PEN2: Metformin’s new partner at lysosome
Research output: Contribution to journal › Journal article › Research › peer-review
Metformin is the first-line therapy for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear. Ma and colleagues now identify a membrane protein PEN2 as a novel target of metformin at low concentrations which specifically activates lysosomal AMP-activated protein kinase (AMPK) via AMP-independent mechanism, leading to therapeutic benefits.
Original language | English |
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Journal | Cell Research |
Volume | 32 |
Pages (from-to) | 507-508 |
ISSN | 1001-0602 |
DOIs | |
Publication status | Published - 2022 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160082/pdf/41422_2022_Article_661.pdf
Final published version
ID: 307097381