Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

Research output: Contribution to journal › Journal article › Research › peer-review

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Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots. / Palani, Nagendra P.; Horvath, Carla; Timshel, Pascal N.; Folkertsma, Pytrik; Grønning, Alexander G.B.; Henriksen, Tora I.; Peijs, Lone; Jensen, Verena H.; Sun, Wenfei; Jespersen, Naja Z.; Wolfrum, Christian; Pers, Tune H.; Nielsen, Søren; Scheele, Camilla.

In: Nature Metabolism, Vol. 5, No. 6, 2023, p. 996-1013.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Palani, NP, Horvath, C, Timshel, PN, Folkertsma, P, Grønning, AGB, Henriksen, TI, Peijs, L, Jensen, VH, Sun, W, Jespersen, NZ, Wolfrum, C, Pers, TH, Nielsen, S & Scheele, C 2023, 'Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots', Nature Metabolism, vol. 5, no. 6, pp. 996-1013. https://doi.org/10.1038/s42255-023-00820-z

APA

Palani, N. P., Horvath, C., Timshel, P. N., Folkertsma, P., Grønning, A. G. B., Henriksen, T. I., Peijs, L., Jensen, V. H., Sun, W., Jespersen, N. Z., Wolfrum, C., Pers, T. H., Nielsen, S., & Scheele, C. (2023). Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots. Nature Metabolism, 5(6), 996-1013. https://doi.org/10.1038/s42255-023-00820-z

Vancouver

Palani NP, Horvath C, Timshel PN, Folkertsma P, Grønning AGB, Henriksen TI et al. Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots. Nature Metabolism. 2023;5(6):996-1013. https://doi.org/10.1038/s42255-023-00820-z

Author

Palani, Nagendra P. ; Horvath, Carla ; Timshel, Pascal N. ; Folkertsma, Pytrik ; Grønning, Alexander G.B. ; Henriksen, Tora I. ; Peijs, Lone ; Jensen, Verena H. ; Sun, Wenfei ; Jespersen, Naja Z. ; Wolfrum, Christian ; Pers, Tune H. ; Nielsen, Søren ; Scheele, Camilla. / Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots. In: Nature Metabolism. 2023 ; Vol. 5, No. 6. pp. 996-1013.

Bibtex

@article{9ecec88dbd894e399bac7bd1c1419cac,
title = "Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots",
abstract = "Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipogenic cells, dependent on media. Label transfer algorithms recapitulate the cell types in human adipose tissue datasets. In conclusion, we provide a differentiation map of human adipocytes and define the multipotent SWAT cell, providing a new perspective on adipose tissue regulation.",
author = "Palani, {Nagendra P.} and Carla Horvath and Timshel, {Pascal N.} and Pytrik Folkertsma and Gr{\o}nning, {Alexander G.B.} and Henriksen, {Tora I.} and Lone Peijs and Jensen, {Verena H.} and Wenfei Sun and Jespersen, {Naja Z.} and Christian Wolfrum and Pers, {Tune H.} and S{\o}ren Nielsen and Camilla Scheele",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s42255-023-00820-z",
language = "English",
volume = "5",
pages = "996--1013",
journal = "Nature Metabolism",
issn = "2522-5812",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

AU - Palani, Nagendra P.

AU - Horvath, Carla

AU - Timshel, Pascal N.

AU - Folkertsma, Pytrik

AU - Grønning, Alexander G.B.

AU - Henriksen, Tora I.

AU - Peijs, Lone

AU - Jensen, Verena H.

AU - Sun, Wenfei

AU - Jespersen, Naja Z.

AU - Wolfrum, Christian

AU - Pers, Tune H.

AU - Nielsen, Søren

AU - Scheele, Camilla

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipogenic cells, dependent on media. Label transfer algorithms recapitulate the cell types in human adipose tissue datasets. In conclusion, we provide a differentiation map of human adipocytes and define the multipotent SWAT cell, providing a new perspective on adipose tissue regulation.

AB - Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipogenic cells, dependent on media. Label transfer algorithms recapitulate the cell types in human adipose tissue datasets. In conclusion, we provide a differentiation map of human adipocytes and define the multipotent SWAT cell, providing a new perspective on adipose tissue regulation.

U2 - 10.1038/s42255-023-00820-z

DO - 10.1038/s42255-023-00820-z

M3 - Journal article

C2 - 37337126

AN - SCOPUS:85161976894

VL - 5

SP - 996

EP - 1013

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

IS - 6

ER -

ID: 361390242