Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Research output: Contribution to journal › Journal article › Research › peer-review

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Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. / Mills, Melinda C.; Tropf, Felix C.; Brazel, David M.; van Zuydam, Natalie; Vaez, Ahmad; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Andiappan, Anand Kumar; Arindrarto, Wibowo; Awadalla, Philip; Battle, Alexis; Beutner, Frank; Jan Bonder, Marc; Boomsma, Dorret I.; Christiansen, Mark W.; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; Frayling, Timothy; Gharib, Sina A.; Gibson, Greg; Heijmans, Bastiaan T.; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johannes; Kim, Yungil; Kirsten, Holger; Krohn, Knut; Kronberg, Jaanika; Kukushkina, Viktorija; Kutalik, Zoltan; Lee, Bernett; Lehtimäki, Terho; Loeffler, Markus; Marigorta, Urko M.; Mei, Hailang; Milani, Lili; Montgomery, Grant W.; Müller-Nurasyid, Martina; Nauck, Matthias; Nivard, Michel G.; Penninx, Brenda W. J. H.; Møllegaard, Stine; Pers, Tune H; eQTLGen Consortium; BIOS Consortium; Human Reproductive Behaviour Consortium.

In: Nature Human Behaviour, Vol. 5, 2021, p. 1717-1730.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mills, MC, Tropf, FC, Brazel, DM, van Zuydam, N, Vaez, A, Agbessi, M, Ahsan, H, Alves, I, Andiappan, AK, Arindrarto, W, Awadalla, P, Battle, A, Beutner, F, Jan Bonder, M, Boomsma, DI, Christiansen, MW, Claringbould, A, Deelen, P, Esko, T, Favé, M-J, Franke, L, Frayling, T, Gharib, SA, Gibson, G, Heijmans, BT, Hemani, G, Jansen, R, Kähönen, M, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Krohn, K, Kronberg, J, Kukushkina, V, Kutalik, Z, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, UM, Mei, H, Milani, L, Montgomery, GW, Müller-Nurasyid, M, Nauck, M, Nivard, MG, Penninx, BWJH, Møllegaard, S, Pers, TH, eQTLGen Consortium, BIOS Consortium & Human Reproductive Behaviour Consortium 2021, 'Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour', Nature Human Behaviour, vol. 5, pp. 1717-1730. https://doi.org/10.1038/s41562-021-01135-3

APA

Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., ... Human Reproductive Behaviour Consortium (2021). Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nature Human Behaviour, 5, 1717-1730. https://doi.org/10.1038/s41562-021-01135-3

Vancouver

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Agbessi M et al. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nature Human Behaviour. 2021;5:1717-1730. https://doi.org/10.1038/s41562-021-01135-3

Author

Mills, Melinda C. ; Tropf, Felix C. ; Brazel, David M. ; van Zuydam, Natalie ; Vaez, Ahmad ; Agbessi, Mawussé ; Ahsan, Habibul ; Alves, Isabel ; Andiappan, Anand Kumar ; Arindrarto, Wibowo ; Awadalla, Philip ; Battle, Alexis ; Beutner, Frank ; Jan Bonder, Marc ; Boomsma, Dorret I. ; Christiansen, Mark W. ; Claringbould, Annique ; Deelen, Patrick ; Esko, Tõnu ; Favé, Marie-Julie ; Franke, Lude ; Frayling, Timothy ; Gharib, Sina A. ; Gibson, Greg ; Heijmans, Bastiaan T. ; Hemani, Gibran ; Jansen, Rick ; Kähönen, Mika ; Kalnapenkis, Anette ; Kasela, Silva ; Kettunen, Johannes ; Kim, Yungil ; Kirsten, Holger ; Krohn, Knut ; Kronberg, Jaanika ; Kukushkina, Viktorija ; Kutalik, Zoltan ; Lee, Bernett ; Lehtimäki, Terho ; Loeffler, Markus ; Marigorta, Urko M. ; Mei, Hailang ; Milani, Lili ; Montgomery, Grant W. ; Müller-Nurasyid, Martina ; Nauck, Matthias ; Nivard, Michel G. ; Penninx, Brenda W. J. H. ; Møllegaard, Stine ; Pers, Tune H ; eQTLGen Consortium ; BIOS Consortium ; Human Reproductive Behaviour Consortium. / Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. In: Nature Human Behaviour. 2021 ; Vol. 5. pp. 1717-1730.

Bibtex

@article{b5ddf72ae7424f5a8c78d5474563b93d,
title = "Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour",
abstract = "Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.",
author = "Mills, {Melinda C.} and Tropf, {Felix C.} and Brazel, {David M.} and {van Zuydam}, Natalie and Ahmad Vaez and Mawuss{\'e} Agbessi and Habibul Ahsan and Isabel Alves and Andiappan, {Anand Kumar} and Wibowo Arindrarto and Philip Awadalla and Alexis Battle and Frank Beutner and {Jan Bonder}, Marc and Boomsma, {Dorret I.} and Christiansen, {Mark W.} and Annique Claringbould and Patrick Deelen and T{\~o}nu Esko and Marie-Julie Fav{\'e} and Lude Franke and Timothy Frayling and Gharib, {Sina A.} and Greg Gibson and Heijmans, {Bastiaan T.} and Gibran Hemani and Rick Jansen and Mika K{\"a}h{\"o}nen and Anette Kalnapenkis and Silva Kasela and Johannes Kettunen and Yungil Kim and Holger Kirsten and Knut Krohn and Jaanika Kronberg and Viktorija Kukushkina and Zoltan Kutalik and Bernett Lee and Terho Lehtim{\"a}ki and Markus Loeffler and Marigorta, {Urko M.} and Hailang Mei and Lili Milani and Montgomery, {Grant W.} and Martina M{\"u}ller-Nurasyid and Matthias Nauck and Nivard, {Michel G.} and Penninx, {Brenda W. J. H.} and Stine M{\o}llegaard and Pers, {Tune H} and {eQTLGen Consortium} and {BIOS Consortium} and {Human Reproductive Behaviour Consortium}",
year = "2021",
doi = "10.1038/s41562-021-01135-3",
language = "English",
volume = "5",
pages = "1717--1730",
journal = "Nature Human Behaviour",
issn = "2397-3374",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

AU - Mills, Melinda C.

AU - Tropf, Felix C.

AU - Brazel, David M.

AU - van Zuydam, Natalie

AU - Vaez, Ahmad

AU - Agbessi, Mawussé

AU - Ahsan, Habibul

AU - Alves, Isabel

AU - Andiappan, Anand Kumar

AU - Arindrarto, Wibowo

AU - Awadalla, Philip

AU - Battle, Alexis

AU - Beutner, Frank

AU - Jan Bonder, Marc

AU - Boomsma, Dorret I.

AU - Christiansen, Mark W.

AU - Claringbould, Annique

AU - Deelen, Patrick

AU - Esko, Tõnu

AU - Favé, Marie-Julie

AU - Franke, Lude

AU - Frayling, Timothy

AU - Gharib, Sina A.

AU - Gibson, Greg

AU - Heijmans, Bastiaan T.

AU - Hemani, Gibran

AU - Jansen, Rick

AU - Kähönen, Mika

AU - Kalnapenkis, Anette

AU - Kasela, Silva

AU - Kettunen, Johannes

AU - Kim, Yungil

AU - Kirsten, Holger

AU - Krohn, Knut

AU - Kronberg, Jaanika

AU - Kukushkina, Viktorija

AU - Kutalik, Zoltan

AU - Lee, Bernett

AU - Lehtimäki, Terho

AU - Loeffler, Markus

AU - Marigorta, Urko M.

AU - Mei, Hailang

AU - Milani, Lili

AU - Montgomery, Grant W.

AU - Müller-Nurasyid, Martina

AU - Nauck, Matthias

AU - Nivard, Michel G.

AU - Penninx, Brenda W. J. H.

AU - Møllegaard, Stine

AU - Pers, Tune H

AU - eQTLGen Consortium

AU - BIOS Consortium

AU - Human Reproductive Behaviour Consortium

PY - 2021

Y1 - 2021

N2 - Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.

AB - Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.

U2 - 10.1038/s41562-021-01135-3

DO - 10.1038/s41562-021-01135-3

M3 - Journal article

C2 - 34211149

VL - 5

SP - 1717

EP - 1730

JO - Nature Human Behaviour

JF - Nature Human Behaviour

SN - 2397-3374

ER -

ID: 273377635