New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium
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New insights in the mechanisms of weight-loss maintenance : Summary from a Pennington symposium. / Flanagan, Emily W.; Spann, Redin; Berry, Sarah E.; Berthoud, Hans Rudolf; Broyles, Stephanie; Foster, Gary D.; Krakoff, Jonathan; Loos, Ruth J.F.; Lowe, Michael R.; Ostendorf, Danielle M.; Powell-Wiley, Tiffany M.; Redman, Leanne M.; Rosenbaum, Michael; Schauer, Philip R.; Seeley, Randy J.; Swinburn, Boyd A.; Hall, Kevin; Ravussin, Eric.
In: Obesity, Vol. 31, No. 12, 2023, p. 2895-2908.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - New insights in the mechanisms of weight-loss maintenance
T2 - Summary from a Pennington symposium
AU - Flanagan, Emily W.
AU - Spann, Redin
AU - Berry, Sarah E.
AU - Berthoud, Hans Rudolf
AU - Broyles, Stephanie
AU - Foster, Gary D.
AU - Krakoff, Jonathan
AU - Loos, Ruth J.F.
AU - Lowe, Michael R.
AU - Ostendorf, Danielle M.
AU - Powell-Wiley, Tiffany M.
AU - Redman, Leanne M.
AU - Rosenbaum, Michael
AU - Schauer, Philip R.
AU - Seeley, Randy J.
AU - Swinburn, Boyd A.
AU - Hall, Kevin
AU - Ravussin, Eric
N1 - Publisher Copyright: © 2023 The Obesity Society.
PY - 2023
Y1 - 2023
N2 - Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long-term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose of this Pennington Biomedical Scientific Symposium was to review and highlight the complex interplay between the physiological, behavioral, and environmental systems controlling energy intake and expenditure. Each of these contributions were further discussed in the context of weight-loss maintenance, and systems-level viewpoints were highlighted to interpret gaps in current approaches. The invited speakers built upon the science of obesity and weight loss to collectively propose future research directions that will aid in revealing the complicated mechanisms involved in the weight-reduced state.
AB - Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long-term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose of this Pennington Biomedical Scientific Symposium was to review and highlight the complex interplay between the physiological, behavioral, and environmental systems controlling energy intake and expenditure. Each of these contributions were further discussed in the context of weight-loss maintenance, and systems-level viewpoints were highlighted to interpret gaps in current approaches. The invited speakers built upon the science of obesity and weight loss to collectively propose future research directions that will aid in revealing the complicated mechanisms involved in the weight-reduced state.
U2 - 10.1002/oby.23905
DO - 10.1002/oby.23905
M3 - Journal article
C2 - 37845825
AN - SCOPUS:85174230734
VL - 31
SP - 2895
EP - 2908
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 12
ER -
ID: 371617111