Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

Research output: Contribution to journal › Review › Research › peer-review

Standard

Challenges in tackling energy expenditure as obesity therapy : From preclinical models to clinical application. / Löffler, Mona C.; Betz, Matthias J.; Blondin, Denis P.; Augustin, Robert; Sharma, Anand K.; Tseng, Yu Hua; Scheele, Camilla; Zimdahl, Heike; Mark, Michael; Hennige, Anita M.; Wolfrum, Christian; Langhans, Wolfgang; Hamilton, Bradford S.; Neubauer, Heike.

In: Molecular Metabolism, Vol. 51, 101237, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Löffler, MC, Betz, MJ, Blondin, DP, Augustin, R, Sharma, AK, Tseng, YH, Scheele, C, Zimdahl, H, Mark, M, Hennige, AM, Wolfrum, C, Langhans, W, Hamilton, BS & Neubauer, H 2021, 'Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application', Molecular Metabolism, vol. 51, 101237. https://doi.org/10.1016/j.molmet.2021.101237

APA

Löffler, M. C., Betz, M. J., Blondin, D. P., Augustin, R., Sharma, A. K., Tseng, Y. H., Scheele, C., Zimdahl, H., Mark, M., Hennige, A. M., Wolfrum, C., Langhans, W., Hamilton, B. S., & Neubauer, H. (2021). Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application. Molecular Metabolism, 51, [101237]. https://doi.org/10.1016/j.molmet.2021.101237

Vancouver

Löffler MC, Betz MJ, Blondin DP, Augustin R, Sharma AK, Tseng YH et al. Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application. Molecular Metabolism. 2021;51. 101237. https://doi.org/10.1016/j.molmet.2021.101237

Author

Löffler, Mona C. ; Betz, Matthias J. ; Blondin, Denis P. ; Augustin, Robert ; Sharma, Anand K. ; Tseng, Yu Hua ; Scheele, Camilla ; Zimdahl, Heike ; Mark, Michael ; Hennige, Anita M. ; Wolfrum, Christian ; Langhans, Wolfgang ; Hamilton, Bradford S. ; Neubauer, Heike. / Challenges in tackling energy expenditure as obesity therapy : From preclinical models to clinical application. In: Molecular Metabolism. 2021 ; Vol. 51.

Bibtex

@article{25d5388e7e3e4a8499cc8db84eba4040,
title = "Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application",
abstract = "Background: A chronic imbalance of energy intake and energy expenditure results in excess fat storage. The obesity often caused by this overweight is detrimental to the health of millions of people. Understanding both sides of the energy balance equation and their counter-regulatory mechanisms is critical to the development of effective therapies to treat this epidemic. Scope of review: Behaviors surrounding ingestion have been reviewed extensively. This review focuses more specifically on energy expenditure regarding bodyweight control, with a particular emphasis on the organs and attractive metabolic processes known to reduce bodyweight. Moreover, previous and current attempts at anti-obesity strategies focusing on energy expenditure are highlighted. Precise measurements of energy expenditure, which consist of cellular, animal, and human models, as well as measurements of their translatability, are required to provide the most effective therapies. Major conclusions: A precise understanding of the components surrounding energy expenditure, including tailored approaches based on genetic, biomarker, or physical characteristics, must be integrated into future anti-obesity treatments. Further comprehensive investigations are required to define suitable treatments, especially because the complex nature of the human perspective remains poorly understood.",
keywords = "Clinical translatability, Energy expenditure, Energy homeostasis, Methodology, Obesity",
author = "L{\"o}ffler, {Mona C.} and Betz, {Matthias J.} and Blondin, {Denis P.} and Robert Augustin and Sharma, {Anand K.} and Tseng, {Yu Hua} and Camilla Scheele and Heike Zimdahl and Michael Mark and Hennige, {Anita M.} and Christian Wolfrum and Wolfgang Langhans and Hamilton, {Bradford S.} and Heike Neubauer",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
doi = "10.1016/j.molmet.2021.101237",
language = "English",
volume = "51",
journal = "Molecular Metabolism",
issn = "2212-8778",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Challenges in tackling energy expenditure as obesity therapy

T2 - From preclinical models to clinical application

AU - Löffler, Mona C.

AU - Betz, Matthias J.

AU - Blondin, Denis P.

AU - Augustin, Robert

AU - Sharma, Anand K.

AU - Tseng, Yu Hua

AU - Scheele, Camilla

AU - Zimdahl, Heike

AU - Mark, Michael

AU - Hennige, Anita M.

AU - Wolfrum, Christian

AU - Langhans, Wolfgang

AU - Hamilton, Bradford S.

AU - Neubauer, Heike

N1 - Publisher Copyright: © 2021 The Author(s)

PY - 2021

Y1 - 2021

N2 - Background: A chronic imbalance of energy intake and energy expenditure results in excess fat storage. The obesity often caused by this overweight is detrimental to the health of millions of people. Understanding both sides of the energy balance equation and their counter-regulatory mechanisms is critical to the development of effective therapies to treat this epidemic. Scope of review: Behaviors surrounding ingestion have been reviewed extensively. This review focuses more specifically on energy expenditure regarding bodyweight control, with a particular emphasis on the organs and attractive metabolic processes known to reduce bodyweight. Moreover, previous and current attempts at anti-obesity strategies focusing on energy expenditure are highlighted. Precise measurements of energy expenditure, which consist of cellular, animal, and human models, as well as measurements of their translatability, are required to provide the most effective therapies. Major conclusions: A precise understanding of the components surrounding energy expenditure, including tailored approaches based on genetic, biomarker, or physical characteristics, must be integrated into future anti-obesity treatments. Further comprehensive investigations are required to define suitable treatments, especially because the complex nature of the human perspective remains poorly understood.

AB - Background: A chronic imbalance of energy intake and energy expenditure results in excess fat storage. The obesity often caused by this overweight is detrimental to the health of millions of people. Understanding both sides of the energy balance equation and their counter-regulatory mechanisms is critical to the development of effective therapies to treat this epidemic. Scope of review: Behaviors surrounding ingestion have been reviewed extensively. This review focuses more specifically on energy expenditure regarding bodyweight control, with a particular emphasis on the organs and attractive metabolic processes known to reduce bodyweight. Moreover, previous and current attempts at anti-obesity strategies focusing on energy expenditure are highlighted. Precise measurements of energy expenditure, which consist of cellular, animal, and human models, as well as measurements of their translatability, are required to provide the most effective therapies. Major conclusions: A precise understanding of the components surrounding energy expenditure, including tailored approaches based on genetic, biomarker, or physical characteristics, must be integrated into future anti-obesity treatments. Further comprehensive investigations are required to define suitable treatments, especially because the complex nature of the human perspective remains poorly understood.

KW - Clinical translatability

KW - Energy expenditure

KW - Energy homeostasis

KW - Methodology

KW - Obesity

U2 - 10.1016/j.molmet.2021.101237

DO - 10.1016/j.molmet.2021.101237

M3 - Review

C2 - 33878401

AN - SCOPUS:85105304710

VL - 51

JO - Molecular Metabolism

JF - Molecular Metabolism

SN - 2212-8778

M1 - 101237

ER -

ID: 278486664