gianluigi ; Londrino, Francesco ; Magistroni, Riccardo ; Pisani, Isabella ; Magnano, Andrea ; Marcantoni, Carmelita ; Messa, Piergiorgio ; Mignani, Renzo ; Pani, Antonello ; Ponticelli, Claudio ; Roccatello, Dario ; Salvadori, Maurizio ; Salvi, Erica ; Santoro, Domenico ; Gembillo, Guido ; Savoldi, Silvana ; Spotti, Donatella ; Zamboli, Pasquale ; Izzi, Claudia ; Alberici, Federico ; Delbarba, Elisa ; Florczak, Michał ; Krata, Natalia ; Mucha, Krzysztof ; Pączek, Leszek ; Niemczyk, Stanisław ; Moszczuk, Barbara ; Pańczyk-Tomaszewska, Malgorzata ; Mizerska-Wasiak, Malgorzata ; Perkowska-Ptasińska, Agnieszka ; Bączkowska, Teresa ; Durlik, Magdalena ; Pawlaczyk, Krzysztof ; Sikora, Przemyslaw ; Zaniew, Marcin ; Kaminska, Dorota ; Krajewska, Magdalena ; Kuzmiuk-Glembin, Izabella ; Heleniak, Zbigniew ; Bullo-Piontecka, Barbara ; Liberek, Tomasz ; Dębska-Slizien, Alicja ; Hryszko, Tomasz ; Materna-Kiryluk, Anna ; Miklaszewska, Monika ; Szczepańska, Maria ; Dyga, Katarzyna ; Machura, Edyta ; Siniewicz-Luzeńczyk, Katarzyna ; Pawlak-Bratkowska, Monika ; Tkaczyk, Marcin ; Runowski, Dariusz ; Kwella, Norbert ; Drożdż, Dorota ; Habura, Ireneusz ; Kronenberg, Florian ; Prikhodina, Larisa ; van Heel, David ; Fontaine, Bertrand ; Cotsapas, Chris ; Wijmenga, Cisca ; Franke, Andre ; Annese, Vito ; Gregersen, Peter K. ; Parameswaran, Sreeja ; Weirauch, Matthew ; Kottyan, Leah ; Harley, John B. ; Suzuki, Hitoshi ; Narita, Ichiei ; Goto, Shin ; Lee, Hajeong ; Kim, Dong Ki ; Kim, Yon Su ; Park, Jin Ho ; Cho, Be Long ; Choi, Murim ; Van Wijk, Ans ; Huerta, Ana ; Ars, Elisabet ; Ballarin, Jose ; Lundberg, Sigrid ; Vogt, Bruno ; Mani, Laila Yasmin ; Caliskan, Yasar ; Barratt, Jonathan ; Abeygunaratne, Thilini ; Kalra, Philip A. ; Gale, Daniel P. ; Panzer, Ulf ; Rauen, Thomas ; Floege, Jürgen ; Schlosser, Pascal ; Ekici, Arif B. ; Eckardt, Kai Uwe ; Chen, Nan ; Xie, Jingyuan ; Lifton, Richard P. ; Loos, Ruth J.F. ; Kenny, Eimear E. ; Ionita-Laza, Iuliana ; Köttgen, Anna ; Julian, Bruce A. ; Novak, Jan ; Scolari, Francesco ; Zhang, Hong ; Gharavi, Ali G. / Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. In: Nature Genetics. 2023 ; Vol. 55, No. 7. pp. 1091-1105.
Bibtex
@article{349f9d2be050472286f1b9193c587264,
title = "Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy",
abstract = "IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls across 17 international cohorts. We defined 30 genome-wide significant risk loci explaining 11% of disease risk. A total of 16 loci were new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The risk loci were enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. We also observed a positive genetic correlation between IgAN and serum IgA levels. High polygenic score for IgAN was associated with earlier onset of kidney failure. In a comprehensive functional annotation analysis of candidate causal genes, we observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.",
author = "Krzysztof Kiryluk and Elena Sanchez-Rodriguez and Zhou, {Xu Jie} and Francesca Zanoni and Lili Liu and Nikol Mladkova and Atlas Khan and Maddalena Marasa and Zhang, {Jun Y.} and Olivia Balderes and Simone Sanna-Cherchi and Bomback, {Andrew S.} and Canetta, {Pietro A.} and Appel, {Gerald B.} and Jai Radhakrishnan and Hernan Trimarchi and Ben Sprangers and Cattran, {Daniel C.} and Heather Reich and York Pei and Pietro Ravani and Kresimir Galesic and Dita Maixnerova and Vladimir Tesar and Benedicte Stengel and Marie Metzger and Guillaume Canaud and Nicolas Maillard and Francois Berthoux and Laureline Berthelot and Evangeline Pillebout and Renato Monteiro and Raoul Nelson and Wyatt, {Robert J.} and William Smoyer and John Mahan and Samhar, {Al Akash} and Guillermo Hidalgo and Alejandro Quiroga and Patricia Weng and Raji Sreedharan and David Selewski and Keefe Davis and Mahmoud Kallash and Vasylyeva, {Tetyana L.} and Michelle Rheault and Aftab Chishti and Daniel Ranch and Wenderfer, {Scott E.} and Dmitry Samsonov and Claes, {Donna J.} and Oleh Akchurin and Dimitrios Goumenos and Maria Stangou and Judit Nagy and Tibor Kovacs and Enrico Fiaccadori and Antonio Amoroso and Cristina Barlassina and Daniele Cusi and {Del Vecchio}, Lucia and Battaglia, {Giovanni Giorgio} and Monica Bodria and Emanuela Boer and Luisa Bono and Giuliano Boscutti and Gianluca Caridi and Francesca Lugani and Ghiggeri, {Gian Marco} and Rosanna Coppo and Licia Peruzzi and Vittoria Esposito and Ciro Esposito and Sandro Feriozzi and Rosaria Polci and Giovanni Frasca and Marco Galliani and Maurizio Garozzo and Adele Mitrotti and Loreto Gesualdo and Simona Granata and Gianluigi Zaza and Francesco Londrino and Riccardo Magistroni and Isabella Pisani and Andrea Magnano and Carmelita Marcantoni and Piergiorgio Messa and Renzo Mignani and Antonello Pani and Claudio Ponticelli and Dario Roccatello and Maurizio Salvadori and Erica Salvi and Domenico Santoro and Guido Gembillo and Silvana Savoldi and Donatella Spotti and Pasquale Zamboli and Claudia Izzi and Federico Alberici and Elisa Delbarba and Micha{\l} Florczak and Natalia Krata and Krzysztof Mucha and Leszek P{\c a}czek and Stanis{\l}aw Niemczyk and Barbara Moszczuk and Malgorzata Pa{\'n}czyk-Tomaszewska and Malgorzata Mizerska-Wasiak and Agnieszka Perkowska-Ptasi{\'n}ska and Teresa B{\c a}czkowska and Magdalena Durlik and Krzysztof Pawlaczyk and Przemyslaw Sikora and Marcin Zaniew and Dorota Kaminska and Magdalena Krajewska and Izabella Kuzmiuk-Glembin and Zbigniew Heleniak and Barbara Bullo-Piontecka and Tomasz Liberek and Alicja D{\c e}bska-Slizien and Tomasz Hryszko and Anna Materna-Kiryluk and Monika Miklaszewska and Maria Szczepa{\'n}ska and Katarzyna Dyga and Edyta Machura and Katarzyna Siniewicz-Luze{\'n}czyk and Monika Pawlak-Bratkowska and Marcin Tkaczyk and Dariusz Runowski and Norbert Kwella and Dorota Dro{\.z}d{\.z} and Ireneusz Habura and Florian Kronenberg and Larisa Prikhodina and {van Heel}, David and Bertrand Fontaine and Chris Cotsapas and Cisca Wijmenga and Andre Franke and Vito Annese and Gregersen, {Peter K.} and Sreeja Parameswaran and Matthew Weirauch and Leah Kottyan and Harley, {John B.} and Hitoshi Suzuki and Ichiei Narita and Shin Goto and Hajeong Lee and Kim, {Dong Ki} and Kim, {Yon Su} and Park, {Jin Ho} and Cho, {Be Long} and Murim Choi and {Van Wijk}, Ans and Ana Huerta and Elisabet Ars and Jose Ballarin and Sigrid Lundberg and Bruno Vogt and Mani, {Laila Yasmin} and Yasar Caliskan and Jonathan Barratt and Thilini Abeygunaratne and Kalra, {Philip A.} and Gale, {Daniel P.} and Ulf Panzer and Thomas Rauen and J{\"u}rgen Floege and Pascal Schlosser and Ekici, {Arif B.} and Eckardt, {Kai Uwe} and Nan Chen and Jingyuan Xie and Lifton, {Richard P.} and Loos, {Ruth J.F.} and Kenny, {Eimear E.} and Iuliana Ionita-Laza and Anna K{\"o}ttgen and Julian, {Bruce A.} and Jan Novak and Francesco Scolari and Hong Zhang and Gharavi, {Ali G.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s41588-023-01422-x",
language = "English",
volume = "55",
pages = "1091--1105",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "7",
}
RIS
TY - JOUR
T1 - Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
AU - Kiryluk, Krzysztof
AU - Sanchez-Rodriguez, Elena
AU - Zhou, Xu Jie
AU - Zanoni, Francesca
AU - Liu, Lili
AU - Mladkova, Nikol
AU - Khan, Atlas
AU - Marasa, Maddalena
AU - Zhang, Jun Y.
AU - Balderes, Olivia
AU - Sanna-Cherchi, Simone
AU - Bomback, Andrew S.
AU - Canetta, Pietro A.
AU - Appel, Gerald B.
AU - Radhakrishnan, Jai
AU - Trimarchi, Hernan
AU - Sprangers, Ben
AU - Cattran, Daniel C.
AU - Reich, Heather
AU - Pei, York
AU - Ravani, Pietro
AU - Galesic, Kresimir
AU - Maixnerova, Dita
AU - Tesar, Vladimir
AU - Stengel, Benedicte
AU - Metzger, Marie
AU - Canaud, Guillaume
AU - Maillard, Nicolas
AU - Berthoux, Francois
AU - Berthelot, Laureline
AU - Pillebout, Evangeline
AU - Monteiro, Renato
AU - Nelson, Raoul
AU - Wyatt, Robert J.
AU - Smoyer, William
AU - Mahan, John
AU - Samhar, Al Akash
AU - Hidalgo, Guillermo
AU - Quiroga, Alejandro
AU - Weng, Patricia
AU - Sreedharan, Raji
AU - Selewski, David
AU - Davis, Keefe
AU - Kallash, Mahmoud
AU - Vasylyeva, Tetyana L.
AU - Rheault, Michelle
AU - Chishti, Aftab
AU - Ranch, Daniel
AU - Wenderfer, Scott E.
AU - Samsonov, Dmitry
AU - Claes, Donna J.
AU - Akchurin, Oleh
AU - Goumenos, Dimitrios
AU - Stangou, Maria
AU - Nagy, Judit
AU - Kovacs, Tibor
AU - Fiaccadori, Enrico
AU - Amoroso, Antonio
AU - Barlassina, Cristina
AU - Cusi, Daniele
AU - Del Vecchio, Lucia
AU - Battaglia, Giovanni Giorgio
AU - Bodria, Monica
AU - Boer, Emanuela
AU - Bono, Luisa
AU - Boscutti, Giuliano
AU - Caridi, Gianluca
AU - Lugani, Francesca
AU - Ghiggeri, Gian Marco
AU - Coppo, Rosanna
AU - Peruzzi, Licia
AU - Esposito, Vittoria
AU - Esposito, Ciro
AU - Feriozzi, Sandro
AU - Polci, Rosaria
AU - Frasca, Giovanni
AU - Galliani, Marco
AU - Garozzo, Maurizio
AU - Mitrotti, Adele
AU - Gesualdo, Loreto
AU - Granata, Simona
AU - Zaza, Gianluigi
AU - Londrino, Francesco
AU - Magistroni, Riccardo
AU - Pisani, Isabella
AU - Magnano, Andrea
AU - Marcantoni, Carmelita
AU - Messa, Piergiorgio
AU - Mignani, Renzo
AU - Pani, Antonello
AU - Ponticelli, Claudio
AU - Roccatello, Dario
AU - Salvadori, Maurizio
AU - Salvi, Erica
AU - Santoro, Domenico
AU - Gembillo, Guido
AU - Savoldi, Silvana
AU - Spotti, Donatella
AU - Zamboli, Pasquale
AU - Izzi, Claudia
AU - Alberici, Federico
AU - Delbarba, Elisa
AU - Florczak, Michał
AU - Krata, Natalia
AU - Mucha, Krzysztof
AU - Pączek, Leszek
AU - Niemczyk, Stanisław
AU - Moszczuk, Barbara
AU - Pańczyk-Tomaszewska, Malgorzata
AU - Mizerska-Wasiak, Malgorzata
AU - Perkowska-Ptasińska, Agnieszka
AU - Bączkowska, Teresa
AU - Durlik, Magdalena
AU - Pawlaczyk, Krzysztof
AU - Sikora, Przemyslaw
AU - Zaniew, Marcin
AU - Kaminska, Dorota
AU - Krajewska, Magdalena
AU - Kuzmiuk-Glembin, Izabella
AU - Heleniak, Zbigniew
AU - Bullo-Piontecka, Barbara
AU - Liberek, Tomasz
AU - Dębska-Slizien, Alicja
AU - Hryszko, Tomasz
AU - Materna-Kiryluk, Anna
AU - Miklaszewska, Monika
AU - Szczepańska, Maria
AU - Dyga, Katarzyna
AU - Machura, Edyta
AU - Siniewicz-Luzeńczyk, Katarzyna
AU - Pawlak-Bratkowska, Monika
AU - Tkaczyk, Marcin
AU - Runowski, Dariusz
AU - Kwella, Norbert
AU - Drożdż, Dorota
AU - Habura, Ireneusz
AU - Kronenberg, Florian
AU - Prikhodina, Larisa
AU - van Heel, David
AU - Fontaine, Bertrand
AU - Cotsapas, Chris
AU - Wijmenga, Cisca
AU - Franke, Andre
AU - Annese, Vito
AU - Gregersen, Peter K.
AU - Parameswaran, Sreeja
AU - Weirauch, Matthew
AU - Kottyan, Leah
AU - Harley, John B.
AU - Suzuki, Hitoshi
AU - Narita, Ichiei
AU - Goto, Shin
AU - Lee, Hajeong
AU - Kim, Dong Ki
AU - Kim, Yon Su
AU - Park, Jin Ho
AU - Cho, Be Long
AU - Choi, Murim
AU - Van Wijk, Ans
AU - Huerta, Ana
AU - Ars, Elisabet
AU - Ballarin, Jose
AU - Lundberg, Sigrid
AU - Vogt, Bruno
AU - Mani, Laila Yasmin
AU - Caliskan, Yasar
AU - Barratt, Jonathan
AU - Abeygunaratne, Thilini
AU - Kalra, Philip A.
AU - Gale, Daniel P.
AU - Panzer, Ulf
AU - Rauen, Thomas
AU - Floege, Jürgen
AU - Schlosser, Pascal
AU - Ekici, Arif B.
AU - Eckardt, Kai Uwe
AU - Chen, Nan
AU - Xie, Jingyuan
AU - Lifton, Richard P.
AU - Loos, Ruth J.F.
AU - Kenny, Eimear E.
AU - Ionita-Laza, Iuliana
AU - Köttgen, Anna
AU - Julian, Bruce A.
AU - Novak, Jan
AU - Scolari, Francesco
AU - Zhang, Hong
AU - Gharavi, Ali G.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023
Y1 - 2023
N2 - IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls across 17 international cohorts. We defined 30 genome-wide significant risk loci explaining 11% of disease risk. A total of 16 loci were new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The risk loci were enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. We also observed a positive genetic correlation between IgAN and serum IgA levels. High polygenic score for IgAN was associated with earlier onset of kidney failure. In a comprehensive functional annotation analysis of candidate causal genes, we observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.
AB - IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls across 17 international cohorts. We defined 30 genome-wide significant risk loci explaining 11% of disease risk. A total of 16 loci were new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The risk loci were enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. We also observed a positive genetic correlation between IgAN and serum IgA levels. High polygenic score for IgAN was associated with earlier onset of kidney failure. In a comprehensive functional annotation analysis of candidate causal genes, we observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.
U2 - 10.1038/s41588-023-01422-x
DO - 10.1038/s41588-023-01422-x
M3 - Journal article
C2 - 37337107
AN - SCOPUS:85162272555
VL - 55
SP - 1091
EP - 1105
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 7
ER -
