Loos Group

  1. 2022
  2. Published

    A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Zhao, J. H., Aadahl, Mette, Bork-Jensen, J., Møllehave, L. T., Liu, J., Wang, J., drb459, drb459, Jackson, R. D., Kovacs, P., Pedersen, Oluf Borbye, Hansen, Torben, Lind, L., Loos, Ruth, Christensen, K., Linneberg, Allan René, Grarup, Niels, Dantoft, T. M., Karpe, F., Wei, W. Q., Sun, Y. V., Million Veterans Program, M. V. P. & Global Lipids Genetics Consortium, G. L. G. C., 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A saturated map of common genetic variants associated with human height

    Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S., Ferreira, T., Highland, H. H., Ji, Y., Karaderi, Tugce, Lin, K., Lull, K., Malden, D. E., Lepola, Mette Andersen, Appadurai, V., Bork-Jensen, J., Burgdorf, Kristoffer Sølvsten, Hansen, Thomas Folkmann, Jonsson, Anna Elisabet, Jorgensen, T., Liu, Jun, Mollehave, L. T., Smit, Roelof Adriaan Johan, Zhao, J., Bisgaard, H., Bønnelykke, Klaus, Dantoft, T. M., Grarup, Niels, Hansen, Torben, Jackson, R. D., Karpe, F., Kovacs, P., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Werge, Thomas, Sun, Y., Loos, Ruth, Winkler, T. W., 23andMe Res Team, 2. R. T., VA Million Vet Program, V. M. V. P., DiscovEHR DiscovEHR MyCode Communi, D. D. M. C., eEMERGE Elect Med Records Genomics, E. E. M. R. G., LifeLines Cohort Study, L. C. S., PRACTICAL consortium, P. C. & Understanding Soc Sci Grp, U. S. S. G., 2022, In: Nature. 610, p. 704–712

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium

    Fernández-Rhodes, L., Graff, M., Buchanan, V. L., Justice, A. E., Highland, H. M., Guo, X., Zhu, W., Chen, H. H., Young, K. L., Adhikari, K., Palmer, N. D., Below, J. E., Bradfield, J., Pereira, A. C., Glover, L. S., Kim, D., Lilly, A. G., Shrestha, P., Thomas, A. G., Zhang, X., Chen, M., Chiang, C. W. K., Pulit, S., Horimoto, A., Krieger, J. E., Guindo-Martínez, M., Preuss, M., Schumann, C., Smit, R. A. J., Torres-Mejía, G., Acuña-Alonzo, V., Bedoya, G., Bortolini, M. C., Canizales-Quinteros, S., Gallo, C., González-José, R., Poletti, G., Rothhammer, F., Hakonarson, H., Igo, R., Adler, S. G., Iyengar, S. K., Nicholas, S. B., Gogarten, S. M., Isasi, C. R., Papnicolaou, G., Stilp, A. M., Qi, Q., Kho, M., Smith, J. A., Langefeld, C. D., Wagenknecht, L., Mckean-Cowdin, R., Gao, X. R., Nousome, D., Conti, D. V., Feng, Y., Allison, M. A., Arzumanyan, Z., Buchanan, T. A., Ida Chen, Y. D., Genter, P. M., Goodarzi, M. O., Hai, Y., Hsueh, W., Ipp, E., Kandeel, F. R., Lam, K., Li, X., Nadler, J. L., Raffel, L. J., Roll, K., Sandow, K., Tan, J., Taylor, K. D., Xiang, A. H., Yao, J., Audirac-Chalifour, A., de Jesus Peralta Romero, J., Hartwig, F., Horta, B., Blangero, J., Curran, J. E., Duggirala, R., Lehman, D. E., Puppala, S., Fejerman, L., John, E. M., Aguilar-Salinas, C., Burtt, N. P., Florez, J. C., García-Ortíz, H., González-Villalpando, C., Mercader, J., Orozco, L., Tusié-Luna, T., Blanco, E., Gahagan, S., Cox, N. J., Hanis, C., Butte, N. F., Cole, S. A., Comuzzie, A. G., Voruganti, V. S., Rohde, R., Wang, Y., Sofer, T., Ziv, E., Grant, S. F. A., Ruiz-Linares, A., Rotter, J. I., Haiman, C. A., Parra, E. J., Cruz, M., Loos, Ruth & North, K. E., 2022, In: Human Genetics and Genomics Advances. 3, 2, 21 p., 100099.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Clinical Characterization of Copy Number Variants Associated with Neurodevelopmental Disorders in a Large-scale Multiancestry Biobank

    Birnbaum, R., Mahjani, B., Loos, Ruth & Sharp, A. J., 2022, In: JAMA Psychiatry. 79, 3, p. 250-259

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., Wuttke, M., van der Most, P. J., Yang, Q., Ghasemi, S., Nutile, T., Li, Y., Pontali, G., Günther, F., Dehghan, A., Correa, A., Parsa, A., Feresin, A., de Vries, A. P. J., Zonderman, A. B., Smith, A. V., Oldehinkel, A. J., De Grandi, A., Rosenkranz, A. R., Franke, A., Teren, A., Metspalu, A., Hicks, A. A., Morris, A. P., Tönjes, A., Morgan, A., Podgornaia, A. I., Christensen, K., Lind, L., Kovacs, P., Rossing, Peter, Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Communications Biology . 5, p. 580 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

    Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J. M., Bidault, G., Vázquez-Borrego, M. C., Dias, A. R., Pucker, B., Dale, M., Campbell, M., Carobbio, S., Lin, Y. H., Vacca, M., Aron-Wisnewsky, J., Mora, S., Masiero, M. M., Emmanouilidou, A., Mukhopadhyay, S., Dougan, G., den Hoed, M., Loos, Ruth, Fernández-Real, J. M., Chiarugi, D., Clément, K. & Vidal-Puig, A., 2022, In: Nature Metabolism. 4, 4, p. 476-494 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F., Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jørgensen, Anja Moltke, Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Pacolet, A., Zhao, J., Balslev-Harder, M. N., Grarup, Niels, Linneberg, Allan René, Hansen, Torben, Melbye, Mads, Pedersen, Oluf Borbye, Pers, Tune H, Sørensen, Thorkild I.A., Zierath, Juleen R, Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

    Zhou, W., Kanai, M., Wu, K. H. H., Rasheed, H., Tsuo, K., Hirbo, J. B., Wang, Y., Bhattacharya, A., Zhao, H., Namba, S., Surakka, I., Wolford, B. N., Lo Faro, V., Lopera-Maya, E. A., Läll, K., Favé, M. J., Partanen, J. J., Chapman, S. B., Karjalainen, J., Kurki, M., Maasha, M., Brumpton, B. M., Chavan, S., Chen, T. T., Daya, M., Ding, Y., Feng, Y. C. A., Guare, L. A., Gignoux, C. R., Graham, S. E., Hornsby, W. E., Ingold, N., Ismail, S. I., Johnson, R., Laisk, T., Lin, K., Lv, J., Millwood, I. Y., Moreno-Grau, S., Nam, K., Palta, P., Pandit, A., Preuss, M. H., Saad, C., Setia-Verma, S., Thorsteinsdottir, U., Uzunovic, J., Verma, A., Zawistowski, M., Loos, Ruth, deCODE Genetics, D. G., Estonian Biobank, E. B., FinnGen, F., Generation Scotland, G. S., Genes & Health Research Team, G. &. H. R. T., LifeLines, L., Mass General Brigham Biobank, M. G. B. B., Michigan Genomics Initiative, M. G. I., National Biobank of Korea, N. B. O. K., Penn Medicine BioBank, P. M. B., Qatar Biobank, Q. B., The QSkin Sun and Health Study, T. Q. S. A. H. S., Taiwan Biobank, T. B., The HUNT Study, T. H. S., UCLA ATLAS Community Health Initiative, U. A. C. H. I., Uganda Genome Resource, U. G. R., UK Biobank, U. B., Biobank of the Americas, B. O. T. A., BioBank Japan Project, B. J. P., BioMe, B., BioVU, B., CanPath - Ontario Health Study, C. -. O. H. S., China Kadoorie Biobank Collaborative Group, C. K. B. C. G. & Colorado Center for Personalized Medicine, C. C. F. P. M., 2022, In: Cell Genomics. 2, 10, 20 p., 100192.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

    Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., Pampana, A., Gibson, C. J., Griffin, G. K., Clarke, S. L., Bhattacharya, R., Assimes, T. L., Emery, L. S., Stilp, A. M., Wong, Q., Broome, J., Laurie, C. A., Khan, A. T., Smith, A. V., Blackwell, T. W., Codd, V., Nelson, C. P., Yoneda, Z. T., Peralta, J. M., Bowden, D. W., Irvin, M. R., Boorgula, M., Zhao, W., Yanek, L. R., Wiggins, K. L., Hixson, J. E., Charles Gu, C., Peloso, G. M., Roden, D. M., Reupena, M. S., Hwu, C. M., DeMeo, D. L., North, K. E., Kelly, S., Musani, S. K., Bis, J. C., Lloyd-Jones, D. M., Johnsen, J. M., Preuss, M., Tracy, R. P., Loos, Ruth, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, T. S. O. L. A. G. A. S. (. G. & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, N. T. F. P. M. (. C., 2022, In: Science Advances. 8, 14, eabl6579.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B., Chiou, J., Miguel-Escalada, I., Della Briotta Parolo, P., Lin, K., Bragg, F., Preuss, M. H., Takeuchi, F., Nano, J., Guo, X., Lamri, A., Nakatochi, M., Scott, R. A., Lee, J., Huerta-Chagoya, A., Graff, M., Chai, J., Parra, E. J., Yao, J., Bielak, L. F., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, M. E., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Loos, Ruth, Hansen, Torben, Pedersen, Oluf Borbye & FinnGen, F., 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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