The genetics of obesity: from discovery to biology
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The genetics of obesity : from discovery to biology. / Loos, Ruth J.F.; Yeo, Giles S.H.
In: Nature Reviews Genetics, Vol. 23, 2021, p. 120-133.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The genetics of obesity
T2 - from discovery to biology
AU - Loos, Ruth J.F.
AU - Yeo, Giles S.H.
N1 - Publisher Copyright: © 2021, Springer Nature Limited.
PY - 2021
Y1 - 2021
N2 - The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
AB - The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
U2 - 10.1038/s41576-021-00414-z
DO - 10.1038/s41576-021-00414-z
M3 - Review
C2 - 34556834
AN - SCOPUS:85115429429
VL - 23
SP - 120
EP - 133
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
SN - 1471-0056
ER -
ID: 281163638