TY - JOUR

T1 - PFAS Exposures and the Human Metabolome

T2 - A Systematic Review of Epidemiological Studies

AU - India-Aldana, Sandra

AU - Yao, Meizhen

AU - Midya, Vishal

AU - Colicino, Elena

AU - Chatzi, Leda

AU - Chu, Jaime

AU - Gennings, Chris

AU - Jones, Dean P.

AU - Loos, Ruth J.F.

AU - Setiawan, Veronica W.

AU - Smith, Mathew Ryan

AU - Walker, Ryan W.

AU - Barupal, Dinesh

AU - Walker, Douglas I.

AU - Valvi, Damaskini

N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

PY - 2023

Y1 - 2023

N2 - Purpose of Review: There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. Recent Findings: We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics. Summary: Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.

AB - Purpose of Review: There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. Recent Findings: We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics. Summary: Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.

KW - Endocrine-disrupting chemicals

KW - Human metabolome

KW - Metabolomics

KW - PFAS

KW - Systematic review

U2 - 10.1007/s40726-023-00269-4

DO - 10.1007/s40726-023-00269-4

M3 - Review

C2 - 37753190

AN - SCOPUS:85163666017

VL - 9

SP - 510

EP - 568

JO - Current Pollution Reports

JF - Current Pollution Reports

SN - 2198-6592

ER -