Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice. / Biswas, Dipsikha; De Silva, A. B.K.H.; Mercer, Angella; Sarkar, Shreya; Kienesberger, Petra; Langille, Morgan; Rupasinghe, H. P.Vasantha; Pulinilkunnil, Thomas.

In: Journal of Functional Foods, Vol. 108, 105635, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Biswas, D, De Silva, ABKH, Mercer, A, Sarkar, S, Kienesberger, P, Langille, M, Rupasinghe, HPV & Pulinilkunnil, T 2023, 'Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice', Journal of Functional Foods, vol. 108, 105635. https://doi.org/10.1016/j.jff.2023.105635

APA

Biswas, D., De Silva, A. B. K. H., Mercer, A., Sarkar, S., Kienesberger, P., Langille, M., Rupasinghe, H. P. V., & Pulinilkunnil, T. (2023). Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice. Journal of Functional Foods, 108, [105635]. https://doi.org/10.1016/j.jff.2023.105635

Vancouver

Biswas D, De Silva ABKH, Mercer A, Sarkar S, Kienesberger P, Langille M et al. Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice. Journal of Functional Foods. 2023;108. 105635. https://doi.org/10.1016/j.jff.2023.105635

Author

Biswas, Dipsikha ; De Silva, A. B.K.H. ; Mercer, Angella ; Sarkar, Shreya ; Kienesberger, Petra ; Langille, Morgan ; Rupasinghe, H. P.Vasantha ; Pulinilkunnil, Thomas. / Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice. In: Journal of Functional Foods. 2023 ; Vol. 108.

Bibtex

@article{c024ec5dcae542c8bc08318c3c315294,
title = "Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice",
abstract = "Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis of obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or berry powder with low C3G (HFHS + BP). Mice fed HFHS + CE displayed short-term protection against weight gain, independent of food intake. HFHS + CE mice had lower hepatic diacylglycerols and triacylglycerols content and reduced expression of key lipogenic transcription factors. These metabolic changes also translated into improved glucose tolerance and insulin sensitivity. 16S rRNA sequencing revealed altered gut microbiota composition in the HFHS + CE group. In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications.",
keywords = "Anthocyanin, Cyanidin, Diabetes, Haskap, Obesity, Western diet",
author = "Dipsikha Biswas and {De Silva}, {A. B.K.H.} and Angella Mercer and Shreya Sarkar and Petra Kienesberger and Morgan Langille and Rupasinghe, {H. P.Vasantha} and Thomas Pulinilkunnil",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.jff.2023.105635",
language = "English",
volume = "108",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice

AU - Biswas, Dipsikha

AU - De Silva, A. B.K.H.

AU - Mercer, Angella

AU - Sarkar, Shreya

AU - Kienesberger, Petra

AU - Langille, Morgan

AU - Rupasinghe, H. P.Vasantha

AU - Pulinilkunnil, Thomas

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis of obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or berry powder with low C3G (HFHS + BP). Mice fed HFHS + CE displayed short-term protection against weight gain, independent of food intake. HFHS + CE mice had lower hepatic diacylglycerols and triacylglycerols content and reduced expression of key lipogenic transcription factors. These metabolic changes also translated into improved glucose tolerance and insulin sensitivity. 16S rRNA sequencing revealed altered gut microbiota composition in the HFHS + CE group. In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications.

AB - Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis of obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or berry powder with low C3G (HFHS + BP). Mice fed HFHS + CE displayed short-term protection against weight gain, independent of food intake. HFHS + CE mice had lower hepatic diacylglycerols and triacylglycerols content and reduced expression of key lipogenic transcription factors. These metabolic changes also translated into improved glucose tolerance and insulin sensitivity. 16S rRNA sequencing revealed altered gut microbiota composition in the HFHS + CE group. In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications.

KW - Anthocyanin

KW - Cyanidin

KW - Diabetes

KW - Haskap

KW - Obesity

KW - Western diet

U2 - 10.1016/j.jff.2023.105635

DO - 10.1016/j.jff.2023.105635

M3 - Journal article

AN - SCOPUS:85168481563

VL - 108

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

M1 - 105635

ER -

ID: 369923505