Standard
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. / Tobias, Deirdre K.; Merino, Jordi; Ahmad, Abrar; Aiken, Catherine; Benham, Jamie L.; Bodhini, Dhanasekaran; Clark, Amy L.; Colclough, Kevin; Corcoy, Rosa; Cromer, Sara J.; Duan, Daisy; Felton, Jamie L.; Francis, Ellen C.; Gillard, Pieter; Gingras, Véronique; Gaillard, Romy; Haider, Eram; Hughes, Alice; Ikle, Jennifer M.; Jacobsen, Laura M.; Kahkoska, Anna R.; Kettunen, Jarno L.T.; Kreienkamp, Raymond J.; Lim, Lee Ling; Männistö, Jonna M.E.; Massey, Robert; Mclennan, Niamh Maire; Miller, Rachel G.; Morieri, Mario Luca; Most, Jasper; Naylor, Rochelle N.; Ozkan, Bige; Patel, Kashyap Amratlal; Pilla, Scott J.; Prystupa, Katsiaryna; Raghavan, Sridharan; Rooney, Mary R.; Schön, Martin; Semnani-Azad, Zhila; Sevilla-Gonzalez, Magdalena; Svalastoga, Pernille; Takele, Wubet Worku; Tam, Claudia Ha ting; Thuesen, Anne Cathrine B.; Tosur, Mustafa; Wallace, Amelia S.; Wang, Caroline C.; Wong, Jessie J.; Yamamoto, Jennifer M.; Young, Katherine; Amouyal, Chloé; Andersen, Mette K.; Bonham, Maxine P.; Chen, Mingling; Cheng, Feifei; Chikowore, Tinashe; Chivers, Sian C.; Clemmensen, Christoffer; Dabelea, Dana; Dawed, Adem Y.; Deutsch, Aaron J.; Dickens, Laura T.; DiMeglio, Linda A.; Dudenhöffer-Pfeifer, Monika; Evans-Molina, Carmella; Fernández-Balsells, María Mercè; Fitipaldi, Hugo; Fitzpatrick, Stephanie L.; Gitelman, Stephen E.; Goodarzi, Mark O.; Grieger, Jessica A.; Guasch-Ferré, Marta; Habibi, Nahal; Hansen, Torben; Huang, Chuiguo; Harris-Kawano, Arianna; Ismail, Heba M.; Hoag, Benjamin; Johnson, Randi K.; Jones, Angus G.; Koivula, Robert W.; Leong, Aaron; Leung, Gloria K.W.; Libman, Ingrid M.; Liu, Kai; Long, S. Alice; Lowe, William L.; Morton, Robert W.; Motala, Ayesha A.; Onengut-Gumuscu, Suna; Pankow, James S.; Pathirana, Maleesa; Pazmino, Sofia; Perez, Dianna; Petrie, John R.; Powe, Camille E.; Quinteros, Alejandra; Jain, Rashmi; Ray, Debashree; Ried-Larsen, Mathias; Saeed, Zeb; Santhakumar, Vanessa; Kanbour, Sarah; Sarkar, Sudipa; Monaco, Gabriela S.F.; Scholtens, Denise M.; Selvin, Elizabeth; Sheu, Wayne Huey Herng; Speake, Cate; Stanislawski, Maggie A.; Steenackers, Nele; Steck, Andrea K.; Stefan, Norbert; Støy, Julie; Taylor, Rachael; Tye, Sok Cin; Ukke, Gebresilasea Gendisha; Urazbayeva, Marzhan; Van der Schueren, Bart; Vatier, Camille; Wentworth, John M.; Hannah, Wesley; White, Sara L.; Yu, Gechang; Zhang, Yingchai; Zhou, Shao J.; Beltrand, Jacques; Polak, Michel; Aukrust, Ingvild; de Franco, Elisa; Flanagan, Sarah E.; Maloney, Kristin A.; McGovern, Andrew; Molnes, Janne; Nakabuye, Mariam; Njølstad, Pål Rasmus; Pomares-Millan, Hugo; Provenzano, Michele; Saint-Martin, Cécile; Zhang, Cuilin; Zhu, Yeyi; Auh, Sungyoung; de Souza, Russell; Fawcett, Andrea J.; Gruber, Chandra; Mekonnen, Eskedar Getie; Mixter, Emily; Sherifali, Diana; Eckel, Robert H.; Nolan, John J.; Philipson, Louis H.; Brown, Rebecca J.; Billings, Liana K.; Boyle, Kristen; Costacou, Tina; Dennis, John M.; Florez, Jose C.; Gloyn, Anna L.; Gomez, Maria F.; Gottlieb, Peter A.; Greeley, Siri Atma W.; Griffin, Kurt; Hattersley, Andrew T.; Hirsch, Irl B.; Hivert, Marie France; Hood, Korey K.; Josefson, Jami L.; Kwak, Soo Heon; Laffel, Lori M.; Lim, Siew S.; Loos, Ruth J.F.; Ma, Ronald C.W.; Mathieu, Chantal; Mathioudakis, Nestoras; Meigs, James B.; Misra, Shivani; Mohan, Viswanathan; Murphy, Rinki; Oram, Richard; Owen, Katharine R.; Ozanne, Susan E.; Pearson, Ewan R.; Perng, Wei; Pollin, Toni I.; Pop-Busui, Rodica; Pratley, Richard E.; Redman, Leanne M.; Redondo, Maria J.; Reynolds, Rebecca M.; Semple, Robert K.; Sherr, Jennifer L.; Sims, Emily K.; Sweeting, Arianne; Tuomi, Tiinamaija; Udler, Miriam S.; Vesco, Kimberly K.; Vilsbøll, Tina; Wagner, Robert; Rich, Stephen S.; Franks, Paul W.
In:
Nature Medicine, Vol. 29, No. 10, 2023, p. 2438-2457.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Tobias, DK
, Merino, J, Ahmad, A, Aiken, C, Benham, JL, Bodhini, D, Clark, AL, Colclough, K, Corcoy, R, Cromer, SJ, Duan, D, Felton, JL, Francis, EC, Gillard, P, Gingras, V, Gaillard, R, Haider, E, Hughes, A, Ikle, JM, Jacobsen, LM, Kahkoska, AR, Kettunen, JLT, Kreienkamp, RJ, Lim, LL, Männistö, JME, Massey, R, Mclennan, NM, Miller, RG, Morieri, ML, Most, J, Naylor, RN, Ozkan, B, Patel, KA, Pilla, SJ, Prystupa, K, Raghavan, S, Rooney, MR, Schön, M, Semnani-Azad, Z, Sevilla-Gonzalez, M, Svalastoga, P, Takele, WW, Tam, CHT
, Thuesen, ACB, Tosur, M, Wallace, AS, Wang, CC, Wong, JJ, Yamamoto, JM, Young, K, Amouyal, C
, Andersen, MK, Bonham, MP, Chen, M, Cheng, F, Chikowore, T, Chivers, SC
, Clemmensen, C, Dabelea, D, Dawed, AY, Deutsch, AJ, Dickens, LT, DiMeglio, LA, Dudenhöffer-Pfeifer, M, Evans-Molina, C, Fernández-Balsells, MM, Fitipaldi, H, Fitzpatrick, SL, Gitelman, SE, Goodarzi, MO, Grieger, JA
, Guasch-Ferré, M, Habibi, N
, Hansen, T, Huang, C, Harris-Kawano, A, Ismail, HM, Hoag, B, Johnson, RK, Jones, AG, Koivula, RW, Leong, A, Leung, GKW, Libman, IM, Liu, K, Long, SA, Lowe, WL, Morton, RW, Motala, AA, Onengut-Gumuscu, S, Pankow, JS, Pathirana, M, Pazmino, S, Perez, D, Petrie, JR, Powe, CE, Quinteros, A, Jain, R, Ray, D, Ried-Larsen, M, Saeed, Z, Santhakumar, V, Kanbour, S, Sarkar, S, Monaco, GSF, Scholtens, DM, Selvin, E, Sheu, WHH, Speake, C, Stanislawski, MA, Steenackers, N, Steck, AK, Stefan, N, Støy, J, Taylor, R, Tye, SC, Ukke, GG, Urazbayeva, M, Van der Schueren, B, Vatier, C, Wentworth, JM, Hannah, W, White, SL, Yu, G, Zhang, Y, Zhou, SJ, Beltrand, J, Polak, M, Aukrust, I, de Franco, E, Flanagan, SE, Maloney, KA, McGovern, A, Molnes, J
, Nakabuye, M, Njølstad, PR, Pomares-Millan, H, Provenzano, M, Saint-Martin, C, Zhang, C, Zhu, Y, Auh, S, de Souza, R, Fawcett, AJ, Gruber, C, Mekonnen, EG, Mixter, E, Sherifali, D, Eckel, RH, Nolan, JJ, Philipson, LH, Brown, RJ, Billings, LK, Boyle, K, Costacou, T, Dennis, JM, Florez, JC, Gloyn, AL, Gomez, MF, Gottlieb, PA, Greeley, SAW, Griffin, K, Hattersley, AT, Hirsch, IB, Hivert, MF, Hood, KK, Josefson, JL, Kwak, SH, Laffel, LM, Lim, SS
, Loos, RJF, Ma, RCW, Mathieu, C, Mathioudakis, N, Meigs, JB, Misra, S, Mohan, V, Murphy, R, Oram, R, Owen, KR, Ozanne, SE, Pearson, ER, Perng, W, Pollin, TI, Pop-Busui, R, Pratley, RE, Redman, LM, Redondo, MJ, Reynolds, RM, Semple, RK, Sherr, JL, Sims, EK, Sweeting, A, Tuomi, T, Udler, MS, Vesco, KK
, Vilsbøll, T, Wagner, R, Rich, SS & Franks, PW 2023, '
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine',
Nature Medicine, vol. 29, no. 10, pp. 2438-2457.
https://doi.org/10.1038/s41591-023-02502-5
APA
Tobias, D. K.
, Merino, J., Ahmad, A., Aiken, C., Benham, J. L., Bodhini, D., Clark, A. L., Colclough, K., Corcoy, R., Cromer, S. J., Duan, D., Felton, J. L., Francis, E. C., Gillard, P., Gingras, V., Gaillard, R., Haider, E., Hughes, A., Ikle, J. M., ... Franks, P. W. (2023).
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Nature Medicine,
29(10), 2438-2457.
https://doi.org/10.1038/s41591-023-02502-5
Vancouver
Tobias DK
, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D et al.
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Nature Medicine. 2023;29(10):2438-2457.
https://doi.org/10.1038/s41591-023-02502-5
Author
Tobias, Deirdre K. ; Merino, Jordi ; Ahmad, Abrar ; Aiken, Catherine ; Benham, Jamie L. ; Bodhini, Dhanasekaran ; Clark, Amy L. ; Colclough, Kevin ; Corcoy, Rosa ; Cromer, Sara J. ; Duan, Daisy ; Felton, Jamie L. ; Francis, Ellen C. ; Gillard, Pieter ; Gingras, Véronique ; Gaillard, Romy ; Haider, Eram ; Hughes, Alice ; Ikle, Jennifer M. ; Jacobsen, Laura M. ; Kahkoska, Anna R. ; Kettunen, Jarno L.T. ; Kreienkamp, Raymond J. ; Lim, Lee Ling ; Männistö, Jonna M.E. ; Massey, Robert ; Mclennan, Niamh Maire ; Miller, Rachel G. ; Morieri, Mario Luca ; Most, Jasper ; Naylor, Rochelle N. ; Ozkan, Bige ; Patel, Kashyap Amratlal ; Pilla, Scott J. ; Prystupa, Katsiaryna ; Raghavan, Sridharan ; Rooney, Mary R. ; Schön, Martin ; Semnani-Azad, Zhila ; Sevilla-Gonzalez, Magdalena ; Svalastoga, Pernille ; Takele, Wubet Worku ; Tam, Claudia Ha ting ; Thuesen, Anne Cathrine B. ; Tosur, Mustafa ; Wallace, Amelia S. ; Wang, Caroline C. ; Wong, Jessie J. ; Yamamoto, Jennifer M. ; Young, Katherine ; Amouyal, Chloé ; Andersen, Mette K. ; Bonham, Maxine P. ; Chen, Mingling ; Cheng, Feifei ; Chikowore, Tinashe ; Chivers, Sian C. ; Clemmensen, Christoffer ; Dabelea, Dana ; Dawed, Adem Y. ; Deutsch, Aaron J. ; Dickens, Laura T. ; DiMeglio, Linda A. ; Dudenhöffer-Pfeifer, Monika ; Evans-Molina, Carmella ; Fernández-Balsells, María Mercè ; Fitipaldi, Hugo ; Fitzpatrick, Stephanie L. ; Gitelman, Stephen E. ; Goodarzi, Mark O. ; Grieger, Jessica A. ; Guasch-Ferré, Marta ; Habibi, Nahal ; Hansen, Torben ; Huang, Chuiguo ; Harris-Kawano, Arianna ; Ismail, Heba M. ; Hoag, Benjamin ; Johnson, Randi K. ; Jones, Angus G. ; Koivula, Robert W. ; Leong, Aaron ; Leung, Gloria K.W. ; Libman, Ingrid M. ; Liu, Kai ; Long, S. Alice ; Lowe, William L. ; Morton, Robert W. ; Motala, Ayesha A. ; Onengut-Gumuscu, Suna ; Pankow, James S. ; Pathirana, Maleesa ; Pazmino, Sofia ; Perez, Dianna ; Petrie, John R. ; Powe, Camille E. ; Quinteros, Alejandra ; Jain, Rashmi ; Ray, Debashree ; Ried-Larsen, Mathias ; Saeed, Zeb ; Santhakumar, Vanessa ; Kanbour, Sarah ; Sarkar, Sudipa ; Monaco, Gabriela S.F. ; Scholtens, Denise M. ; Selvin, Elizabeth ; Sheu, Wayne Huey Herng ; Speake, Cate ; Stanislawski, Maggie A. ; Steenackers, Nele ; Steck, Andrea K. ; Stefan, Norbert ; Støy, Julie ; Taylor, Rachael ; Tye, Sok Cin ; Ukke, Gebresilasea Gendisha ; Urazbayeva, Marzhan ; Van der Schueren, Bart ; Vatier, Camille ; Wentworth, John M. ; Hannah, Wesley ; White, Sara L. ; Yu, Gechang ; Zhang, Yingchai ; Zhou, Shao J. ; Beltrand, Jacques ; Polak, Michel ; Aukrust, Ingvild ; de Franco, Elisa ; Flanagan, Sarah E. ; Maloney, Kristin A. ; McGovern, Andrew ; Molnes, Janne ; Nakabuye, Mariam ; Njølstad, Pål Rasmus ; Pomares-Millan, Hugo ; Provenzano, Michele ; Saint-Martin, Cécile ; Zhang, Cuilin ; Zhu, Yeyi ; Auh, Sungyoung ; de Souza, Russell ; Fawcett, Andrea J. ; Gruber, Chandra ; Mekonnen, Eskedar Getie ; Mixter, Emily ; Sherifali, Diana ; Eckel, Robert H. ; Nolan, John J. ; Philipson, Louis H. ; Brown, Rebecca J. ; Billings, Liana K. ; Boyle, Kristen ; Costacou, Tina ; Dennis, John M. ; Florez, Jose C. ; Gloyn, Anna L. ; Gomez, Maria F. ; Gottlieb, Peter A. ; Greeley, Siri Atma W. ; Griffin, Kurt ; Hattersley, Andrew T. ; Hirsch, Irl B. ; Hivert, Marie France ; Hood, Korey K. ; Josefson, Jami L. ; Kwak, Soo Heon ; Laffel, Lori M. ; Lim, Siew S. ; Loos, Ruth J.F. ; Ma, Ronald C.W. ; Mathieu, Chantal ; Mathioudakis, Nestoras ; Meigs, James B. ; Misra, Shivani ; Mohan, Viswanathan ; Murphy, Rinki ; Oram, Richard ; Owen, Katharine R. ; Ozanne, Susan E. ; Pearson, Ewan R. ; Perng, Wei ; Pollin, Toni I. ; Pop-Busui, Rodica ; Pratley, Richard E. ; Redman, Leanne M. ; Redondo, Maria J. ; Reynolds, Rebecca M. ; Semple, Robert K. ; Sherr, Jennifer L. ; Sims, Emily K. ; Sweeting, Arianne ; Tuomi, Tiinamaija ; Udler, Miriam S. ; Vesco, Kimberly K. ; Vilsbøll, Tina ; Wagner, Robert ; Rich, Stephen S. ; Franks, Paul W. / Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. In: Nature Medicine. 2023 ; Vol. 29, No. 10. pp. 2438-2457.
Bibtex
@article{e09a129256774346ba39df67b8e3b0bd,
title = "Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine",
abstract = "Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.",
author = "Tobias, {Deirdre K.} and Jordi Merino and Abrar Ahmad and Catherine Aiken and Benham, {Jamie L.} and Dhanasekaran Bodhini and Clark, {Amy L.} and Kevin Colclough and Rosa Corcoy and Cromer, {Sara J.} and Daisy Duan and Felton, {Jamie L.} and Francis, {Ellen C.} and Pieter Gillard and V{\'e}ronique Gingras and Romy Gaillard and Eram Haider and Alice Hughes and Ikle, {Jennifer M.} and Jacobsen, {Laura M.} and Kahkoska, {Anna R.} and Kettunen, {Jarno L.T.} and Kreienkamp, {Raymond J.} and Lim, {Lee Ling} and M{\"a}nnist{\"o}, {Jonna M.E.} and Robert Massey and Mclennan, {Niamh Maire} and Miller, {Rachel G.} and Morieri, {Mario Luca} and Jasper Most and Naylor, {Rochelle N.} and Bige Ozkan and Patel, {Kashyap Amratlal} and Pilla, {Scott J.} and Katsiaryna Prystupa and Sridharan Raghavan and Rooney, {Mary R.} and Martin Sch{\"o}n and Zhila Semnani-Azad and Magdalena Sevilla-Gonzalez and Pernille Svalastoga and Takele, {Wubet Worku} and Tam, {Claudia Ha ting} and Thuesen, {Anne Cathrine B.} and Mustafa Tosur and Wallace, {Amelia S.} and Wang, {Caroline C.} and Wong, {Jessie J.} and Yamamoto, {Jennifer M.} and Katherine Young and Chlo{\'e} Amouyal and Andersen, {Mette K.} and Bonham, {Maxine P.} and Mingling Chen and Feifei Cheng and Tinashe Chikowore and Chivers, {Sian C.} and Christoffer Clemmensen and Dana Dabelea and Dawed, {Adem Y.} and Deutsch, {Aaron J.} and Dickens, {Laura T.} and DiMeglio, {Linda A.} and Monika Dudenh{\"o}ffer-Pfeifer and Carmella Evans-Molina and Fern{\'a}ndez-Balsells, {Mar{\'i}a Merc{\`e}} and Hugo Fitipaldi and Fitzpatrick, {Stephanie L.} and Gitelman, {Stephen E.} and Goodarzi, {Mark O.} and Grieger, {Jessica A.} and Marta Guasch-Ferr{\'e} and Nahal Habibi and Torben Hansen and Chuiguo Huang and Arianna Harris-Kawano and Ismail, {Heba M.} and Benjamin Hoag and Johnson, {Randi K.} and Jones, {Angus G.} and Koivula, {Robert W.} and Aaron Leong and Leung, {Gloria K.W.} and Libman, {Ingrid M.} and Kai Liu and Long, {S. Alice} and Lowe, {William L.} and Morton, {Robert W.} and Motala, {Ayesha A.} and Suna Onengut-Gumuscu and Pankow, {James S.} and Maleesa Pathirana and Sofia Pazmino and Dianna Perez and Petrie, {John R.} and Powe, {Camille E.} and Alejandra Quinteros and Rashmi Jain and Debashree Ray and Mathias Ried-Larsen and Zeb Saeed and Vanessa Santhakumar and Sarah Kanbour and Sudipa Sarkar and Monaco, {Gabriela S.F.} and Scholtens, {Denise M.} and Elizabeth Selvin and Sheu, {Wayne Huey Herng} and Cate Speake and Stanislawski, {Maggie A.} and Nele Steenackers and Steck, {Andrea K.} and Norbert Stefan and Julie St{\o}y and Rachael Taylor and Tye, {Sok Cin} and Ukke, {Gebresilasea Gendisha} and Marzhan Urazbayeva and {Van der Schueren}, Bart and Camille Vatier and Wentworth, {John M.} and Wesley Hannah and White, {Sara L.} and Gechang Yu and Yingchai Zhang and Zhou, {Shao J.} and Jacques Beltrand and Michel Polak and Ingvild Aukrust and {de Franco}, Elisa and Flanagan, {Sarah E.} and Maloney, {Kristin A.} and Andrew McGovern and Janne Molnes and Mariam Nakabuye and Nj{\o}lstad, {P{\aa}l Rasmus} and Hugo Pomares-Millan and Michele Provenzano and C{\'e}cile Saint-Martin and Cuilin Zhang and Yeyi Zhu and Sungyoung Auh and {de Souza}, Russell and Fawcett, {Andrea J.} and Chandra Gruber and Mekonnen, {Eskedar Getie} and Emily Mixter and Diana Sherifali and Eckel, {Robert H.} and Nolan, {John J.} and Philipson, {Louis H.} and Brown, {Rebecca J.} and Billings, {Liana K.} and Kristen Boyle and Tina Costacou and Dennis, {John M.} and Florez, {Jose C.} and Gloyn, {Anna L.} and Gomez, {Maria F.} and Gottlieb, {Peter A.} and Greeley, {Siri Atma W.} and Kurt Griffin and Hattersley, {Andrew T.} and Hirsch, {Irl B.} and Hivert, {Marie France} and Hood, {Korey K.} and Josefson, {Jami L.} and Kwak, {Soo Heon} and Laffel, {Lori M.} and Lim, {Siew S.} and Loos, {Ruth J.F.} and Ma, {Ronald C.W.} and Chantal Mathieu and Nestoras Mathioudakis and Meigs, {James B.} and Shivani Misra and Viswanathan Mohan and Rinki Murphy and Richard Oram and Owen, {Katharine R.} and Ozanne, {Susan E.} and Pearson, {Ewan R.} and Wei Perng and Pollin, {Toni I.} and Rodica Pop-Busui and Pratley, {Richard E.} and Redman, {Leanne M.} and Redondo, {Maria J.} and Reynolds, {Rebecca M.} and Semple, {Robert K.} and Sherr, {Jennifer L.} and Sims, {Emily K.} and Arianne Sweeting and Tiinamaija Tuomi and Udler, {Miriam S.} and Vesco, {Kimberly K.} and Tina Vilsb{\o}ll and Robert Wagner and Rich, {Stephen S.} and Franks, {Paul W.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s41591-023-02502-5",
language = "English",
volume = "29",
pages = "2438--2457",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "nature publishing group",
number = "10",
}
RIS
TY - JOUR
T1 - Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
AU - Tobias, Deirdre K.
AU - Merino, Jordi
AU - Ahmad, Abrar
AU - Aiken, Catherine
AU - Benham, Jamie L.
AU - Bodhini, Dhanasekaran
AU - Clark, Amy L.
AU - Colclough, Kevin
AU - Corcoy, Rosa
AU - Cromer, Sara J.
AU - Duan, Daisy
AU - Felton, Jamie L.
AU - Francis, Ellen C.
AU - Gillard, Pieter
AU - Gingras, Véronique
AU - Gaillard, Romy
AU - Haider, Eram
AU - Hughes, Alice
AU - Ikle, Jennifer M.
AU - Jacobsen, Laura M.
AU - Kahkoska, Anna R.
AU - Kettunen, Jarno L.T.
AU - Kreienkamp, Raymond J.
AU - Lim, Lee Ling
AU - Männistö, Jonna M.E.
AU - Massey, Robert
AU - Mclennan, Niamh Maire
AU - Miller, Rachel G.
AU - Morieri, Mario Luca
AU - Most, Jasper
AU - Naylor, Rochelle N.
AU - Ozkan, Bige
AU - Patel, Kashyap Amratlal
AU - Pilla, Scott J.
AU - Prystupa, Katsiaryna
AU - Raghavan, Sridharan
AU - Rooney, Mary R.
AU - Schön, Martin
AU - Semnani-Azad, Zhila
AU - Sevilla-Gonzalez, Magdalena
AU - Svalastoga, Pernille
AU - Takele, Wubet Worku
AU - Tam, Claudia Ha ting
AU - Thuesen, Anne Cathrine B.
AU - Tosur, Mustafa
AU - Wallace, Amelia S.
AU - Wang, Caroline C.
AU - Wong, Jessie J.
AU - Yamamoto, Jennifer M.
AU - Young, Katherine
AU - Amouyal, Chloé
AU - Andersen, Mette K.
AU - Bonham, Maxine P.
AU - Chen, Mingling
AU - Cheng, Feifei
AU - Chikowore, Tinashe
AU - Chivers, Sian C.
AU - Clemmensen, Christoffer
AU - Dabelea, Dana
AU - Dawed, Adem Y.
AU - Deutsch, Aaron J.
AU - Dickens, Laura T.
AU - DiMeglio, Linda A.
AU - Dudenhöffer-Pfeifer, Monika
AU - Evans-Molina, Carmella
AU - Fernández-Balsells, María Mercè
AU - Fitipaldi, Hugo
AU - Fitzpatrick, Stephanie L.
AU - Gitelman, Stephen E.
AU - Goodarzi, Mark O.
AU - Grieger, Jessica A.
AU - Guasch-Ferré, Marta
AU - Habibi, Nahal
AU - Hansen, Torben
AU - Huang, Chuiguo
AU - Harris-Kawano, Arianna
AU - Ismail, Heba M.
AU - Hoag, Benjamin
AU - Johnson, Randi K.
AU - Jones, Angus G.
AU - Koivula, Robert W.
AU - Leong, Aaron
AU - Leung, Gloria K.W.
AU - Libman, Ingrid M.
AU - Liu, Kai
AU - Long, S. Alice
AU - Lowe, William L.
AU - Morton, Robert W.
AU - Motala, Ayesha A.
AU - Onengut-Gumuscu, Suna
AU - Pankow, James S.
AU - Pathirana, Maleesa
AU - Pazmino, Sofia
AU - Perez, Dianna
AU - Petrie, John R.
AU - Powe, Camille E.
AU - Quinteros, Alejandra
AU - Jain, Rashmi
AU - Ray, Debashree
AU - Ried-Larsen, Mathias
AU - Saeed, Zeb
AU - Santhakumar, Vanessa
AU - Kanbour, Sarah
AU - Sarkar, Sudipa
AU - Monaco, Gabriela S.F.
AU - Scholtens, Denise M.
AU - Selvin, Elizabeth
AU - Sheu, Wayne Huey Herng
AU - Speake, Cate
AU - Stanislawski, Maggie A.
AU - Steenackers, Nele
AU - Steck, Andrea K.
AU - Stefan, Norbert
AU - Støy, Julie
AU - Taylor, Rachael
AU - Tye, Sok Cin
AU - Ukke, Gebresilasea Gendisha
AU - Urazbayeva, Marzhan
AU - Van der Schueren, Bart
AU - Vatier, Camille
AU - Wentworth, John M.
AU - Hannah, Wesley
AU - White, Sara L.
AU - Yu, Gechang
AU - Zhang, Yingchai
AU - Zhou, Shao J.
AU - Beltrand, Jacques
AU - Polak, Michel
AU - Aukrust, Ingvild
AU - de Franco, Elisa
AU - Flanagan, Sarah E.
AU - Maloney, Kristin A.
AU - McGovern, Andrew
AU - Molnes, Janne
AU - Nakabuye, Mariam
AU - Njølstad, Pål Rasmus
AU - Pomares-Millan, Hugo
AU - Provenzano, Michele
AU - Saint-Martin, Cécile
AU - Zhang, Cuilin
AU - Zhu, Yeyi
AU - Auh, Sungyoung
AU - de Souza, Russell
AU - Fawcett, Andrea J.
AU - Gruber, Chandra
AU - Mekonnen, Eskedar Getie
AU - Mixter, Emily
AU - Sherifali, Diana
AU - Eckel, Robert H.
AU - Nolan, John J.
AU - Philipson, Louis H.
AU - Brown, Rebecca J.
AU - Billings, Liana K.
AU - Boyle, Kristen
AU - Costacou, Tina
AU - Dennis, John M.
AU - Florez, Jose C.
AU - Gloyn, Anna L.
AU - Gomez, Maria F.
AU - Gottlieb, Peter A.
AU - Greeley, Siri Atma W.
AU - Griffin, Kurt
AU - Hattersley, Andrew T.
AU - Hirsch, Irl B.
AU - Hivert, Marie France
AU - Hood, Korey K.
AU - Josefson, Jami L.
AU - Kwak, Soo Heon
AU - Laffel, Lori M.
AU - Lim, Siew S.
AU - Loos, Ruth J.F.
AU - Ma, Ronald C.W.
AU - Mathieu, Chantal
AU - Mathioudakis, Nestoras
AU - Meigs, James B.
AU - Misra, Shivani
AU - Mohan, Viswanathan
AU - Murphy, Rinki
AU - Oram, Richard
AU - Owen, Katharine R.
AU - Ozanne, Susan E.
AU - Pearson, Ewan R.
AU - Perng, Wei
AU - Pollin, Toni I.
AU - Pop-Busui, Rodica
AU - Pratley, Richard E.
AU - Redman, Leanne M.
AU - Redondo, Maria J.
AU - Reynolds, Rebecca M.
AU - Semple, Robert K.
AU - Sherr, Jennifer L.
AU - Sims, Emily K.
AU - Sweeting, Arianne
AU - Tuomi, Tiinamaija
AU - Udler, Miriam S.
AU - Vesco, Kimberly K.
AU - Vilsbøll, Tina
AU - Wagner, Robert
AU - Rich, Stephen S.
AU - Franks, Paul W.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023
Y1 - 2023
N2 - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
AB - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
U2 - 10.1038/s41591-023-02502-5
DO - 10.1038/s41591-023-02502-5
M3 - Journal article
C2 - 37794253
AN - SCOPUS:85173437266
VL - 29
SP - 2438
EP - 2457
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 10
ER -