GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. / Sotelo-Hitschfeld, Tamara; Minère, Marielle; Klemm, Paul; Borgmann, Diba; Wnuk-Lipinski, Daria; Jais, Alexander; Jia, Xianglian; Corneliussen, Svenja; Kloppenburg, Peter; Fenselau, Henning; Brüning, Jens Claus.

In: Cell Reports, Vol. 43, No. 6, 114343, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sotelo-Hitschfeld, T, Minère, M, Klemm, P, Borgmann, D, Wnuk-Lipinski, D, Jais, A, Jia, X, Corneliussen, S, Kloppenburg, P, Fenselau, H & Brüning, JC 2024, 'GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia', Cell Reports, vol. 43, no. 6, 114343. https://doi.org/10.1016/j.celrep.2024.114343

APA

Sotelo-Hitschfeld, T., Minère, M., Klemm, P., Borgmann, D., Wnuk-Lipinski, D., Jais, A., Jia, X., Corneliussen, S., Kloppenburg, P., Fenselau, H., & Brüning, J. C. (2024). GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Reports, 43(6), [114343]. https://doi.org/10.1016/j.celrep.2024.114343

Vancouver

Sotelo-Hitschfeld T, Minère M, Klemm P, Borgmann D, Wnuk-Lipinski D, Jais A et al. GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Reports. 2024;43(6). 114343. https://doi.org/10.1016/j.celrep.2024.114343

Author

Sotelo-Hitschfeld, Tamara ; Minère, Marielle ; Klemm, Paul ; Borgmann, Diba ; Wnuk-Lipinski, Daria ; Jais, Alexander ; Jia, Xianglian ; Corneliussen, Svenja ; Kloppenburg, Peter ; Fenselau, Henning ; Brüning, Jens Claus. / GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. In: Cell Reports. 2024 ; Vol. 43, No. 6.

Bibtex

@article{b3c3645124824486bbd26383b480502a,
title = "GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia",
abstract = "Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin (POMC) neurons. Here, we validate the necessity of PNOCARC activity for HFD-induced inhibition of POMC neurons in mice and find that PNOCARC-neuron-dependent inhibition of POMC neurons is mediated by gamma-aminobutyric acid (GABA) release. When monitoring individual PNOCARC neuron activity via Ca2+ imaging, we find a subpopulation of PNOCARC neurons that is inhibited upon gastrointestinal calorie sensing and disinhibited upon HFD feeding. Combining retrograde rabies tracing and circuit mapping, we find that PNOC neurons from the bed nucleus of the stria terminalis (PNOCBNST) provide inhibitory input to PNOCARC neurons, and this inhibitory input is blunted upon HFD feeding. This work sheds light on how an increase in caloric content of the diet can rewire a neuronal circuit, paving the way to overconsumption and obesity development.",
keywords = "CP: Metabolism, CP: Neuroscience",
author = "Tamara Sotelo-Hitschfeld and Marielle Min{\`e}re and Paul Klemm and Diba Borgmann and Daria Wnuk-Lipinski and Alexander Jais and Xianglian Jia and Svenja Corneliussen and Peter Kloppenburg and Henning Fenselau and Br{\"u}ning, {Jens Claus}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2024",
doi = "10.1016/j.celrep.2024.114343",
language = "English",
volume = "43",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia

AU - Sotelo-Hitschfeld, Tamara

AU - Minère, Marielle

AU - Klemm, Paul

AU - Borgmann, Diba

AU - Wnuk-Lipinski, Daria

AU - Jais, Alexander

AU - Jia, Xianglian

AU - Corneliussen, Svenja

AU - Kloppenburg, Peter

AU - Fenselau, Henning

AU - Brüning, Jens Claus

N1 - Publisher Copyright: © 2024

PY - 2024

Y1 - 2024

N2 - Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin (POMC) neurons. Here, we validate the necessity of PNOCARC activity for HFD-induced inhibition of POMC neurons in mice and find that PNOCARC-neuron-dependent inhibition of POMC neurons is mediated by gamma-aminobutyric acid (GABA) release. When monitoring individual PNOCARC neuron activity via Ca2+ imaging, we find a subpopulation of PNOCARC neurons that is inhibited upon gastrointestinal calorie sensing and disinhibited upon HFD feeding. Combining retrograde rabies tracing and circuit mapping, we find that PNOC neurons from the bed nucleus of the stria terminalis (PNOCBNST) provide inhibitory input to PNOCARC neurons, and this inhibitory input is blunted upon HFD feeding. This work sheds light on how an increase in caloric content of the diet can rewire a neuronal circuit, paving the way to overconsumption and obesity development.

AB - Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin (POMC) neurons. Here, we validate the necessity of PNOCARC activity for HFD-induced inhibition of POMC neurons in mice and find that PNOCARC-neuron-dependent inhibition of POMC neurons is mediated by gamma-aminobutyric acid (GABA) release. When monitoring individual PNOCARC neuron activity via Ca2+ imaging, we find a subpopulation of PNOCARC neurons that is inhibited upon gastrointestinal calorie sensing and disinhibited upon HFD feeding. Combining retrograde rabies tracing and circuit mapping, we find that PNOC neurons from the bed nucleus of the stria terminalis (PNOCBNST) provide inhibitory input to PNOCARC neurons, and this inhibitory input is blunted upon HFD feeding. This work sheds light on how an increase in caloric content of the diet can rewire a neuronal circuit, paving the way to overconsumption and obesity development.

KW - CP: Metabolism

KW - CP: Neuroscience

U2 - 10.1016/j.celrep.2024.114343

DO - 10.1016/j.celrep.2024.114343

M3 - Journal article

C2 - 38865247

AN - SCOPUS:85195453308

VL - 43

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 6

M1 - 114343

ER -

ID: 395151804